c-elegans books

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In the Beginning Was the Worm: Finding the Secrets of Life in a Tiny Hermaphrodite

by: Andrew Brown
publisher: Columbia University Press, published: 2003-07-15
ASIN: 0231131461
EAN: 9780231131469
sales rank: 614718

This is the story of how three men won the Nobel Prize for their research on the humble nematode worm C. elegans; how their extraordinary discovery led to the sequencing of the human genome; how a global multibillion-dollar industry was born; and how the mysteries of life were revealed in a tiny, brainless worm.
In 1998 the nematode worm -- perhaps the most intensively studied animal on earth -- was the first multicellular organism ever to have its genome sequenced and its DNA mapped and read. "When we understand the worm, we will understand life," predicted John Sulston, one of the three Nobel laureates, and his prediction proved astonishingly accurate. Four years later, the research that led to this extraordinary event garnered three scientists a Nobel Prize. Along with Robert Horvitz and Sydney Brenner, Sulston discovered the phenomenon of programmed cell death in the worm, an essential concept that explains how biological development occurs in animal life and, as Horvitz later showed, how it occurs in human life. C. elegans is about as simple as an animal can be, but understanding its genetic organization is helping to reveal the mechanisms of life and, by extension, the mechanisms of our own lives. In the Beginning Was the Worm shows that in order to unlock the secrets of the human genome we must first understand the worm.
But this story is about more than just the worm. It is about how an eccentric group of impassioned scientists toiled in near anonymity for years, driven only by a deep passion for knowledge and scientific discovery. It is the story of countless hours of research, immense ambition, and one of the greatest discoveries in human history.

C. elegans: Methods and Applications (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-12-01
ASIN: 161737668X
EAN: 9781617376689
sales rank: 1911272
Nonmammalian model organisms have become a cornerstone of systems biology research. Like the Rosetta Stone, which enabled modern scholars to decode ancient Egyptian hieroglyphics, model organisms enable biologists to decipher the genetic code underlying the complex physiological processes common to all life. C. elegans provides a particularly striking example of the experimental utility of model organisms. Genetic, molecular and systems biological characterization of this organism is greatly facilitated by its short life cycle and high rate reproduction, and by the ease with which it can be cultured in the laboratory. C. elegans also has a fully sequenced and well-annotated genome, which is assembled in readily accessible public databases along with virtually all other biological data on this organism. C. elegans: Methods and Applications aims to enhance the readily available methodologies for the study of C. elegans by providing overviews and concise, step-by-step descriptions of the most state-of-the-art methods currently being utilized in the field. Some of the methods presented include forward and reverse genetic analysis, data mining and comparative genomics strategies, electron and fluorescence microscopy methods, automated imaging methods for worm behavioral analysis, functional genomics strategies, and cutting-edge methods for physiological analyses. This comprehensive collection of methods, written by experts in the field, endeavors to serve as a roadmap for researchers, illustrating the type or research that is possible with C. elegans, and illuminating its potential as a vehicle for future discovery.

C. elegans Atlas

by: David H. Hall
publisher: Cold Spring Harbor Laboratory Press, published: 2008-01-01
ASIN: 0879697946
EAN: 9780879697945
sales rank: 2288364
Derived from the acclaimed online ''WormAtlas,''C. elegans Atlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as ''the worm'' by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegans II monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology. Related Titles from the Publisher: The Nematode Caenorhabditis elegans C. elegans II

The Nematode Caenorhabditis Elegans (The Cold Spring Harbor Monograph Series)

by: William B. Wood
publisher: Cold Spring Harbor Laboratory Press, published: 1988-06-01
ASIN: 0879694335
EAN: 9780879694333
sales rank: 392631
In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. Since then, with the help of a growing number of investigators, knowledge about the biology of;the worm; has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete;wiring diagram; of cell contacts in the animal. Recent years have also brought the first successes in molecularly cloning genes of developmental interest defined only by mutation, using transposon tagging as a generally applicable method for identification of the desired DNA sequences. Reintroduction of cloned DNA sequences into the genome has recently been accomplished. A physical map of the genome has been assembled with a combination of cosmid and YAC genes. This;Book of the Worm; serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists

