apoptosis books

Related books on 'apoptosis'

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Apoptosis: Physiology and Pathology

by: Douglas R. Green
publisher: Cambridge University Press, published: 2011-08-22
ASIN: 0521886562
EAN: 9780521886567
sales rank: 418051
Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This pathological dysregulation of cell death can be characterized by either too much loss of essential cells in the heart, brain, and other tissues with little regenerative capacity or by too little cell turnover in self-renewing tissues, giving rise to cancer and other maladies. This is a process of fundamental importance for development and normal health, which is altered in many disease conditions. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.

Neuronal Cell Apoptosis

publisher: Nova Science Publishers Inc (, published: 2011-07
ASIN: 1613246331
EAN: 9781613246337
Neuronal apoptosis is a normal physiological process that is an essential and integral part of neurogenesis. The massive overproduction of neurons that occur during the development of the brain is followed by a programmed cell death of roughly one-half of the originally formed neurons. In this book, the authors present topical research in the study of neuronal cell apoptosis, including comparative microarray analysis of multiple neurodegenerative models; death of neuronal and glial cells induced by photodynamic treatment; cell death during cerebellar development and the fundamental mechanisms; and, pathophysiological implications of neuronal apoptosis.

Means to and End: Apoptosis and Other Cell Death Mechanisms

by: Douglas R. Green
publisher: Cold Spring Harbor, published: 2010-10-29
ASIN: 0879698888
EAN: 9780879698881
sales rank: 972651
Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

publisher: Wiley-VCH, published: 2006-04-18
ASIN: 3527312374
EAN: 9783527312375
sales rank: 2387376
Here, an international and highly distinguished team of authors leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.

Viruses and Apoptosis (Progress in Molecular and Subcellular Biology)

publisher: Springer, published: 2008-03-27
ASIN: 3540742638
EAN: 9783540742630
sales rank: 3404228
Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.

Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

publisher: Humana Press, published: 2007-12-17
ASIN: 1588295273
EAN: 9781588295279
sales rank: 1581335
This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in cancer

publisher: Springer, published: 2010-12-16
ASIN: 9048181666
EAN: 9789048181667
sales rank: 2754501
The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.

When Cells Die: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death

publisher: Wiley-Liss, published: 1998-03-30
ASIN: 0471165697
EAN: 9780471165699
sales rank: 2004385
When Cells Die

A Comprehensive Evaluation of Apoptosis and Programmed Cell Death

Edited by Richard A. Lockshin, Zahra Zakeri, and Jonathan L. Tilly

Cell death is fast becoming one of the most dynamic areas of biological research -involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods -making it difficult for scientists to get an overview of the field.

When Cells Die establishes a coherent framework for the study of cell death -cutting across viewpoints and disciplines and consolidating disparate research efforts. Leading international researchers describe a wide range of topics, including evaluation methods for programmed cell death and apoptosis in numerous tissues and circumstances; genetic mechanism, signal transduction, and observed manifestations of physiological cell death; model systems ranging from nematodes to humans; relevant work in cancer research, AIDS, immune disorders, fertility, eye disease, and Alzheimer's disease; and more.

Written to provide an in-depth overview of cell death, the book is divided into five major parts:
* The phenomenon of cell death
* Themes and approaches to cell death
* Cell death where mitosis is high and evanescence is desirable
* Cell death in long-lived cells
* The clinical relevance of apoptosis.

When Cells Die offers a comprehensive introduction to an intriguing discipline, insight into areas in need of exploration, and information on new techniques and therapeutic applications -all supported with diagrams and flowcharts and a fully cross-referenced and indexed text. It is important reading for anyone working in cell and developmental biology, neuroscience, immunology, cancer research, and virology. It is also useful for advanced undergraduate and graduate-level students, postdoctoral fellows, and researchers just entering the field.

Apoptosis, Genomic Integrity and Cancer

by: Julien L. Van Lancker
publisher: Jones & Bartlett Publishers, published: 2005-12-12
ASIN: 0763745413
EAN: 9780763745417
sales rank: 1438190
Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell’s replication and apoptosis. This balance depends largely, although not exclusively, on the integrity of the genome. Cancer is a flagrant illustration of the danger of imbalance between cell proliferation and cell death. As cells replicate unfettered by normal controls, they invade the surrounding healthy population of cells, and they colonize distant organs. Van Lancker’s book introduces readers to the molecules involved in apoptosis and genomic integrity and considers the gain or loss of the functions that lead to cancer. This excellent educational resource is designed for scientists and academics in the medical sciences, graduate and undergraduate education in cell biology, biochemistry, physiology, pharmacology, public health, toxicology, experimental pathology, and radiation biology.

Essentials of Apoptosis: A Guide for Basic and Clinical Research

publisher: Humana Press, published: 2009-06-04
ASIN: 1603273808
EAN: 9781603273800
sales rank: 2200060
This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly – chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.

