Life science and biomedical books

Related books on 'gene-targeting knockout-gene'

	Cytokine Knockouts (Contemporary Immunology) publisher: Humana Press, published: 1998-01-15 ASIN: 0896033686 EAN: 9780896033689 sales rank: 4596066 This book is a unique compendium of the latest information on cytokine knockouts. Each chapter-written by the leading scientists who created or studied each knockout-illuminates the physiological consequences of deficiency in a particular cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed.
	Transgenic Models in Pharmacology (Handbook of Experimental Pharmacology) publisher: Springer Verlag, published: 2003-10-10 ASIN: 3540001093 EAN: 9783540001096 sales rank: 8455033 Up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.
	From Genes to Genomes: Concepts and Applications of DNA Technology by: Jeremy W. Dale publisher: Wiley, published: 2012-02-14 ASIN: 0470683856 EAN: 9780470683859 sales rank: 143354 The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.
	The Perfect Gene Diet: Use Your Body's Own APO E Gene to Treat High Cholesterol, Weight Problems, Heart Disease, Alzheimer's...and More! by: Pamela McDonald NP publisher: Hay House, published: 2010-10-10 ASIN: 140192848X EAN: 9781401928483 sales rank: 8142 This comprehensive work by nurse practitioner Pamela McDonald reveals the latest breakthrough in health and nutrition focusing on the APO E gene, which affects cholesterol levels, heart and Alzheimer’s disease, and much more. It is widely known that each genotype requires its own balance of carbohydrates, fats, and proteins for optimal health. Within these pages, Pamela presents the latest information so that you can make appropriate diet and exercise choices relevant to your particular APO E genotype. The result will be an ideal level of health and well-being, which will reduce your likelihood of developing so many of the debilitating diseases that are prevalent in our society today. As Pamela says, “You have a choice for your health . . . backpack or bedpan?”
	Failure Is Not an Option: Mission Control From Mercury to Apollo 13 and Beyond by: Gene Kranz publisher: Simon & Schuster, published: 2009-06-23 ASIN: 1439148813 EAN: 9781439148815 sales rank: 33837 Gene Kranz was present at the creation of America's manned space program and was a key player in it for three decades. As a flight director in NASA's Mission Control, Kranz witnessed firsthand the making of history. He participated in the space program from the early days of the Mercury program to the last Apollo mission, and beyond. He endured the disastrous first years when rockets blew up and the United States seemed to fall further behind the Soviet Union in the space race. He helped to launch Alan Shepard and John Glenn, then assumed the flight director's role in the Gemini program, which he guided to fruition. With his teammates, he accepted the challenge to carry out President John F. Kennedy's commitment to land a man on the Moon before the end of the 1960s. Kranz was flight director for both Apollo 11, the mission in which Neil Armstrong fulfilled President Kennedy's pledge, and Apollo 13. He headed the Tiger Team that had to figure out how to bring the three Apollo 13 astronauts safely back to Earth. (In the film Apollo 13, Kranz was played by the actor Ed Harris, who earned an Academy Award nomination for his performance.) In Failure Is Not an Option, Gene Kranz recounts these thrilling historic events and offers new information about the famous flights. What appeared as nearly flawless missions to the Moon were, in fact, a series of hair-raising near misses. When the space technology failed, as it sometimes did, the controllers' only recourse was to rely on their skills and those of their teammates. Kranz takes us inside Mission Control and introduces us to some of the whiz kids -- still in their twenties, only a few years out of college -- who had to figure it all out as they went along, creating a great and daring enterprise. He reveals behind-the-scenes details to demonstrate the leadership, discipline, trust, and teamwork that made the space program a success. Finally, Kranz reflects on what has happened to the space program and offers his own bold suggestions about what we ought to be doing in space now. This is a fascinating firsthand account written by a veteran mission controller of one of America's greatest achievements.
