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by: Jonathan Pevsner
publisher: Wiley-Blackwell, published: 2009-05-04
ASIN: 0470085851
EAN: 9780470085851
sales rank: 56467
The bestselling introduction to bioinformatics and functional genomics—now in an updated editionWidely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research. This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: - Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions.
- A completely updated companion web site, which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics
- Descriptions of genome sequencing projects spanning the tree of life.
- A stronger focus on how bioinformatics tools are used to understand human disease.
The book is complemented by lavish illustrations and more than 500 figures and tables—fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics. Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases. Praise for the first edition: "...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology "… an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering "…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" E-Streams
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by: Arthur Lesk
publisher: Oxford University Press, USA, published: 2012-04-26
ASIN: 0199564353
EAN: 9780199564354
sales rank: 466075
Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life?
Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.
Covering the latest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of chapter weblems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner.
The field of genomics is enabling us to analyze life in more detail than ever before; Introduction to Genomics is the perfect guide to this enthralling subject.
Online Resource Centre The Online Resource Centre to accompany Introduction to Genomics features
For lecturers: Figures from the book in electronic format
For students: Answers to end-of-chapter exercises Guided tour of web sites in genomics Hints to end-of-chapter problems Rotating figures
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by: A. Malcolm Campbell
publisher: Benjamin Cummings, published: 2006-03-12
ASIN: 0805382194
EAN: 9780805382198
sales rank: 108786
KEY BENEFIT: Discovering Genomics is the first genomics text that combines web activities and case studies with a problem-solving approach to teach upper-level undergraduates and first-year graduate students the fundamentals of genomic analysis. More of a workbook than a traditional text, Discovering Genomics, Second Edition allows students to work with real genomic data in solving problems and provides the user with an active learning experience. KEY TOPICS: Genomic Medicine Case Study: What’s wrong with my child? Genome Sequence Acquisition and Analysis, Comparative Genomics in Evolution and Medicine, Genome Variations, Genomic Medicine Case Study: Why Can’t I Just Take a Pill to Lose Weight? Basic Research with DNA Microarrays, Applied Research with DNA Microarrays, Proteomics, Genomic Medicine Case Study: Why Can’t We Cure More Diseases? Genomic Circuits in Single Genes, Integrated Genomic Circuits, Modeling Whole-Genome Circuits. MARKET: For all readers interested in genomics.
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by: Daniel L. Hartl
publisher: Jones & Bartlett Publishers, published: 2009-12-30
ASIN: 0763773646
EAN: 9780763773649
sales rank: 92164
Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.
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by: Jean F. Jenkins
publisher: Jones and Bartlett Publishers, Inc., published: 2004-11-25
ASIN: 0763733253
EAN: 9780763733254
sales rank: 526490
Increasingly, genomic-based approaches and resources are redefining our categorization of disease, leading to new approaches to prevention and therapy. As nurses traditionally practice patient-oriented care, they will undoubtedly play a key role in both developing and applying the aspects of genomic health care. Nursing Care in the Genomic Era: A Case Based Approach is designed to provide nurses with up-to-date and accessible information on this powerful new approach to understanding, preventing, and treating disease.
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by: David J. Dabbs MD
publisher: Saunders, published: 2010-01-29
ASIN: 1416057668
EAN: 9781416057666
sales rank: 176612
Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. - Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
- Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization.
- Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors.
- Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance.
- Features an expert author for each chapter to ensure coverage of the current state of the art.
- Includes access to the full text online at expertconsult.com, along with a downloadable image bank and Path Consult.
- Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches.
- Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results.
- Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin's lymphoma.
- Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
- Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms.
- Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.
Accurately interpret immunohistochemical results and provide the clinician with the best therapeutic approaches for the patient Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
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by: Michael A. Fortun
publisher: University of California Press, published: 2008-09-02
ASIN: 0520247515
EAN: 9780520247512
sales rank: 427249
Part detective story, part exposé, and part travelogue, Promising Genomics investigates one of the signature biotech stories of our time and, in so doing, opens a window onto the high-speed, high-tech, and high-finance world of genome science. In a luminous account, Mike Fortun investigates how deCODE Genetics, in Iceland, became one of the wealthiest companies of its kind, as well as one of the most scandalous, with its plan to use the genes and medical records of the entire Icelandic population for scientific research. Delving into the poetry of W. H. Auden, the novels of Halldór Laxness, and the perils of Keiko the killer whale, Fortun maps the contemporary genomics landscape at a time when we must begin to ask questions about what "life" is made of in the age of DNA, databases, and derivatives trading.
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publisher: Springer, published: 2010-11-19
ASIN: 1441924760
EAN: 9781441924766
sales rank: 478470
Soybean genomics is of great interest as one of the most economically important crops and a major food source. This book covers recent advances in soybean genome research, including classical, RFLP, SSR, and SNP markers; genomic and cDNA libraries; functional genomics platforms; genetic and physical maps; and gene expression profiles. The book is for researchers and students in plant genetics and genomics, plant biology and pathology, agronomy, and food sciences.
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by: Nello Cristianini
publisher: Cambridge University Press, published: 2007-01-15
ASIN: 0521671914
EAN: 9780521671910
sales rank: 613007
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
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by: Misha Angrist
publisher: Harper, published: 2010-11-01
ASIN: B0058M5HY4
sales rank: 471315
The first in-depth look at personal genomics: its larger-than-life research subjects; its entrepreneurs and do-it-yourselfers; its technology developers; the bewildered and overwhelmed physicians and regulators who must negotiate it; and what it means to be a "public genome" in a world where privacy is already under siege In 2007, Misha Angrist became the fourth subject in the Personal Genome Project, George Church's ambitious plan to sequence the entire genomic catalog: every participant's twenty thousand–plus genes and the rest of his or her 6 billion base pairs. Church hopes to better understand how genes influence our physical traits, from height and athletic ability to behavior and weight, and our medical conditions, from cancer and diabetes to obesity and male pattern baldness. Now Angrist reveals startling information about the experiment's participants and scientists; how the experiment was, is, and will be conducted; the discoveries and potential discoveries; and the profound implications of having an unfiltered view of our hardwired selves for us and for our children. DNA technology has already changed our health care, the food we eat, and our criminal justice system. Unlocking the secrets of our genomes opens the door not only to helping us understand why we are the way we are and potentially fixing what ails us but also to many other concerns: What exactly will happen to this information? Will it become just another marketing tool? Can it help us understand our ancestry, or will it merely reinforce old ideas of race? Can personal genomics help fix the U.S. health care system? Here Is a Human Being explores these complicated questions while documenting Angrist's own fascinating journey—one that tens of thousands of us will soon make.
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