genetics-method books

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Molecular Methods for Evolutionary Genetics (Methods in Molecular Biology)

publisher: Humana Press, published: 2011-09-29
ASIN: 1617792276
EAN: 9781617792274
sales rank: 284939
We are entering a particularly fruitful period in evolutionary genetics, as rapid technological progress transforms the investigation of genetic variation within and between species. Molecular Methods for Evolutionary Genetics is a collection of advanced molecular biology protocols and general overviews intended to represent the essential methods currently bringing evolutionary genetics to fruition. Divided into six thematic sections, this volume covers methods for characterizing genomes, diverse approaches to enrich DNA for subsets of the genome prior to sequencing, and state-of-the-art protocols for sampling genetic variation for genetic mapping studies and population genetic studies (RAD sequencing, Sequenom, microarrays, etc.). The volume concludes by focusing on methods to study candidate genes, from obtaining their sequences and analyzing their transcripts to experimentally manipulating their activities in vivo. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Molecular Methods for Evolutionary Genetics serves as a rich resource to biologists interested in evolution, whether they be specialists or beginners in molecular biology.

Molecular Genetics of Bacteria, Third Edition (Snyder, Molecular Genetics of Bacteria)

by: Larry Snyder
publisher: ASM Press, published: 2007-05-31
ASIN: 1555813992
EAN: 9781555813994
sales rank: 81932
This landmark volume provides the single most comprehensive and authoritative textbook on bacterial molecular genetics. Perfect for advanced undergraduate and graduate-level courses, the text presents the latest research on the subject in a clearly written and well-illustrated style. It provides descriptive background information, detailed experimental methods, examples of genetic analyses, and advanced material relevant to current applications of molecular genetics. While providing a deep understanding of bacterial molecular genetics, the material is integrated with biochemical, genomic, and structural information to broaden understanding. The approach centers on the most-studied bacteria, Escherichia coli and Bacillus subtilis. In addition, examples from other bacteria with medical, ecological, or biotechnological significance are covered throughout the text. The material in each chapter has been substantially revised and rewritten and reflects exciting developments in the field of bacterial molecular genetics and its relationship to other fields, including genetics, biotechnology, and bioengineering. Molecular Genetics of Bacteria, 3rd Edition is organized like the two previous editions. Each chapter contains a summary of main points, descriptions of significant experiments, a set of discussion questions and a problem set (with answers to both at the back of the book), and a list of suggested readings-all updated to reflect the most recent advances in the field. Additionally, text boxes present intriguing information on each topic without interrupting the continuity of the text. This third edition is invaluable to anyone working in the fields of microbiology, genetics, biochemistry, bioengineering, medicine, molecular biology, and biotechnology. It is also essential reading for scientists in all fields of biology, many of whom depend upon the concepts and techniques covered in this book. New in the Third Edition* Features completely revised and updated material, incorporating the most recent advances in the field since publication of the second edition in 2002* Introduces over 100 brand-new illustrations* Offers a revised and expanded glossary containing approximately 1,000 entries Key Features and Benefits* Each chapter includes a concise end-of-chapter summary of the material covered* Incorporates text boxes that introduce readers to exciting developments and related topics of interest* Provides thought questions, problems, and suggested reading lists at the conclusion of each chapter that test student comprehension and encourage further research* Written by only two authors, both of whom are specialists in the field and who have significant experience teaching the subject of bacterial molecular genetics* Integrates biochemical, genomic, and structural information that broadens the knowledge obtained from molecular genetics* Focuses on the most widely studied bacteria, Escherichia coli and Bacillus subtilis, but incorporates many examples from other bacteria of medical, ecological, and biotechnological importance

Medical Genetics: With STUDENT CONSULT Online Access, 4e (MEDICAL GENETICS ( JORDE))

by: Lynn B. Jorde PhD
publisher: Mosby, published: 2009-09-28
ASIN: 0323053734
EAN: 9780323053730
sales rank: 133362