C. elegans: A Practical Approach

publisher: Oxford University Press, USA, published: 1999-12-15
ASIN: 0199637385
EAN: 9780199637386
sales rank: 1386275
Caenorhabditis Elegans has been a popular model organism for biological research for over thirty years and has been used to investigate many aspects of animal development, for example apoptosis, the Hox genes, signal transduction pathways, and the development of the nervous system. It has recently taken on new importance with the publication of the entire genome sequence in 1998. The first chapter gives all the basic information on C. elegans required to use it: it's natural history, anatomy, life cycle, development, and evolution. Information on how to obtain, grow, and maintain C. elegans for use as a model system is given in Chapter 4. Chapters 2 and 3 describe the genome project and show how to use genome sequence information by searching the database for homologues using different search methods and then how to analyse the search data. The next chapter gives the essential practical details of transformation and common uses for the technique. Chapter 6 covers reverse genetics and describes strategies for gene inactivation that are known to work in C elegans: epigenetic inactivation and mutational germ line inactivation. Chapter 7 is designed to help the user analyse phenotype by microscopy and includes Normaski, fluorescence, 4-dimensional, and electron microscopy. Techniques for studying the neurobiology of C. elegans are given in chapter 8. Chapter 9 describes the three commonly used approaches for studying gene expression and Chapter 10 deals with the common methods of molecular biology essential for gene characterization. C. elegans is not the ideal organism for biochemical studies, but chapter 11 describes several procedures for producing biochemically useful quantities of pure tissues. The final chapter is about conventional genetics and details the standard procedures for selfing and crossing; mutagenesis and mutant screening; characterization of mutants; gene mapping; temperature-shift experiments and mosaic analysis. Caenorhabditis Elegans: A Practical Approach will therefore provide all the background information necessary for use of C. elegans as a model system.

Animal Behavior

by: Michael D. Breed
publisher: Academic Press, published: 2011-02-18
ASIN: 012372581X
EAN: 9780123725813
sales rank: 92537

This textbook covers the broad sweep of animal behavior from its neurological underpinnings to the importance of behavior in conservation. The authors, Michael Breed and Janice Moore, bring almost 60 years of combined experience as university professors to this textbook, much of that teaching animal behavior. An entire chapter is devoted to the vibrant new field of behavior and conservation, including topics such as social behavior and the relationship between parasites, pathogens and behavior. Thoughtful coverage has also been given to foraging behavior, mating and parenting behavior, anti-predator behavior and learning.

This text addresses the physiological foundations of behavior in a way that is both accessible and inviting. Each chapter begins with learning objectives and concludes with thought-provoking questions. Additionally, special terms and definitions are highlighted throughout. Animal Behavior provides a rich resource for students (and professors) from a wide range of life science disciplines.

Provides a solid background in the neurophysiological and endocrinological bases of animal behavior as well as exceptionally strong coverage of social behavior

Includes behavior and homeostatic mechanisms, behavior and conservation, and behavioral aspects of disease

Highlights aspects of behavior that relate to domestic animals in particular

Lab manual with fully developed and tested laboratory exercises available for courses that have labs (http://www.elsevierdirect.com/product.jsp?isbn=9780123725820)

Companion site for faculty and students to enhance their learning experience at: www.elsevierdirect.com/companions/9780123725813

Principles of Neural Science

by: Eric Kandel
publisher: McGraw-Hill Medical, published: 2000-01-05
ASIN: 0838577016
EAN: 9780838577011
sales rank: 10574

A Doody's Core Title for 2011!

5 STAR DOODY'S REVIEW!
"This is a simply wonderful book that makes accessible in one place all the details of how the neuron and brain work. The writing is clear. The drawings are elegant and educational. The book is a feast for both the eye and mind. The richness, the beauty, and the complexity of neuroscience is all captured in this superb book."--Doody's Review Service
Now in resplendent color, the new edition continues to define the latest in the scientific understanding of the brain, the nervous system, and human behavior. Each chapter is thoroughly revised and includes the impact of molecular biology in the mechanisms underlying developmental processes and in the pathogenesis of disease. Important features to this edition include a new chapter - Genes and Behavior; a complete updating of development of the nervous system; the genetic basis of neurological and psychiatric disease; cognitive neuroscience of perception, planning, action, motivation and memory; ion channel mechanisms; and much more. (20011101)

The Neurobiology of C. elegans, Volume 69 (International Review of Neurobiology)

publisher: Academic Press, published: 2006-02-07
ASIN: 0123668700
EAN: 9780123668707
sales rank: 2801986
The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.

