pharmacogenomics books

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Psychiatric Pharmacogenomics

by: David Mrazek MD
publisher: Oxford University Press, USA, published: 2010-05-28
ASIN: 0195367294
EAN: 9780195367294
sales rank: 512956
Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication.

The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients.

The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes.

The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Pharmacogenomics, Second Edition (Drugs and the Pharmaceutical Sciences)

publisher: Informa Healthcare, published: 2005-09-02
ASIN: 1574448781
EAN: 9781574448788
sales rank: 798571

Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.

Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-19
ASIN: 1617378259
EAN: 9781617378256
sales rank: 1635437
The field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. The volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. This book is ideal for scientists striving to transform disease treatment into disease prevention.

Principles of Pharmacogenetics and Pharmacogenomics

publisher: Cambridge University Press, published: 2012-01-23
ASIN: 052188537X
EAN: 9780521885379
sales rank: 1015136
The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together contributions from leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. The first section of the book outlines critical concepts in pharmacogenetics and pharmacogenomics, including genetic testing, genotyping technologies, and adverse drug effects. The next section discusses the legal, ethical, and social implications of pharmacogenomics. The second half of the book details many of the main therapeutic areas, including oncologic drugs, cardiovascular drugs, statins, drug-induced long QT syndrome, diabetes drugs, respiratory drugs, gastrointestinal drugs, rheumatoid arthritis drugs, obstetric drugs, psychiatric drugs, pain and anesthesia drugs, HIV and antiretroviral drugs, pediatrics, and fetal and neonatal medicine. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences. RESOURCES @ www.cambridge.org/altman • Link to the Pharmacogenomics Knowledgebase • study guides • images from the book • discussion questions • content updates.

Concepts in Pharmacogenomics (Zdanowicz, Concepts in Pharmacogenomics)

by: Martin M. Zdanowicz Ph.D. M.A.
publisher: American Society of Health-System Pharmacists, published: 2010-01-01
ASIN: 1585282340
EAN: 9781585282340
sales rank: 753164
The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time. If you are pharmacist, resident, or student curious about this new field, start with Concepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application.

Pharmacogenomics in Clinical Therapeutics

publisher: Wiley, published: 2012-02-28
ASIN: 0470657340
EAN: 9780470657348
Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice of personalized medicine. An important new book, Pharmacogenomics in Clinical Therapeutics serves as a guide to the basic principles of pharmacogenomics in a range of common therapeutic areas and as the basis of the personalized medicine of the future.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response (Cancer Drug Discovery and Development)

publisher: Humana Press, published: 2010-11-19
ASIN: 1617376949
EAN: 9781617376948
sales rank: 2399379
The availability of new molecular approaches to the selection of drug therapy is an emerging need, as the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many, and in most cases the majority of treated patients do not have significant benefits from the treatment while they often experience moderate to severe toxicities. In “Pharmacogenomics, Anticancer Drug Discovery, and Response”, edited by Federico Innocenti, readers will find a series of chapters addressing the role of genomic information in cancer therapy and in drug development representing a unique source, as it describes experimental approaches, statistical strategies, and clinical examples of the application of genomic medicine in oncology. This book provides the most comprehensive body of knowledge on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients.

Pharmacogenomics: Methods and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-19
ASIN: 1617375713
EAN: 9781617375712
sales rank: 4721444
Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

Pharmacogenomics of Alcohol and Drugs of Abuse

publisher: CRC Press, published: 2012-04-26
ASIN: 1439856117
EAN: 9781439856116

Pharmacogenomics is the basis of personalized medicine, which is said to be the medicine of the future. Understanding genetic variation in alcohol response is vital for professionals involved in alcohol rehabilitation programs. This volume focuses on how pharmacogenomic principles are applied to alcohol and drug testing and treatment and discusses the role of the clinical laboratory in the practice of personalized medicine. With contributions from a range of experts, the text presents the genetic aspects of alcohol metabolism and drugs of abuse, including marijuana, cocaine, and amphetamine. It also covers methodologies in pharmacogenomic testing.

Pharmacogenomics and Personalized Medicine (Methods in Pharmacology and Toxicology)

publisher: Humana Press, published: 2010-11-09
ASIN: 1617379212
EAN: 9781617379215
sales rank: 2350266
With all the multitude of challenges facing the pharmaceutical research and development process, the industry is actively exploring the relationships between human genetics and drug responsiveness, susceptibility to disease and disease severity. In Pharmacogenomics and Personalized Medicine, leading experts from the pharmaceutical industry, the scientific community and the government provide guidance for conducting pharmacogenomic research from discovery to the market, while also presenting a realistic perspective on the challenges, practicalities and obstacles in its application. Focusing on DNA data and associated analytical methodologies, with a consideration for complementary RNA-based studies, this volume includes a wide array of vital, cutting-edge research. Comprehensive and timely, Pharmacogenomics and Personalized Medicine will assist novice and experienced investigators alike in the understanding of the current scientific challenges in applying pharmacogenomics to drug discovery and clinical development.

