gene-delivery-or-gene-transfer books

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Gene Transfer: Delivery and Expression of DNA And RNA, A Laboratory Manual

by: Theodore Friedmann
publisher: Cold Spring Harbor Laboratory Press, published: 2006-12-01
ASIN: 0879697652
EAN: 9780879697655
sales rank: 2285995
Understanding GENE FUNCTION and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer; Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring appropriate expression. The detailed, step by step protocols cover a variety of methods, both well established and newly evolving. These includeviral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. Each chaper includes technical discussions for selectionof the appropriate system and strategies for delivery. Related Titles from the Publisher Binding and Kinetics for Molecular Biologists; DNA Replication and Human Disease; DNA Science; Epigenetics; Genes and Signals; Genetic Variation; Genomes; Molecular Biology of the Gene, 6th Edition; Recombinant DNA: Genes and Genomes - A Short Course

Gene Delivery to Mammalian Cells: Nonviral Gene Transfer Techniques (Methods in Molecular Biology) (Methods in Molecular Biology)

publisher: Humana Press, published: 2003-10-28
ASIN: 1588290867
EAN: 9781588290861
sales rank: 1574793
Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics. An accompanying volume, Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors.

Non-viral Gene Therapy: Gene Design and Delivery

publisher: Springer, published: 2005-09-26
ASIN: 4431251227
EAN: 9784431251224
sales rank: 2391749

The development of gene medicine based on the concept of molecular therapy has opened new medical horizons. Among the many techniques in gene medicine, gene design and delivery are especially significant in clinical applications. This book presents state-of-the-art information on non-viral gene-delivery techniques, covering a broad spectrum of disciplines that include chemistry, molecular biology, cell biology, and pharmacokinetics. Major sections introduce molecules for gene delivery and their properties; technologies of controlled gene delivery in vitro and in vivo; therapeutic genes and the status of clinical applications; and the design of genes based on current RNA technology, with revolutionary developments in the world of RNAi shown to be key factors in gene medicine. This groundbreaking work is an invaluable resource for researchers and engineers in genetic engineering, molecular medicine, biochemical engineering, and biotechnology.

Gene Transfer and the Ethics of First-in-Human Research: Lost in Translation

by: Jonathan Kimmelman
publisher: Cambridge University Press, published: 2009-12-07
ASIN: 0521690846
EAN: 9780521690843
sales rank: 2183677
Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions.

Gene Transfer to Animal Cells (Advanced Methods)

by: Richard Twyman
publisher: Taylor & Francis, published: 2005-02-11
ASIN: 1859962041
EAN: 9781859962046
sales rank: 1861935

Gene transfer to animal cells was first achieved more than thirty years ago. Since then, transformation technology has developed rapidly, resulting in a multitude of techniques for cell transformation and the creation of transgenic animals. As with any expanding technology, it becomes difficult to keep track of all the developments and to find a concise and comprehensive source of information that explains all the underlying principles.

Gene Transfer to Animals Cells addresses this problem by describing the principles behind gene transfer technologies, how gene expression is controlled in animal cells and how advanced strategies can be used to add, exchange or delete sequences from animal genomes in a conditional manner. A final chapter provides an overview of all the applications of animal cell transformation in farming, medicine and research.

Immunology of Gene Therapy

by: Roland W. Herzog
publisher: Wiley-Blackwell, published: 2008-12-03
ASIN: 0470134062
EAN: 9780470134061
sales rank: 3033948

Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic
Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases
Broad appeal - applicable for immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research

Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine

publisher: Springer, published: 2005-12-21
ASIN: 1852339799
EAN: 9781852339791
sales rank: 1562923

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Vector Targeting for Therapeutic Gene Delivery

by: David T. Curiel
publisher: Wiley-Liss, published: 2002-08-26
ASIN: 0471434795
EAN: 9780471434795
sales rank: 3891985
"...very informative and comprehensive...belongs on the shelf ofevery library and lab providing essential resources for research onvector design or delivery."
-Cancer Biology and Therapy
This comprehensive volume presents the most recent advances in target definitiontechnology and provides a detailed overview on the rational design of targetedvectors for gene therapy. A theoretical framework for advanced vector design is provided that integrates all of the allied sciences relevant to the study of vector targeting. The text discusses the basic underlying science and then leads to discussions of the various viral vectors and methods of definingtargets. Finally, an expert outlook on promising therapeutic applications is offered.

