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by: Matt Carter
publisher: Academic Press, published: 2009-10-06
ASIN: 0123748496
EAN: 9780123748492
sales rank: 221878
Neuroscience is by definition a multidisciplinary field: some scientists study genes and proteins at the molecular level while others study neural circuitry. A single topic such as the auditory system can be studied using techniques from genetics, imaging, biochemistry, or electrophysiology. A young scientist must learn how to read the primary literature and then develop their own experiments. This book offers that scientist an overview of mainstream research techniques, provides guidelines on how to choose one technique over another, offers tips on analyzing data, and provides a list of references for additional detailed study. This book can also assist an experienced scientist understand published studies conducted outside their own subfield.*Written by Stanford University graduate students in neuroscience to provide a "hands-on" approach for other neuroscience graduate students *Techniques within one field will be compared so that user can select best technique for their experiment *Chapters include references (key articles, books, protocols) for additional detailed study *Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to represent results *"Walk-through" boxes guide students through the experiment step-by-step
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publisher: Humana Press, published: 2009-10-29
ASIN: 1607612917
EAN: 9781607612919
sales rank: 675863
Since the conception of this acclaimed series of volumes examining neural tissue culture, the expansion of neuroscience has continued to produce vital discoveries that utilize tissue culture methodologies. The expert contributors to the fourth edition of Protocols for Neural Cell Culture refine existing protocols and present the emerging new techniques and culture media formulations linked with the many advances in neuroscience. While highlighting updated experimental procedures for many of the classical neural tissue culture preps, the volume addresses topics such as regenerative medicine and the methods to grow and expand embryonic and adult neural stem cells. Essential techniques for the isolation, expansion, and cryopreservation of neural tissue from mouse, rat, and human sources are covered, as well as methods to assess aspects of cell function (calcium imaging) and cell death. With its detailed, step-by-step laboratory protocols, this volume provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Protocols for Neural Cell Culture, Fourth Edition continues the previous editions’ tradition of exceptional quality and thorough coverage in tissue culture protocols for today’s neuroscience in order to inspire researchers in the field to further explore this imperative area of study.
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by: Douglas Wahlsten
publisher: Academic Press, published: 2010-11-05
ASIN: 012375674X
EAN: 9780123756749
sales rank: 370520
This book presents the essentials of behavioral test methodology needed for effective study planning and high quality behavioral data collection on laboratory mice. The broad scope of behavioral testing in relation to the neurosciences is discussed, as are the fine details of various test situations. Mistakes made in past research are scrutinized and lessons are drawn about how to avoid them in future work. Diverse factors that can influence the results of behavioral experiments are discussed, ranging from the specific parameters employed in a test to the laboratory environment outside the test situation itself. Throughout the book, emphasis is placed on special issues that arise when testing genetically different mice, including inbred strains and mice with targeted mutations. This knowledge will assist an investigator who lacks formal training in behavioral psychology to build a behavioral testing lab and insure that its output meets current standards of good practice in behavioral neuroscience research. The book will be a convenient manual of procedures for daily use in studies of mouse behavior. It will be of interest even to experienced behavioural researchers, but of particular value to scientists just beginning work with mice, including undergraduate and graduate students as well as postdoctoral investigators who want to collect phenotypic data with knockout and other genetically defined mice. Constructed from materials used in a long running course on Advanced Animal Behavior at University of North Carolina-Greensboro, the book is an ideal text for a course on behavioral testing. * A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test. * Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas * Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully * A companion website will provide: access to statistical utilities in Excel and test protocols; examples of real documents used for published studies; video clips of the mice behaviors resulting from various tests
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by: Mary E. Harrington
publisher: Sage Publications, Inc, published: 2010-09-13
ASIN: 1412974321
EAN: 9781412974325
sales rank: 666731
“You are about to start on a great adventure. You are going to transition from reading about science to becoming a scientist.” -From the Preface Using engaging, disarming prose, author Mary Harrington shows neuroscience students how to go about selecting a topic, designing an experiment, analyzing the results, and publishing a paper. This text effectively illustrates basic research methods and design principles by uniquely using relevant examples from neuroscience such as the principles of design of fMRI studies, the use of transgenic mice, and conditional gene knockouts. The author also addresses basic professional ethics, fundamental statistics and data analysis tools, the range of possible experimental designs (from simple descriptive studies to multifactorial designs), and ways to control unwanted variables and avoid common pitfalls. This text is intended as either a core or supplemental text for both undergraduates and graduate students studying research methods in Neuroscience, Neuroanatomy, Neurophysiology, Neurochemistry, or Biological Psychology.