	Gene Knockout Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2009-03-27 ASIN: 1934115266 EAN: 9781934115268 sales rank: 360209 With the completion of the mouse and human genome sequences, the functional characterization of every mammalian gene and the deciphering of their molecular interaction network has become the next major challenge, and the mouse genome provides a convenient and vital model for these studies. In "Gene Knockout Protocols, Second Edition", distinguished contributors with extensive experience in the gene targeting and mouse genetics fields reveal a comprehensive collection of step-by-step laboratory protocols. Emphasizing the many new mutagenesis techniques developed over the last seven years, the volume covers topics such as gene modification in ES cells, stem cell manipulation, the generation of genetically engineered mice, and mutant phenotype analysis. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain brief introductions to their respective subjects, lists of the necessary materials and reagents, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Fully updated and authoritative, "Gene Knockout Protocols, Second Edition" provides a unique collection of expert bench protocols certain to be a valuable resource for those just entering the field of gene targeting but also for all genetic researchers today.
	Lewin's Essential GENES by: Benjamin Lewin publisher: Jones & Bartlett Publishers, published: 2009-03-02 ASIN: 0763759155 EAN: 9780763759155 sales rank: 231347 The new edition of Lewin's Essential GENES is the most accessible, student-friendly text of its kind! Completely revised and rewritten, the Second Edition continues to provide students with the latest findings in the field of molecular biology and molecular genetics. An exceptional new pedagogy enhances student learning and helps readers understand and retain key material like never before. New Concept and Reasoning Checks at the end of each chapter section, End of Chapter Questions and Further Readings for each chapter, and several categories of special topics boxes within each chapter expand and reinforce important concepts. The reorganization of topics in this edition allows students to focus more sharply on the key material at hand and improves the natural flow of course material. New end-of-chapter questions reviews major points in the chapter and allow students to test themselves on important course material.
	The ABCs of Gene Cloning by: Dominic Wong publisher: Springer, published: 2005-12-09 ASIN: 0387286632 EAN: 9780387286631 sales rank: 455065 Clear and concise, this easy-to-use text offers an introductory course on the language of gene cloning, covering microbial, plant, and animal systems. The essential concepts in biology relevant to the understanding of gene cloning are presented in a well-organized and accessible manner. This updated version of the first edition is an invaluable book for nonscientists as well as scientists with little background knowledge in gene cloning, providing a wealth of information for anyone wishing to gain proficiency in reading and speaking the language of gene cloning.
	Animal Physiology: From Genes to Organisms by: Lauralee Sherwood publisher: Brooks Cole, published: 2012-01-01 ASIN: 0840068654 EAN: 9780840068651 sales rank: 469269 Keep up with today's rapid advances in the biological sciences with ANIMAL PHYSIOLOGY: FROM GENES TO ORGANISMS 2E with CourseMate! With coverage of animal species that will be relevant to your animal-related career, this biology text provides you with the tools you need to succeed. Boxes found throughout the text such as Molecular Biology and Genomics, Beyond the Basics, Challenges and Controversies, Unanswered Questions, and A Closer Look at Adaptation give you examples of cutting-edge research and help you see how what you are learning applies to the real world. Check Your Understanding questions after each major section help you review the main ideas as you read. Each chapter then ends with a Chapter Summary, a set of Review, Synthesize, and Analyze questions, and a list of Suggested Readings for further study.
	Gene Targeting and Embryonic Stem Cells (Advanced Methods) by: Jim Mcwhir publisher: Taylor & Francis, published: 2004-03-01 ASIN: 1859963609 EAN: 9781859963609 sales rank: 1519625 Gene Targeting and Embryonic Stem Cells is a practical guide designed for the rapidly growing number of researchers who are moving into this field. Provides details on how to culture, transfect and differentiate established cell lines, and how to isolate new cell lines.  Gene targeting experiments are described for a number of cell types, including ungulate fetal fibroblasts, murine ES cells, human embryonal carinoma cells and human ES cells, and include protocols for gene-targeting vectors, DNA transfection and RNA interference.

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