RNA Interference in Practice: Principles, Basics, and Methods for Gene Silencing in C.elegans, Drosophila, and Mammals

by: Ute Schepers
publisher: Wiley-VCH, published: 2005-01-31
ASIN: 3527310207
EAN: 9783527310203
sales rank: 2826294
This hands-on guide to RNA interference brings the power of targeted gene silencing to any laboratory with the basic equipment for handling nucleic acids. In easy-to-follow, step-by-step protocols you will learn:
How RNAi works in worms, flies and mammals
How to design the most efficient RNAi constructs
How to achieve transient, stable and conditional RNAi in cell cultures
How to determine the efficiency of an RNAi experiment
and how to use RNAi for gene therapy
All the protocols have been thoroughly tested in the author's own laboratory, and she provides examples of successful experiments and troubleshooting hints to help in establishing your own successful RNAi experiments. Also includes a list of suppliers for RNAi reagents and equipment as well as a glossary of terms.

Native American Food Plants: An Ethnobotanical Dictionary

by: Daniel Moerman E.
publisher: Timber Press, published: 2010-10-27
ASIN: 1604691891
EAN: 9781604691894
sales rank: 169141
Based on 25 years of research that combed every historical and anthropological record of Native American ways, this unprecedented culinary dictionary documents the food uses of 1500 plants by 220 Native American tribes from early times to the present.

Like anthropologist Daniel E. Moerman’s previous volume, Native American Medicinal Plants, this extensive compilation draws on the same research as his monumental Native American Ethnobotany, this time culling 32 categories of food uses from an extraordinary range of species. Hundreds of plants, both native and introduced, are described. The usage categories include beverages, breads, fruits, spices, desserts, snacks, dried foods, and condiments, as well as curdling agents, dietary aids, preservatives, and even foods specifically for emergencies. Each example of tribal use includes a brief description of how the food was prepared. In addition, multiple indexes are arranged by tribe, type of food, and common names to make it easy to pursue specific research.

An essential reference for anthropologists, ethnobotanists, and food scientists, this will also make fascinating reading for anyone interested in the history of wild and cultivated local foods and the remarkable practical botanical knowledge of Native American forbears.