Medical Genetics is the clearest and most concise text on the subject, providing state-of-the-art coverage of clinically relevant molecular genetics. Lynn B. Jorde, PhD; John C. Carey, MD; and Michael J. Bamshad, MD integrate recent developments with clinical practice and emphasize the central principles of genetics and their clinical applications. Now in full color, this edition provides you with the stunning visual clarity so important in this field. Get the very latest on hot topics like gene identification, cancer genetics, gene testing and gene therapy, common diseases, ethical and social issues, personalized medicine, and much more. With Student Consult access, you'll get the full text online, along with images, 150 USMLE-style questions, and the clinical commentary and patient/family vignette boxes from the text-collated by chapter-for review. The accompanying Evolve site provides additional faculty notes, higher resolution images, 150 multiple choice questions, and 100 sample problems and essay questions. In other words, this is an indispensable resource that should be on every reading list.

Includes access to the complete text and images online at studentconsult.com along with 150 additional USMLE-style questions for self-assessment.

Features mini-summaries, study questions, suggested reading, and a detailed glossary to supplement and reinforce what you learn from the text.

Demonstrates clinical relevance through over 230 photographs, illustrations, and tables, along with boxes containing patient/family vignettes.

FOR FACULTY:

Supplements the text with online access to EVOLVE Resources.

Contains additional faculty notes, higher resolution images, 150 multiple choice questions, and 100 sample problems and essay questions online for teaching purposes.

Enhances the visual impact of the material with full-color illustrations throughout the text for easier and more effective learning and retention.

Presents a new chapter on genomics and personalized medicine for the latest on these hot topics.

Provides you with the latest knowledge and research on gene identification, cancer genetics, gene testing and gene therapy, common disorders, ethical and social issues, and much more so you can keep up with current developments in genetics.

Includes study questions at the end of every chapter so you can test yourself and retain the material.

Features additional clinically commentary boxes throughout the text to show the relevance of genetics to everyday patient problems to prepare you for problem-based integrated courses.

An Introduction to Forensic Genetics (Essential Forensic Science)

by: William Goodwin
publisher: Wiley, published: 2011-02-08
ASIN: 0470710195
EAN: 9780470710197
sales rank: 520382
This is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field.
Key Features:
Greater in-depth coverage of kinship problems now covered in two separate chapters: one dealing with relationships between living individuals and the other covering identification of human remains.
New chapter on non-human forensic genetics, including identification of bacteria and viruses, animals and plants.
Self assessment questions to aid student understanding throughout the text.
Now with full colour illustrations throughout
New companion website
Accessible introduction to forensic genetics, from the collection of evidence to the presentation of evidence in a legal context.
Included in the Forensic Science Society 'Essentials in Forensic Science' book series. This edition is to be included in the Forensic Science Society 'Essentials of Forensic Science' book series aimed at advanced level undergraduates and new practitioners to the field.

Statistical Methods in Genetic Epidemiology

by: Duncan C. Thomas
publisher: Oxford University Press, USA, published: 2004-01-29
ASIN: 019515939X
EAN: 9780195159394
sales rank: 476554
This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

Applied Statistical Genetics with R: For Population-based Association Studies (Use R!)

by: Andrea S. Foulkes
publisher: Springer, published: 2009-04-17
ASIN: 0387895531
EAN: 9780387895536
sales rank: 124005
Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

Likelihood, Bayesian and MCMC Methods in Quantitative Genetics (Statistics for Biology and Health)

by: Daniel Sorensen
publisher: Springer, published: 2010-12-01
ASIN: 1441929975
EAN: 9781441929976
sales rank: 680379
This book, suitable for numerate biologists and for applied statisticians, provides the foundations of likelihood, Bayesian and MCMC methods in the context of genetic analysis of quantitative traits. Although a number of excellent texts in these areas have become available in recent years, the basic ideas and tools are typically described in a technically demanding style and contain much more detail than necessary. Here, an effort has been made to relate biological to statistical parameters throughout, and the book includes extensive examples that illustrate the developing argument.

Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition

by: David C. Amberg
publisher: Cold Spring Harbor Laboratory Press, published: 2005-04-04
ASIN: 0879697288
EAN: 9780879697280
sales rank: 568962
Methods in Yeast Genetics is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.

Mathematical and Statistical Methods for Genetic Analysis

by: Kenneth Lange
publisher: Springer, published: 2002-03-28
ASIN: 0387953892
EAN: 9780387953892
sales rank: 1229922
Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research.
This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.

The Practical Guide to the Genetic Family History

by: Robin L. Bennett
publisher: Wiley-Blackwell, published: 2010-03-08
ASIN: 0470040726
EAN: 9780470040720
sales rank: 636541
Helps you develop and assess pedigrees to make diagnoses, evaluate risk, and counsel patients
The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical management and surveillance, and informing and educating patients. Based on the author's twenty-five years as a genetic counselor, the book also helps readers deal with the psychological, social, cultural, and ethical problems that arise in gathering a medical-family history and sharing findings with patients.
Featuring a new Foreword by Arno Motulsky, widely recognized as the founder of medical genetics, and completely updated to reflect the most recent findings in genetic medicine, this Second Edition presents the latest information and methods for preparing and assessing a pedigree, including:
Value and utility of a thorough medical-family history
Directed questions to ask when developing a medical-family history for specific disease conditions
Use of pedigrees to identify individuals with an increased susceptibility to cancer
Verification of family medical information
Special considerations when adoptions or gamete donors are involved
Ethical issues that may arise in recording a pedigree
Throughout the book, clinical examples based on hypothetical families illustrate key concepts, helping readers understand how real issues present themselves and how they can be resolved.
This book will enable all healthcare providers, including physicians, nurses, medical social workers, and physician assistants, as well as genetic counselors, to take full advantage of the pedigree as a primary tool for making a genetic risk assessment and providing counseling for patients and their families.