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	Apoptosis: Physiology and Pathology by: Douglas R. Green publisher: Cambridge University Press, published: 2011-08-22 ASIN: 0521886562 EAN: 9780521886567 sales rank: 418051 Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This pathological dysregulation of cell death can be characterized by either too much loss of essential cells in the heart, brain, and other tissues with little regenerative capacity or by too little cell turnover in self-renewing tissues, giving rise to cancer and other maladies. This is a process of fundamental importance for development and normal health, which is altered in many disease conditions. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
	Neuronal Cell Apoptosis publisher: Nova Science Publishers Inc (, published: 2011-07 ASIN: 1613246331 EAN: 9781613246337 Neuronal apoptosis is a normal physiological process that is an essential and integral part of neurogenesis. The massive overproduction of neurons that occur during the development of the brain is followed by a programmed cell death of roughly one-half of the originally formed neurons. In this book, the authors present topical research in the study of neuronal cell apoptosis, including comparative microarray analysis of multiple neurodegenerative models; death of neuronal and glial cells induced by photodynamic treatment; cell death during cerebellar development and the fundamental mechanisms; and, pathophysiological implications of neuronal apoptosis.
	Means to and End: Apoptosis and Other Cell Death Mechanisms by: Douglas R. Green publisher: Cold Spring Harbor, published: 2010-10-29 ASIN: 0879698888 EAN: 9780879698881 sales rank: 972651 Apoptosis (programmed cell death) plays a critical role in development, normal physiology, and many diseases, including cancer. Apoptosis researchers form a distinct research community but investigators in many areas of cell, developmental, and molecular biology, as well as immunology and neurobiology, also study the process. This short book describes our detailed understanding of the mechanisms involved in apoptotic signaling and execution, covering signal transducers, caspases, BCL-2family proteins, mitochondrial molecules, and IAPs. It also critically discusses key questions that remain in the field, for example, whether caspases are always necessary, the distinction between the intrinsic and extrinsic pathways of apoptosis, and the role of mitochondria, that are often glossed over or ignored elsewhere.
	Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts publisher: Wiley-VCH, published: 2006-04-18 ASIN: 3527312374 EAN: 9783527312375 sales rank: 2387376 Here, an international and highly distinguished team of authors leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.
	Viruses and Apoptosis (Progress in Molecular and Subcellular Biology) publisher: Springer, published: 2008-03-27 ASIN: 3540742638 EAN: 9783540742630 sales rank: 3404228 Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.
	Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development) publisher: Humana Press, published: 2007-12-17 ASIN: 1588295273 EAN: 9781588295279 sales rank: 1581335 This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.
	Apoptosis in Carcinogenesis and Chemotherapy: Apoptosis in cancer publisher: Springer, published: 2010-12-16 ASIN: 9048181666 EAN: 9789048181667 sales rank: 2754501 The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.
	When Cells Die: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death publisher: Wiley-Liss, published: 1998-03-30 ASIN: 0471165697 EAN: 9780471165699 sales rank: 2004385 When Cells Die A Comprehensive Evaluation of Apoptosis and Programmed Cell Death Edited by Richard A. Lockshin, Zahra Zakeri, and Jonathan L. Tilly Cell death is fast becoming one of the most dynamic areas of biological research -involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods -making it difficult for scientists to get an overview of the field. When Cells Die establishes a coherent framework for the study of cell death -cutting across viewpoints and disciplines and consolidating disparate research efforts. Leading international researchers describe a wide range of topics, including evaluation methods for programmed cell death and apoptosis in numerous tissues and circumstances; genetic mechanism, signal transduction, and observed manifestations of physiological cell death; model systems ranging from nematodes to humans; relevant work in cancer research, AIDS, immune disorders, fertility, eye disease, and Alzheimer's disease; and more. Written to provide an in-depth overview of cell death, the book is divided into five major parts: * The phenomenon of cell death * Themes and approaches to cell death * Cell death where mitosis is high and evanescence is desirable * Cell death in long-lived cells * The clinical relevance of apoptosis. When Cells Die offers a comprehensive introduction to an intriguing discipline, insight into areas in need of exploration, and information on new techniques and therapeutic applications -all supported with diagrams and flowcharts and a fully cross-referenced and indexed text. It is important reading for anyone working in cell and developmental biology, neuroscience, immunology, cancer research, and virology. It is also useful for advanced undergraduate and graduate-level students, postdoctoral fellows, and researchers just entering the field.
	Apoptosis, Genomic Integrity and Cancer by: Julien L. Van Lancker publisher: Jones & Bartlett Publishers, published: 2005-12-12 ASIN: 0763745413 EAN: 9780763745417 sales rank: 1438190 Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell’s replication and apoptosis. This balance depends largely, although not exclusively, on the integrity of the genome. Cancer is a flagrant illustration of the danger of imbalance between cell proliferation and cell death. As cells replicate unfettered by normal controls, they invade the surrounding healthy population of cells, and they colonize distant organs. Van Lancker’s book introduces readers to the molecules involved in apoptosis and genomic integrity and considers the gain or loss of the functions that lead to cancer. This excellent educational resource is designed for scientists and academics in the medical sciences, graduate and undergraduate education in cell biology, biochemistry, physiology, pharmacology, public health, toxicology, experimental pathology, and radiation biology.
	Essentials of Apoptosis: A Guide for Basic and Clinical Research publisher: Humana Press, published: 2009-06-04 ASIN: 1603273808 EAN: 9781603273800 sales rank: 2200060 This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly – chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.