Related books on 'mutation-analysis'
Return to life science book listNumber of products: 7023
Page 1 of 703
|
by: Norah Rudin publisher: CRC Press, published: 2001-12-21 ASIN: 0849302331 EAN: 9780849302336 sales rank: 568085 Significant advances in DNA analysis techniques have surfaced since the 1997 publication of the bestselling An Introduction to Forensic DNA Analysis. DNA typing has become increasingly automated and miniaturized. Also, with the advent of Short Tandem Repeat (STR) technology, even the most minute sample of degraded DNA can yield a profile, providing valuable case information. However, just as the judicial system slowly and reluctantly accepted RFLP and AmpliType® PM+DQA1 typing, it is now scrutinizing the admissibility of STRs. Acknowledging STR typing as the current system of choice, An Introduction to Forensic DNA Analysis, Second Edition translates new and established concepts into plain English so that laypeople can gain insight into how DNA analysis works, from sample collection to interpretation of results. In response to the shift toward more efficient techniques, the authors cover the legal admissibility of STR typing, expand the chapter on DNA databases, and revise the section on automated analysis. They also present key decisions and appellate or supreme court rulings that provide precedent at the state and federal levels. Discussing forensic DNA issues from both a scientific and a legal perspective, the authors of An Introduction to Forensic DNA Analysis, Second Edition present the material in a manner understandable by professionals in the legal system, law enforcement, and forensic science. They cover general principles in a clear fashion and include a glossary of terms and other useful appendices for easy reference. |
|
by: Michael Lynch publisher: Sinauer Associates, published: 1998-01-06 ASIN: 0878934812 EAN: 9780878934812 sales rank: 403567 Genetics and Analysis of Quantitative Traits brings together the diverse array of theoretical and empirical applications of quantitative genetics under one cover, in a way that is both comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics. What was originally envisioned as a single text has now become two, with the focus of this first book being on the basic biology and methods of analysis of quantitative characters. (The second book, Evolution and Selection of Quantitative Traits, will address the basic principles that govern the evolutionary dynamics of quantitative characters under the forces of mutation, random genetic drift, and natural and/or artificial selection, integrating the theory of evolution of such characters with existing empirical data from natural and domesticated plant and animal populations.) Written as a general text in quantitative genetics, the book will also be useful as a basic reference for the seasoned professional. Throughout, central theoretical concepts are developed from first principles. To aid the less statistically sophisticated reader, several chapters and appendices focus on the basic statistical tools needed to digest the book. Wherever possible, theoretical and analytical concepts are illustrated with empirical examples from diverse settings. Three major features of Genetics and Analysis of Quantitative Traits distinguish it from earlier work. First, it reflects the explosive influx over the past few years of quantitative-genetic thinking into evolutionary biology. Second, in animal breeding, enormous strides have been made in the development of new techniques for estimating breeding values (for the purposes of identifying elite individuals in selection programs) and for estimating variance components from samples of complex pedigrees. In this text's last two chapters, the authors outline the basic principles of complex pedigree analysis, without getting bogged down in technical details. Third, Genetics and Analysis of Quantitative Traits provides a broad overview of the newly emerging array of techniques for quantitative-trait loci (QTL) analysis, currently one of the most active fields of quantitative-genetic research. Genetics and Analysis of Quantitative Traits contains numerous fully-worked examples and illustrations of theoretical concepts, as well as over 2,000 references with indices by subject, author, and organism. In addition, the authors maintain a World Wide Web site featuring up-to-date lists of computer programs and on-line resources, and added information on various topics presented in the text. |
|
by: Haig H. Kazazian publisher: FT Press, published: 2011-03-31 ASIN: 0137070624 EAN: 9780137070626 sales rank: 1113394 This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field.
Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding. |
|
by: Virginia E. Papaioannou publisher: Cold Spring Harbor Laboratory Press, published: 2004-11-01 ASIN: 0879696400 EAN: 9780879696405 sales rank: 1349463 The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step by step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects. |
|
by: Mauro Pezze publisher: Wiley, published: 2007-04-13 ASIN: 0471455938 EAN: 9780471455936 sales rank: 125292 The first comprehensive book on software test and analysis You can't "test quality into" a software product, but neither can you build a quality software product without test and analysis. Software test and analysis is increasingly recognized, in research and in industrial practice, as a core challenge in software engineering and computer science. Software Testing and Analysis: Process, Principles, and Techniques is the first book to present a range of complementary software test and analysis techniques in an integrated, coherent fashion. It covers a full spectrum of topics from basic principles and underlying theory to organizational and process issues in real-world application. The emphasis throughout is on selecting a complementary set of practical techniques to achieve an acceptable level of quality at an acceptable cost. Highlights of the book include * Interplay among technical and non-technical issues in crafting an approach to software quality, with chapters devoted to planning and monitoring the software quality process. * A selection of practical techniques ranging from inspection to automated program and design analyses to unit, integration, system, and regression testing, with technical material set in the context of real-world problems and constraints in software development. * A coherent view of the state of the art and practice, with technical and organizational approaches to push the state of practice toward the state of the art. Throughout, the text covers techniques that are suitable for near-term application, with sufficient technical background to help you know how and when to apply them. Exercises reinforce the instruction and ensure that you master each topic before proceeding. By incorporating software testing and analysis techniques into modern practice, Software Testing and Analysis: Process, Principles, and Techniques provides both students and professionals with realistic strategies for reliable and cost-effective software development. |
|
publisher: Springer, published: 2011-10-25 ASIN: 1461407818 EAN: 9781461407812 sales rank: 257410 Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein – DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging. |
|
by: R. Scott Hawley publisher: Wiley-Blackwell, published: 2003-01 ASIN: 1405103361 EAN: 9781405103367 sales rank: 723098 Advanced Genetic Analysis brings a state-of-the-art, exciting new approach to genetic analysis. Focusing on the underlying principles of modern genetic analysis, this book provides the 'how' and 'why' of the essential analytical tools needed. The author's vibrant, accessible style provides an easy guide to difficult genetic concepts, from mutation and gene function to gene mapping and chromosome segregation. Throughout, a balanced range of model organisms and timely examples are used to illustrate the theoretical basics.