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	Molecular Methods for Evolutionary Genetics (Methods in Molecular Biology) publisher: Humana Press, published: 2011-09-29 ASIN: 1617792276 EAN: 9781617792274 sales rank: 284939 We are entering a particularly fruitful period in evolutionary genetics, as rapid technological progress transforms the investigation of genetic variation within and between species. Molecular Methods for Evolutionary Genetics is a collection of advanced molecular biology protocols and general overviews intended to represent the essential methods currently bringing evolutionary genetics to fruition. Divided into six thematic sections, this volume covers methods for characterizing genomes, diverse approaches to enrich DNA for subsets of the genome prior to sequencing, and state-of-the-art protocols for sampling genetic variation for genetic mapping studies and population genetic studies (RAD sequencing, Sequenom, microarrays, etc.). The volume concludes by focusing on methods to study candidate genes, from obtaining their sequences and analyzing their transcripts to experimentally manipulating their activities in vivo. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Molecular Methods for Evolutionary Genetics serves as a rich resource to biologists interested in evolution, whether they be specialists or beginners in molecular biology.
	Molecular Genetics of Bacteria, Third Edition (Snyder, Molecular Genetics of Bacteria) by: Larry Snyder publisher: ASM Press, published: 2007-05-31 ASIN: 1555813992 EAN: 9781555813994 sales rank: 81932 This landmark volume provides the single most comprehensive and authoritative textbook on bacterial molecular genetics. Perfect for advanced undergraduate and graduate-level courses, the text presents the latest research on the subject in a clearly written and well-illustrated style. It provides descriptive background information, detailed experimental methods, examples of genetic analyses, and advanced material relevant to current applications of molecular genetics. While providing a deep understanding of bacterial molecular genetics, the material is integrated with biochemical, genomic, and structural information to broaden understanding. The approach centers on the most-studied bacteria, Escherichia coli and Bacillus subtilis. In addition, examples from other bacteria with medical, ecological, or biotechnological significance are covered throughout the text. The material in each chapter has been substantially revised and rewritten and reflects exciting developments in the field of bacterial molecular genetics and its relationship to other fields, including genetics, biotechnology, and bioengineering. Molecular Genetics of Bacteria, 3rd Edition is organized like the two previous editions. Each chapter contains a summary of main points, descriptions of significant experiments, a set of discussion questions and a problem set (with answers to both at the back of the book), and a list of suggested readings-all updated to reflect the most recent advances in the field. Additionally, text boxes present intriguing information on each topic without interrupting the continuity of the text. This third edition is invaluable to anyone working in the fields of microbiology, genetics, biochemistry, bioengineering, medicine, molecular biology, and biotechnology. It is also essential reading for scientists in all fields of biology, many of whom depend upon the concepts and techniques covered in this book. New in the Third Edition* Features completely revised and updated material, incorporating the most recent advances in the field since publication of the second edition in 2002* Introduces over 100 brand-new illustrations* Offers a revised and expanded glossary containing approximately 1,000 entries Key Features and Benefits* Each chapter includes a concise end-of-chapter summary of the material covered* Incorporates text boxes that introduce readers to exciting developments and related topics of interest* Provides thought questions, problems, and suggested reading lists at the conclusion of each chapter that test student comprehension and encourage further research* Written by only two authors, both of whom are specialists in the field and who have significant experience teaching the subject of bacterial molecular genetics* Integrates biochemical, genomic, and structural information that broadens the knowledge obtained from molecular genetics* Focuses on the most widely studied bacteria, Escherichia coli and Bacillus subtilis, but incorporates many examples from other bacteria of medical, ecological, and biotechnological importance
	Medical Genetics: With STUDENT CONSULT Online Access, 4e (MEDICAL GENETICS ( JORDE)) by: Lynn B. Jorde PhD publisher: Mosby, published: 2009-09-28 ASIN: 0323053734 EAN: 9780323053730 sales rank: 133362 Medical Genetics is the clearest and most concise text on the subject, providing state-of-the-art coverage of clinically relevant molecular genetics. Lynn B. Jorde, PhD; John C. Carey, MD; and Michael J. Bamshad, MD integrate recent developments with clinical practice and emphasize the central principles of genetics and their clinical applications. Now in full color, this edition provides you with the stunning visual clarity so important in this field. Get the very latest on hot topics like gene identification, cancer genetics, gene testing and gene therapy, common diseases, ethical and social issues, personalized medicine, and much more. With Student Consult access, you'll get the full text online, along with images, 150 USMLE-style questions, and the clinical commentary and patient/family vignette boxes from the text-collated by chapter-for review. The accompanying Evolve site provides additional faculty notes, higher resolution images, 150 multiple choice questions, and 100 sample problems and essay questions. In other words, this is an indispensable resource that should be on every reading list. Includes access to the complete text and images online at studentconsult.com along with 150 additional USMLE-style questions for self-assessment. Features