Life science and biomedical books

Related books on 'dna-methylation'

	Nutrition in Epigenetics publisher: Wiley-Blackwell, published: 2011-06-28 ASIN: 081381605X EAN: 9780813816050 sales rank: 696653 The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.
	DNA Methylation Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2002-03-01 ASIN: 0896036189 EAN: 9780896036185 sales rank: 2111917 DNA Methylation Protocols offer a set of readily reproducible protocols of the analysis of DNA methylation and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of abnormal DNA methylation and the isolation and measurement of demethylases and related proteins.
	From Genes to Genomes: Concepts and Applications of DNA Technology by: Jeremy W. Dale publisher: Wiley, published: 2012-02-14 ASIN: 0470683856 EAN: 9780470683859 sales rank: 105869 The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.
	Understanding DNA, Third Edition: The Molecule and How it Works by: Chris R. Calladine publisher: Academic Press, published: 2004-04-13 ASIN: 0121550893 EAN: 9780121550899 sales rank: 1525075 The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth. The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA. * Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix * Outlines the methods used to study DNA structure * Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension
	Minding My Mitochondria 2nd Edition: How I overcame secondary progressive multiple sclerosis (MS) and got out of my wheelchair. by: Terry L. Wahls publisher: TZ Press, published: 2010-04-01 ASIN: 0982175086 EAN: 9780982175088 sales rank: 2436 Dr. Terry Wahls links micronutrient starvation to the epidemics of chronic disease that are overtaking modern society. She explains the key roles mitochondria play in maintaining a healthy brain and body. Americans are eating so poorly, something we all know to be true, that the majority of Americans are missing key building blocks that are needed for brain cells to be healthy. The result is an epidemic of depression, aggression, multiple sclerosis and early dementia. She then teaches you how to eat for healthy mitochondria, a healthy brain and a healthy body in language that is clear and concise, even for those without a science background. In this book, Dr. Wahls explains basic brain biology in simple terms. She tells us what vitamin, mineral and essential fat building blocks are needed by the mitochondria and other key structures in the brain. Then she explains what foods are good sources for those key nutrients. Over a hundred recipes are provided to help get you started on this new way of eating. A portion of the proceeds from the sale of this book will be used to fund research into the benefits of these interventions in others.
	DNA Methylation: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2008-12-02 ASIN: 1934115614 EAN: 9781934115619 sales rank: 2310148 Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.
	DNA Methylation: Basic Mechanisms (Current Topics in Microbiology and Immunology) publisher: Springer, published: 2010-11-19 ASIN: 3642067085 EAN: 9783642067082 The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and function of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.
	DNA Methylation in Plants (Nova Biomedical) by: Boris F. Vanyushin publisher: Nova Science Pub Inc, published: 2008-10 ASIN: 1606920510 EAN: 9781606920510 sales rank: 3106699 A high degree of nuclear DNA (nDNA) methylation is a specific feature of plant genomes, they do contain 5-methylcytosine (m5C) and N6-methyl adenine (m6A). More than 30 per cent m5C is located in CNG sequences. Specific changes in DNA methylation accompany the entire life of a plant starting from seed germination up to the death programmed or induced by various agents and factors of biological or abiotic nature. Modulation of DNA methylation is one of the possible modes of the hormonal action in plant. DNA methylation in plants is species-, tissue-, organelle- and age-specific; it is involved in the control of all genetic functions including transcription, replication, DNA repair, gene transposition and cell differentiation.DNA methylation is engaged in gene silencing and parental imprinting, it controls trans genes and foreign DNA.Plants have much more complicated and sophisticated system of the multi-component and sometimes even conjugated genome (nuclear DNA) methylations compared with animals; besides, unlike animals, they have the plastids with their own unique DNA modification system that may control plastid differentiation and functioning; DNA methylation in plant mitochondria is performed in other fashion compared with it in nuclei. The nuclear DNA methylation system is controlled by three major families of cytosine DNA-methyltransferase genes, at least.In contrast to animals the inactivation of major maintenance methyltransferase MET1 (similar to animal Dnmt1) has no significant consequences for plant survival. Other plant cytosine DNA-methyltransferases have no analogs in animals. Some of them (DRM) are responsible for de novo DNA methylation including asymmetric sequences. Plant gene may be methylated at both adenine and cytosine residues; specific adenine DNA-methyltransferase was described. Adenine DNA methylation may influence cytosine modification and vice versa.Anyway, two different systems of the genome modification based on methylation of adenines and cytosines coexist in higher plants. The specific endonucleases discriminating between methylated and unmethylated DNA are present in plants. Thus, plants may have restriction-modification system. There are peculiar complicated controls for growth and development by DNA methylations in plants; they are well co-ordinated with other epigenetic signals modulating chromatin organisation.
	DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment) publisher: Springer, published: 2011-01-11 ASIN: 9048169178 EAN: 9789048169177 sales rank: 3315765 This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.
	DNA Methylation Microarrays: Experimental Design and Statistical Analysis (Chapman & Hall/CRC Biostatistics Series) by: Sun-Chong Wang publisher: Chapman and Hall/CRC, published: 2008-04-24 ASIN: 1420067273 EAN: 9781420067279 sales rank: 2420698 Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same underlying principles as gene expression microarrays, many of the analyses in the text also apply to microarray-based gene expression and histone modification (ChIP-on-chip) studies. After introducing basic statistics, the book describes wet-bench technologies that produce the data for analysis and explains how to preprocess the data to remove systematic artifacts resulting from measurement imperfections. It then explores differential methylation and genomic tiling arrays. Focusing on exploratory data analysis, the next several chapters show how cluster and network analyses can link the functions and roles of unannotated DNA elements with known ones. The book concludes by surveying the open source software (R and Bioconductor), public databases, and other online resources available for microarray research. Requiring only limited knowledge of statistics and programming, this book helps readers gain a solid understanding of the methodological foundations of DNA microarray analysis.

Page: 1 2 > 596