Protocols for Neural Cell Culture (Springer Protocols Handbooks)

publisher: Humana Press, published: 2009-10-29
ASIN: 1607612917
EAN: 9781607612919
sales rank: 694185
Since the conception of this acclaimed series of volumes examining neural tissue culture, the expansion of neuroscience has continued to produce vital discoveries that utilize tissue culture methodologies. The expert contributors to the fourth edition of Protocols for Neural Cell Culture refine existing protocols and present the emerging new techniques and culture media formulations linked with the many advances in neuroscience. While highlighting updated experimental procedures for many of the classical neural tissue culture preps, the volume addresses topics such as regenerative medicine and the methods to grow and expand embryonic and adult neural stem cells. Essential techniques for the isolation, expansion, and cryopreservation of neural tissue from mouse, rat, and human sources are covered, as well as methods to assess aspects of cell function (calcium imaging) and cell death. With its detailed, step-by-step laboratory protocols, this volume provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Protocols for Neural Cell Culture, Fourth Edition continues the previous editions’ tradition of exceptional quality and thorough coverage in tissue culture protocols for today’s neuroscience in order to inspire researchers in the field to further explore this imperative area of study.

Liposomes in Gene Delivery

by: Danilo D. Lasic
publisher: CRC-Press, published: 1997-06-30
ASIN: 0849331099
EAN: 9780849331091
sales rank: 3502336
From Liposomes in Gene Delivery molecular biologists will gain a basic knowledge of lipids, liposomes, and other gene delivery vehicles; lipid and drug delivery scientists will better understand DNA, molecular biology, and DNA manipulation. Topics include an introduction to nucleic acids, a theoretical description of DNA, recombinant technology, lipids and liposomes, stability and interaction properties of lipids and liposomes, complexation of lipids and liposomes with DNA plasmids, gene expression of genosomes in various models, structure