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	In the Beginning Was the Worm: Finding the Secrets of Life in a Tiny Hermaphrodite by: Andrew Brown publisher: Columbia University Press, published: 2003-07-15 ASIN: 0231131461 EAN: 9780231131469 sales rank: 614718 This is the story of how three men won the Nobel Prize for their research on the humble nematode worm C. elegans; how their extraordinary discovery led to the sequencing of the human genome; how a global multibillion-dollar industry was born; and how the mysteries of life were revealed in a tiny, brainless worm. In 1998 the nematode worm -- perhaps the most intensively studied animal on earth -- was the first multicellular organism ever to have its genome sequenced and its DNA mapped and read. "When we understand the worm, we will understand life," predicted John Sulston, one of the three Nobel laureates, and his prediction proved astonishingly accurate. Four years later, the research that led to this extraordinary event garnered three scientists a Nobel Prize. Along with Robert Horvitz and Sydney Brenner, Sulston discovered the phenomenon of programmed cell death in the worm, an essential concept that explains how biological development occurs in animal life and, as Horvitz later showed, how it occurs in human life. C. elegans is about as simple as an animal can be, but understanding its genetic organization is helping to reveal the mechanisms of life and, by extension, the mechanisms of our own lives. In the Beginning Was the Worm shows that in order to unlock the secrets of the human genome we must first understand the worm. But this story is about more than just the worm. It is about how an eccentric group of impassioned scientists toiled in near anonymity for years, driven only by a deep passion for knowledge and scientific discovery. It is the story of countless hours of research, immense ambition, and one of the greatest discoveries in human history.
	C. elegans: Methods and Applications (Methods in Molecular Biology) publisher: Humana Press, published: 2010-12-01 ASIN: 161737668X EAN: 9781617376689 sales rank: 1911272 Nonmammalian model organisms have become a cornerstone of systems biology research. Like the Rosetta Stone, which enabled modern scholars to decode ancient Egyptian hieroglyphics, model organisms enable biologists to decipher the genetic code underlying the complex physiological processes common to all life. C. elegans provides a particularly striking example of the experimental utility of model organisms. Genetic, molecular and systems biological characterization of this organism is greatly facilitated by its short life cycle and high rate reproduction, and by the ease with which it can be cultured in the laboratory. C. elegans also has a fully sequenced and well-annotated genome, which is assembled in readily accessible public databases along with virtually all other biological data on this organism. C. elegans: Methods and Applications aims to enhance the readily available methodologies for the study of C. elegans by providing overviews and concise, step-by-step descriptions of the most state-of-the-art methods currently being utilized in the field. Some of the methods presented include forward and reverse genetic analysis, data mining and comparative genomics strategies, electron and fluorescence microscopy methods, automated imaging methods for worm behavioral analysis, functional genomics strategies, and cutting-edge methods for physiological analyses. This comprehensive collection of methods, written by experts in the field, endeavors to serve as a roadmap for researchers, illustrating the type or research that is possible with C. elegans, and illuminating its potential as a vehicle for future discovery.
	C. elegans Atlas by: David H. Hall publisher: Cold Spring Harbor Laboratory Press, published: 2008-01-01 ASIN: 0879697946 EAN: 9780879697945 sales rank: 2288364 Derived from the acclaimed online ''WormAtlas,''C. elegans Atlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as ''the worm'' by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegans II monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology. Related Titles from the Publisher: The Nematode Caenorhabditis elegans C. elegans II
	The Nematode Caenorhabditis Elegans (The Cold Spring Harbor Monograph Series) by: William B. Wood publisher: Cold Spring Harbor Laboratory Press, published: 1988-06-01 ASIN: 0879694335 EAN: 9780879694333 sales rank: 392631 In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. Since then, with the help of a growing number of investigators, knowledge about the biology of;the worm; has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete;wiring diagram; of cell contacts in the animal. Recent years have also brought the first successes in molecularly cloning genes of developmental interest defined only by mutation, using transposon tagging as a generally applicable method for identification of the desired DNA sequences. Reintroduction of cloned DNA sequences into the genome has recently been accomplished. A physical map of the genome has been assembled with a combination of cosmid and YAC genes. This;Book of the Worm; serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists
	C. elegans: A Practical Approach publisher: Oxford University Press, USA, published: 1999-12-15 ASIN: 0199637385 EAN: 9780199637386 sales rank: 1386275 Caenorhabditis Elegans has been a popular model organism for biological research for over thirty years and has been used to investigate many aspects of animal development, for example apoptosis, the Hox genes, signal transduction pathways, and the development of the nervous system. It has recently taken on new importance with the publication of the entire genome sequence in 1998. The first chapter gives all the basic information on C. elegans required to use it: it's natural history, anatomy, life cycle, development, and evolution. Information on how to obtain, grow, and maintain C. elegans for use as a model system is given in Chapter 4. Chapters 2 and 3 describe the genome project and show how to use genome sequence information by searching the database for homologues using different search methods and then how to analyse the search data. The next chapter gives the essential practical details of transformation and common uses for the technique. Chapter 6 covers reverse genetics and describes strategies for gene inactivation that are known to work in C elegans: epigenetic inactivation and mutational germ line inactivation. Chapter 7 is designed to help the user analyse phenotype by microscopy and includes Normaski, fluorescence, 4-dimensional, and electron microscopy. Techniques for studying the neurobiology of C. elegans are given in chapter 8. Chapter 9 describes the three commonly used approaches for studying gene expression and Chapter 10 deals with the common methods of molecular biology essential for gene characterization. C. elegans is not the ideal organism for biochemical studies, but chapter 11 describes several procedures for producing biochemically useful quantities of pure tissues. The final chapter is about conventional genetics and details the standard procedures for selfing and crossing; mutagenesis and mutant screening; characterization of mutants; gene mapping; temperature-shift experiments and mosaic analysis. Caenorhabditis Elegans: A Practical Approach will therefore provide all the background information necessary for use of C. elegans as a model system.