mini-summaries, study questions, suggested reading, and a detailed glossary to supplement and reinforce what you learn from the text. Demonstrates clinical relevance through over 230 photographs, illustrations, and tables, along with boxes containing patient/family vignettes. FOR FACULTY: Supplements the text with online access to EVOLVE Resources. Contains additional faculty notes, higher resolution images, 150 multiple choice questions, and 100 sample problems and essay questions online for teaching purposes. Enhances the visual impact of the material with full-color illustrations throughout the text for easier and more effective learning and retention. Presents a new chapter on genomics and personalized medicine for the latest on these hot topics. Provides you with the latest knowledge and research on gene identification, cancer genetics, gene testing and gene therapy, common disorders, ethical and social issues, and much more so you can keep up with current developments in genetics. Includes study questions at the end of every chapter so you can test yourself and retain the material. Features additional clinically commentary boxes throughout the text to show the relevance of genetics to everyday patient problems to prepare you for problem-based integrated courses.
	An Introduction to Forensic Genetics (Essential Forensic Science) by: William Goodwin publisher: Wiley, published: 2011-02-08 ASIN: 0470710195 EAN: 9780470710197 sales rank: 520382 This is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field. Key Features: Greater in-depth coverage of kinship problems now covered in two separate chapters: one dealing with relationships between living individuals and the other covering identification of human remains. New chapter on non-human forensic genetics, including identification of bacteria and viruses, animals and plants. Self assessment questions to aid student understanding throughout the text. Now with full colour illustrations throughout New companion website Accessible introduction to forensic genetics, from the collection of evidence to the presentation of evidence in a legal context. Included in the Forensic Science Society 'Essentials in Forensic Science' book series. This edition is to be included in the Forensic Science Society 'Essentials of Forensic Science' book series aimed at advanced level undergraduates and new practitioners to the field.
	Statistical Methods in Genetic Epidemiology by: Duncan C. Thomas publisher: Oxford University Press, USA, published: 2004-01-29 ASIN: 019515939X EAN: 9780195159394 sales rank: 476554 This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.
	Applied Statistical Genetics with R: For Population-based Association Studies (Use R!) by: Andrea S. Foulkes publisher: Springer, published: 2009-04-17 ASIN: 0387895531 EAN: 9780387895536 sales rank: 124005 Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.
	Likelihood, Bayesian and MCMC Methods in Quantitative Genetics (Statistics for Biology and Health) by: Daniel Sorensen publisher: Springer, published: 2010-12-01 ASIN: 1441929975 EAN: 9781441929976 sales rank: 680379 This book, suitable for numerate biologists and for applied statisticians, provides the foundations of likelihood, Bayesian and MCMC methods in the context of genetic analysis of quantitative traits. Although a number of excellent texts in these areas have become available in recent years, the basic ideas and tools are typically described in a technically demanding style and contain much more detail than necessary. Here, an effort has been made to relate biological to statistical parameters throughout, and the book includes extensive examples that illustrate the developing argument.
	Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, 2005 Edition by: David C. Amberg publisher: Cold Spring Harbor Laboratory Press, published: 2005-04-04 ASIN: 0879697288 EAN: 9780879697280 sales rank: 568962 Methods in Yeast Genetics is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.
	Mathematical and Statistical Methods for Genetic Analysis by: Kenneth Lange publisher: Springer, published: 2002-03-28 ASIN: 0387953892 EAN: 9780387953892 sales rank: 1229922 Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research. This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.
	The Practical Guide to the Genetic Family History by: Robin L. Bennett publisher: Wiley-Blackwell, published: 2010-03-08 ASIN: 0470040726 EAN: 9780470040720 sales rank: 636541 Helps you develop and assess pedigrees to make diagnoses, evaluate risk, and counsel patients The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical management and surveillance, and informing and educating patients. Based on the author's twenty-five years as a genetic counselor, the book also helps readers deal with the psychological, social, cultural, and ethical problems that arise in gathering a medical-family history and sharing findings with patients. Featuring a new Foreword by Arno Motulsky, widely recognized as the founder of medical genetics, and completely updated to reflect the most recent findings in genetic medicine, this Second Edition presents the latest information and methods for preparing and assessing a pedigree, including: Value and utility of a thorough medical-family history Directed questions to ask when developing a medical-family history for specific disease conditions Use of pedigrees to identify individuals with an increased susceptibility to cancer Verification of family medical information Special considerations when adoptions or gamete donors are involved Ethical issues that may arise in recording a pedigree Throughout the book, clinical examples based on hypothetical families illustrate key concepts, helping readers understand how real issues present themselves and how they can be resolved. This book will enable all healthcare providers, including physicians, nurses, medical social workers, and physician assistants, as well as genetic counselors, to take full advantage of the pedigree as a primary tool for making a genetic risk assessment and providing counseling for patients and their families.