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	Gene Transfer: Delivery and Expression of DNA And RNA, A Laboratory Manual by: Theodore Friedmann publisher: Cold Spring Harbor Laboratory Press, published: 2006-12-01 ASIN: 0879697652 EAN: 9780879697655 sales rank: 2285995 Understanding GENE FUNCTION and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer; Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring appropriate expression. The detailed, step by step protocols cover a variety of methods, both well established and newly evolving. These includeviral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. Each chaper includes technical discussions for selectionof the appropriate system and strategies for delivery. Related Titles from the Publisher Binding and Kinetics for Molecular Biologists; DNA Replication and Human Disease; DNA Science; Epigenetics; Genes and Signals; Genetic Variation; Genomes; Molecular Biology of the Gene, 6th Edition; Recombinant DNA: Genes and Genomes - A Short Course
	Gene Delivery to Mammalian Cells: Nonviral Gene Transfer Techniques (Methods in Molecular Biology) (Methods in Molecular Biology) publisher: Humana Press, published: 2003-10-28 ASIN: 1588290867 EAN: 9781588290861 sales rank: 1574793 Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics. An accompanying volume, Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors.
	Non-viral Gene Therapy: Gene Design and Delivery publisher: Springer, published: 2005-09-26 ASIN: 4431251227 EAN: 9784431251224 sales rank: 2391749 The development of gene medicine based on the concept of molecular therapy has opened new medical horizons. Among the many techniques in gene medicine, gene design and delivery are especially significant in clinical applications. This book presents state-of-the-art information on non-viral gene-delivery techniques, covering a broad spectrum of disciplines that include chemistry, molecular biology, cell biology, and pharmacokinetics. Major sections introduce molecules for gene delivery and their properties; technologies of controlled gene delivery in vitro and in vivo; therapeutic genes and the status of clinical applications; and the design of genes based on current RNA technology, with revolutionary developments in the world of RNAi shown to be key factors in gene medicine. This groundbreaking work is an invaluable resource for researchers and engineers in genetic engineering, molecular medicine, biochemical engineering, and biotechnology.
	Gene Transfer and the Ethics of First-in-Human Research: Lost in Translation by: Jonathan Kimmelman publisher: Cambridge University Press, published: 2009-12-07 ASIN: 0521690846 EAN: 9780521690843 sales rank: 2183677 Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions.
	Gene Transfer to Animal Cells (Advanced Methods) by: Richard Twyman publisher: Taylor & Francis, published: 2005-02-11 ASIN: 1859962041 EAN: 9781859962046 sales rank: 1861935 Gene transfer to animal cells was first achieved more than thirty years ago. Since then, transformation technology has developed rapidly, resulting in a multitude of techniques for cell transformation and the creation of transgenic animals. As with any expanding technology, it becomes difficult to keep track of all the developments and to find a concise and comprehensive source of information that explains all the underlying principles. Gene Transfer to Animals Cells addresses this problem by describing the principles behind gene transfer technologies, how gene expression is controlled in animal cells and how advanced strategies can be used to add, exchange or delete sequences from animal genomes in a conditional manner. A final chapter provides an overview of all the applications of animal cell transformation in farming, medicine and research.
	Immunology of Gene Therapy by: Roland W. Herzog publisher: Wiley-Blackwell, published: 2008-12-03 ASIN: 0470134062 EAN: 9780470134061 sales rank: 3033948 Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases Broad appeal - applicable for immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research
	Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine publisher: Springer, published: 2005-12-21 ASIN: 1852339799 EAN: 9781852339791 sales rank: 1562923 Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.
	Vector Targeting for Therapeutic Gene Delivery by: David T. Curiel publisher: Wiley-Liss, published: 2002-08-26 ASIN: 0471434795 EAN: 9780471434795 sales rank: 3891985 "...very informative and comprehensive...belongs on the shelf ofevery library and lab providing essential resources for research onvector design or delivery." -Cancer Biology and Therapy This comprehensive volume presents the most recent advances in target definitiontechnology and provides a detailed overview on the rational design of targetedvectors for gene therapy. A theoretical framework for advanced vector design is provided that integrates all of the allied sciences relevant to the study of vector targeting. The text discusses the basic underlying science and then leads to discussions of the various viral vectors and methods of definingtargets. Finally, an expert outlook on promising therapeutic applications is offered.
	Protocols for Neural Cell Culture (Springer Protocols Handbooks) publisher: Humana Press, published: 2009-10-29 ASIN: 1607612917 EAN: 9781607612919 sales rank: 694185 Since the conception of this acclaimed series of volumes examining neural tissue culture, the expansion of neuroscience has continued to produce vital discoveries that utilize tissue culture methodologies. The expert contributors to the fourth edition of Protocols for Neural Cell Culture refine existing protocols and present the emerging new techniques and culture media formulations linked with the many advances in neuroscience. While highlighting updated experimental procedures for many of the classical neural tissue culture preps, the volume addresses topics such as regenerative medicine and the methods to grow and expand embryonic and adult neural stem cells. Essential techniques for the isolation, expansion, and cryopreservation of neural tissue from mouse, rat, and human sources are covered, as well as methods to assess aspects of cell function (calcium imaging) and cell death. With its detailed, step-by-step laboratory protocols, this volume provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Protocols for Neural Cell Culture, Fourth Edition continues the previous editions’ tradition of exceptional quality and thorough coverage in tissue culture protocols for today’s neuroscience in order to inspire researchers in the field to further explore this imperative area of study.
	Liposomes in Gene Delivery by: Danilo D. Lasic publisher: CRC-Press, published: 1997-06-30 ASIN: 0849331099 EAN: 9780849331091 sales rank: 3502336 From Liposomes in Gene Delivery molecular biologists will gain a basic knowledge of lipids, liposomes, and other gene delivery vehicles; lipid and drug delivery scientists will better understand DNA, molecular biology, and DNA manipulation. Topics include an introduction to nucleic acids, a theoretical description of DNA, recombinant technology, lipids and liposomes, stability and interaction properties of lipids and liposomes, complexation of lipids and liposomes with DNA plasmids, gene expression of genosomes in various models, structure