	Animal Behavior by: Michael D. Breed publisher: Academic Press, published: 2011-02-18 ASIN: 012372581X EAN: 9780123725813 sales rank: 92537 This textbook covers the broad sweep of animal behavior from its neurological underpinnings to the importance of behavior in conservation. The authors, Michael Breed and Janice Moore, bring almost 60 years of combined experience as university professors to this textbook, much of that teaching animal behavior. An entire chapter is devoted to the vibrant new field of behavior and conservation, including topics such as social behavior and the relationship between parasites, pathogens and behavior. Thoughtful coverage has also been given to foraging behavior, mating and parenting behavior, anti-predator behavior and learning. This text addresses the physiological foundations of behavior in a way that is both accessible and inviting. Each chapter begins with learning objectives and concludes with thought-provoking questions. Additionally, special terms and definitions are highlighted throughout. Animal Behavior provides a rich resource for students (and professors) from a wide range of life science disciplines. Provides a solid background in the neurophysiological and endocrinological bases of animal behavior as well as exceptionally strong coverage of social behavior Includes behavior and homeostatic mechanisms, behavior and conservation, and behavioral aspects of disease Highlights aspects of behavior that relate to domestic animals in particular Lab manual with fully developed and tested laboratory exercises available for courses that have labs (http://www.elsevierdirect.com/product.jsp?isbn=9780123725820) Companion site for faculty and students to enhance their learning experience at: www.elsevierdirect.com/companions/9780123725813
	Principles of Neural Science by: Eric Kandel publisher: McGraw-Hill Medical, published: 2000-01-05 ASIN: 0838577016 EAN: 9780838577011 sales rank: 10574 A Doody's Core Title for 2011! 5 STAR DOODY'S REVIEW! "This is a simply wonderful book that makes accessible in one place all the details of how the neuron and brain work. The writing is clear. The drawings are elegant and educational. The book is a feast for both the eye and mind. The richness, the beauty, and the complexity of neuroscience is all captured in this superb book."--Doody's Review Service Now in resplendent color, the new edition continues to define the latest in the scientific understanding of the brain, the nervous system, and human behavior. Each chapter is thoroughly revised and includes the impact of molecular biology in the mechanisms underlying developmental processes and in the pathogenesis of disease. Important features to this edition include a new chapter - Genes and Behavior; a complete updating of development of the nervous system; the genetic basis of neurological and psychiatric disease; cognitive neuroscience of perception, planning, action, motivation and memory; ion channel mechanisms; and much more. (20011101)
	The Neurobiology of C. elegans, Volume 69 (International Review of Neurobiology) publisher: Academic Press, published: 2006-02-07 ASIN: 0123668700 EAN: 9780123668707 sales rank: 2801986 The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.
	RNA Interference in Practice: Principles, Basics, and Methods for Gene Silencing in C.elegans, Drosophila, and Mammals by: Ute Schepers publisher: Wiley-VCH, published: 2005-01-31 ASIN: 3527310207 EAN: 9783527310203 sales rank: 2826294 This hands-on guide to RNA interference brings the power of targeted gene silencing to any laboratory with the basic equipment for handling nucleic acids. In easy-to-follow, step-by-step protocols you will learn: How RNAi works in worms, flies and mammals How to design the most efficient RNAi constructs How to achieve transient, stable and conditional RNAi in cell cultures How to determine the efficiency of an RNAi experiment and how to use RNAi for gene therapy All the protocols have been thoroughly tested in the author's own laboratory, and she provides examples of successful experiments and troubleshooting hints to help in establishing your own successful RNAi experiments. Also includes a list of suppliers for RNAi reagents and equipment as well as a glossary of terms.
	Native American Food Plants: An Ethnobotanical Dictionary by: Daniel Moerman E. publisher: Timber Press, published: 2010-10-27 ASIN: 1604691891 EAN: 9781604691894 sales rank: 169141 Based on 25 years of research that combed every historical and anthropological record of Native American ways, this unprecedented culinary dictionary documents the food uses of 1500 plants by 220 Native American tribes from early times to the present. Like anthropologist Daniel E. Moerman’s previous volume, Native American Medicinal Plants, this extensive compilation draws on the same research as his monumental Native American Ethnobotany, this time culling 32 categories of food uses from an extraordinary range of species. Hundreds of plants, both native and introduced, are described. The usage categories include beverages, breads, fruits, spices, desserts, snacks, dried foods, and condiments, as well as curdling agents, dietary aids, preservatives, and even foods specifically for emergencies. Each example of tribal use includes a brief description of how the food was prepared. In addition, multiple indexes are arranged by tribe, type of food, and common names to make it easy to pursue specific research. An essential reference for anthropologists, ethnobotanists, and food scientists, this will also make fascinating reading for anyone interested in the history of wild and cultivated local foods and the remarkable practical botanical knowledge of Native American forbears.