|
|
by: Elof Axel Carlson publisher: Cold Spring Harbor Laboratory Pr, published: 2011-06-03 ASIN: 1936113309 EAN: 9781936113309 sales rank: 446715 Today, most scientists regard the term "mutation" as a description of a change in an individual gene, and more precisely as some minute alteration of the DNA of that gene, especially a nucleotide substitution. But the idea of mutation has changed considerably from the pre-Mendelian concepts of Darwin's generation, who viewed "fluctuating variations" as the raw material on which evolution acted, to today's up-to-the-minute genomic context of mutation. History of Mutation: From Darwinian Fluctuations to Comparative Genomics explores six generations of mutation research, providing the background-the people and the ideas---for this biological journey. After exploring Darwin's and Francis Galton's concepts of mutation, Carlson shows how the 1900 rediscovery of Gregor Mendel's experiments let to a discontinuous model of evolution by mutation and how cytological investigations led to the chromosome theory of heredity of classical genetics in which there was random mutation in genes. Carlson details how Mendelian and biometric approaches to heredity and evolution were closely tied and how induction of mutations by radiation and chemical mutagens led to biochemical investigations of gene action, shifting attention to the chemistry of the gene. The interpretation of the gene as DNA and the deciphering of the genetic code then gave rise to molecular interpretations of mutation, views that also impacted evolutionary biology, population genetics, commercial development of plants and animals, and human genetics. This book shows how generational definitions or assessments of mutation have responded to the technologies added to science and the experiments that abounded with the inquiries of each successive generation. These observations are combined with an exploration of how the nonscientific public has shifted its understanding and concern about mutations over the past 150 or more years. Carlson's historical approach in this book-examining the evolution of a concept-reveals the way science works, incrementally by small steps of additions and replacements rather than by dramatic, and rare, paradigm shifts. |
|
by: Philip Meneely publisher: Oxford University Press, USA, published: 2009-03-15 ASIN: 0199219826 EAN: 9780199219827 sales rank: 474996 How can we explore gene expression in time and space? How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? Advanced Genetic Analysis probes fascinating questions such as these by asking "How can the principles of genetics be used as analytical tools to solve biological problems?" With its unique integration of genetics and molecular biology, Advanced Genetic Analysis provides a broad survey of how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles and model organisms, the books goes on to explore the use of gene mutations and the analysis of gene expression and activity, before considering the interactions of genes during suppression and epistasis, and how we study gene networks. Drawing on the latest experimental tools, including microarrays, RNAi, and bioinformatics approaches, Advanced Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research without losing clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realize how much more there is still to understand. Advanced Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding. |
|
publisher: Wiley-Interscience, published: 2004-10-29 ASIN: 0471478784 EAN: 9780471478782 sales rank: 301852 Reviews of the Second Edition "In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt." --Eric Lander, from the Foreword to the Second Edition "The editors and the chapter authors of this book are to be applauded for providing biologists with lucid and comprehensive descriptions of essential topics in bioinformatics. This book is easy to read, highly informative, and certainly timely. It is most highly recommended for students and for established investigators alike, for anyone who needs to know how to access and use the information derived in and from genomic sequencing projects." --Trends in Genetics "It is an excellent general bioinformatics text and reference, perhaps even the best currently available . . . Congratulations to the authors, editors, and publisher for producing a weighty, authoritative, readable, and attractive book." --Briefings in Bioinformatics "This book, written by the top scientists in the field of bioinformatics, is the perfect choice for every molecular biology laboratory." --The Quarterly Review of Biology This fully revised version of a world-renowned bestseller provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms. Using relevant biological examples, the book provides background on and strategies for using many of the most powerful and commonly used computational approaches for biological discovery. This Third Edition reinforces key concepts that have stood the test of time while making the reader aware of new and important developments in this fast-moving field. With a new full-color and enlarged page design, Bioinformatics, Third Edition offers the most readable, up-to-date, and thorough introduction to the field for biologists. This new edition features: * New chapters on genomic databases, predictive methods using RNA sequences, sequence polymorphisms, protein structure prediction, intermolecular interactions, and proteomic approaches for protein identification * Detailed worked examples illustrating the strategic use of the concepts presented in each chapter, along with a collection of expanded,more rigorous problem sets suitable for classroom use * Special topic boxes and appendices highlighting experimental strategies and advanced concepts * Annotated reference lists, comprehensive lists of relevant Web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics Bioinformatics, Third Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, clinical research, proteomics, and computational biology. |