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	Psychiatric Pharmacogenomics by: David Mrazek MD publisher: Oxford University Press, USA, published: 2010-05-28 ASIN: 0195367294 EAN: 9780195367294 sales rank: 512956 Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.
	Pharmacogenomics, Second Edition (Drugs and the Pharmaceutical Sciences) publisher: Informa Healthcare, published: 2005-09-02 ASIN: 1574448781 EAN: 9781574448788 sales rank: 798571 Reflecting the shift from genetics to genomics in the pharmaceutical sphere, this Second Edition traces the evolution of the science of pharmacogenetics and gathers research from the forefront of the field-spanning the most influential breakthroughs in molecular diagnostics, metabonomics, proteomics, bioinformatics, disease mapping, pharmacodynamics, and disease gene identification.
	Pharmacogenomics in Drug Discovery and Development (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-19 ASIN: 1617378259 EAN: 9781617378256 sales rank: 1635437 The field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. The volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. This book is ideal for scientists striving to transform disease treatment into disease prevention.
	Principles of Pharmacogenetics and Pharmacogenomics publisher: Cambridge University Press, published: 2012-01-23 ASIN: 052188537X EAN: 9780521885379 sales rank: 1015136 The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together contributions from leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. The first section of the book outlines critical concepts in pharmacogenetics and pharmacogenomics, including genetic testing, genotyping technologies, and adverse drug effects. The next section discusses the legal, ethical, and social implications of pharmacogenomics. The second half of the book details many of the main therapeutic areas, including oncologic drugs, cardiovascular drugs, statins, drug-induced long QT syndrome, diabetes drugs, respiratory drugs, gastrointestinal drugs, rheumatoid arthritis drugs, obstetric drugs, psychiatric drugs, pain and anesthesia drugs, HIV and antiretroviral drugs, pediatrics, and fetal and neonatal medicine. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences. RESOURCES @ www.cambridge.org/altman • Link to the Pharmacogenomics Knowledgebase • study guides • images from the book • discussion questions • content updates.
	Concepts in Pharmacogenomics (Zdanowicz, Concepts in Pharmacogenomics) by: Martin M. Zdanowicz Ph.D. M.A. publisher: American Society of Health-System Pharmacists, published: 2010-01-01 ASIN: 1585282340 EAN: 9781585282340 sales rank: 753164 The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time. If you are pharmacist, resident, or student curious about this new field, start with Concepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application.
	Pharmacogenomics in Clinical Therapeutics publisher: Wiley, published: 2012-02-28 ASIN: 0470657340 EAN: 9780470657348 Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice of personalized medicine. An important new book, Pharmacogenomics in Clinical Therapeutics serves as a guide to the basic principles of pharmacogenomics in a range of common therapeutic areas and as the basis of the personalized medicine of the future.
	Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response (Cancer Drug Discovery and Development) publisher: Humana Press, published: 2010-11-19 ASIN: 1617376949 EAN: 9781617376948 sales rank: 2399379 The availability of new molecular approaches to the selection of drug therapy is an emerging need, as the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many, and in most cases the majority of treated patients do not have significant benefits from the treatment while they often experience moderate to severe toxicities. In “Pharmacogenomics, Anticancer Drug Discovery, and Response”, edited by Federico Innocenti, readers will find a series of chapters addressing the role of genomic information in cancer therapy and in drug development representing a unique source, as it describes experimental approaches, statistical strategies, and clinical examples of the application of genomic medicine in oncology. This book provides the most comprehensive body of knowledge on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients.
	Pharmacogenomics: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-19 ASIN: 1617375713 EAN: 9781617375712 sales rank: 4721444 Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
	Pharmacogenomics of Alcohol and Drugs of Abuse publisher: CRC Press, published: 2012-04-26 ASIN: 1439856117 EAN: 9781439856116 Pharmacogenomics is the basis of personalized medicine, which is said to be the medicine of the future. Understanding genetic variation in alcohol response is vital for professionals involved in alcohol rehabilitation programs. This volume focuses on how pharmacogenomic principles are applied to alcohol and drug testing and treatment and discusses the role of the clinical laboratory in the practice of personalized medicine. With contributions from a range of experts, the text presents the genetic aspects of alcohol metabolism and drugs of abuse, including marijuana, cocaine, and amphetamine. It also covers methodologies in pharmacogenomic testing.
	Pharmacogenomics and Personalized Medicine (Methods in Pharmacology and Toxicology) publisher: Humana Press, published: 2010-11-09 ASIN: 1617379212 EAN: 9781617379215 sales rank: 2350266 With all the multitude of challenges facing the pharmaceutical research and development process, the industry is actively exploring the relationships between human genetics and drug responsiveness, susceptibility to disease and disease severity. In Pharmacogenomics and Personalized Medicine, leading experts from the pharmaceutical industry, the scientific community and the government provide guidance for conducting pharmacogenomic research from discovery to the market, while also presenting a realistic perspective on the challenges, practicalities and obstacles in its application. Focusing on DNA data and associated analytical methodologies, with a consideration for complementary RNA-based studies, this volume includes a wide array of vital, cutting-edge research. Comprehensive and timely, Pharmacogenomics and Personalized Medicine will assist novice and experienced investigators alike in the understanding of the current scientific challenges in applying pharmacogenomics to drug discovery and clinical development.