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publisher: Current Protocols, published: 2006-10-27
ASIN: 0471783978
EAN: 9780471783978
sales rank: 2039063
Short Protocols in Neuroscience: Systems and Behavioral Methods provides a portable and streamlined at-the-bench resource of systems and behavorial methods from the acclaimed Current Protocols in Neuroscience. It covers areas such as electrophysiological analysis of neural cells, the chemistry and pharmacology of the nervous system, behavioral analysis, and animal models of neurologic and psychiatric disorders.
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by: Charles R. Gerfen
publisher: Current Protocols, published: 2006-08-04
ASIN: 0471783994
EAN: 9780471783992
sales rank: 2227351
Short Protocols in Neuroscience: Cellular and Molecular Methods is an easy-to-use compendium of cellular and molecular methods from Current Protocols in Neuroscience, part of the acclaimed series that has set the standard for excellence for laboratory manuals. The title provides a portable and streamlined at-the-bench resource, covering methods for analysis of neural cell structure and function, isolation and culture of neural cells, and characterization of neural cell gene expression.
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by: American Association of Critical-Care Nurses (AACN)
publisher: Jones & Bartlett Publishers, published: 2008-01-28
ASIN: 0763741566
EAN: 9780763741563
sales rank: 1247877
AACN Protocols for Practice: Monitoring Neuroscience Patients provides clinicians at the point of care with the latest research findings in patient care in a format which is easy to understand and integrate into clinical practice. Each protocol guides clinicians in the appropriate selection of patients, use and application of management principles, initial and ongoing monitoring, discontinuation of therapies or interventions, and selected aspects of quality control.
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by: Stephen Waxman
publisher: Academic Press, published: 2004-11-01
ASIN: 0127389032
EAN: 9780127389035
sales rank: 1570036
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson's disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord.
The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone - clinicians and basic scientists alike - interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.
* Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field
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publisher: Cambridge University Press, published: 2010-06-14
ASIN: 0521517338
EAN: 9780521517331
sales rank: 476038
Latent inhibition is a phenomenon by which exposure to an irrelevant stimulus impedes the acquisition or expression of conditioned associations with that stimulus. Latent inhibition, an integral part of the learning process, is observed in many species. This comprehensive collection of studies of latent inhibition, from a variety of disciplines including behavioural/cognitive psychology, neuroscience and genetics, focuses on abnormal latent inhibition effects in schizophrenic patients and schizotypal normals. Amongst other things, the book addresses questions such as, is latent inhibition an acquisition or performance deficit? What is the relationship of latent inhibition to habituation, extinction, and learned irrelevance? Does reduced latent inhibition predict creativity? What are the neural substrates, pharmacology, and genetics of latent inhibition? What do latent inhibition research and theories tell us about schizophrenia? This book provides a single point of reference for neuroscience researchers, graduate students, and professionals, such as psychologists and psychiatrists.
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publisher: Academic Press, published: 2008-03-14
ASIN: 0123736498
EAN: 9780123736499
sales rank: 1758652
Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). The book should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.
* Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures * Contributors are top experts at the forefront of computational epilepsy research * Chapter contents are highly relevant to both basic and clinical epilepsy researchers
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