Life science and biomedical books

Related books on 'protein-phosphorylation'

	Proteins: Structure and Function by: David Whitford publisher: Wiley, published: 2005-05-23 ASIN: 0471498947 EAN: 9780471498940 sales rank: 371812 Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
	Introduction to Proteins: Structure, Function, and Motion (Chapman & Hall/CRC Mathematical & Computational Biology) by: Amit Kessel publisher: CRC Press, published: 2010-12-17 ASIN: 1439810710 EAN: 9781439810712 sales rank: 219794 As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
	Proteomics of Biological Systems: Protein Phosphorylation Using Mass Spectrometry Techniques by: Bryan M. Ham publisher: Wiley, published: 2011-11-15 ASIN: 1118028961 EAN: 9781118028964 sales rank: 3480369 Phosphorylation is the addition of a phosphate (PO4) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation, mass spectral instrumental analysis, and data interpretation approaches. Furthermore, it includes the use of bioinformatic Internet tools such as the Blast2GO gene ontology (GO) tool, used to help understand and interpret complex data collected in these studies.
	Protein Phosphorylation (Selected Methods in Enzymology) publisher: Academic Press, published: 1998-05-01 ASIN: 0126344906 EAN: 9780126344905 sales rank: 3983708 Assembled in this volume are articles chosen from Methods in Enzymology Volumes 200 and 201 for their contemporary relevance and their usefulness to those new to the study of protein phosphorylation. Major topics include classification of protein kinases and protein phosphatases, assays of protein kinases and protein phosphorylation, purification and cloning of protein kinases and protein phosphatases, and the use of inhibitors of protein kinases and protein phosphatases. Key Features * Classification of Protein Kinases and Protein Phosphatases * Assays of Protein Kinases and Protein Phosphorylation * Purification and Cloning of Protein Kinases and Protein Phosphatases * Analysis and Identification of Phosphopeptides and Phosphoamino Acids
	Protein Phosphorylation Analysis by Electrospray Mass Spectrometry: A Guide to Concepts and Practice by: Wolf D Lehmann publisher: Royal Society of Chemistry, published: 2010-11-01 ASIN: 0854041850 EAN: 9780854041855 sales rank: 4293549 Protein phosphorylation analysis is a central theme in current analytical biochemistry, cell biology and systems biology. Due to its versatility, specificity and sensitivity, mass spectrometry has developed into a key technology in this field. A set of minor and major instrumental innovations mean that mass spectrometers now exhibit a level of performance, a stability of operation, a relative ease of use, and productivity, which would once have been hard to imagine. This book guides the reader through this prolific field by presenting a collection of personal views and selected examples which cover all the important principles with a focus on electrospray ionization mass spectrometry. It covers: phosphorylation analysis at the peptide, protein and proteome level; manual and automated data evaluation; phosphopeptide enrichment; quantitative aspects; element mass spectrometry; individual analytical strategies, and hints to useful internet resources. This book provides students, graduate students, post-Docs and senior scientists from related areas with a better understanding on molecular protein phosphorylation analysis. It's highest aim is to strengthen the reader's ability to develop a personal, well-founded opinion on original manuscripts published in this field.
	Protein Phosphorylation: A Practical Approach (Practical Approach Series) publisher: Oxford University Press, USA, published: 1993-06-03 ASIN: 0199633053 EAN: 9780199633050 sales rank: 8002736 Reversible phosphorylation is one of the major mechanisms by which protein activity is controlled in all eukaryotic cells. Networks of protein kinases and phosphatases, which catalyze phosphorylation and dephosphorylation respectively, are responsible for switching between different pathways of cell division, development, or differentiation in response to hormones or growth factors. This book provides a comprehensive description of current methods for studying protein phosphorylation and the protein kinases and phosphatases which catalyze it. It includes detailed protocols for studying phosphorylation in intact cells, approaches using enzyme inhibitors, purification of serine/threonine-specific protein kinases/phosphatases, analysis of kinase/phosphatase specificity, and cloning relevant cDNAs. Protein Phosphorylation: A Practical Approach will be of great value to all researchers in the fields of intracellular and intercellular signalling, including biochemists, molecular biologists and pharmacologists.
	Protein Phosphorylation in Aging and Age-Related Disease (Advances in Cell Aging and Gerontology Series, 16) publisher: Jai Pr, published: 2004-03 ASIN: 0444515836 EAN: 9780444515834 sales rank: 5648670 It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Collectively the articles in this volume of ACAG will provide graduate students, postdocs and e
	Protein Phosphorylation/Vol 8 Books A and B (CSH Conferences on Cell Proliferation) (Cold Spring Harbor Conferences on Cell Proliferation Series) by: Ora M. Rosen publisher: Cold Spring Harbor Laboratory Pr, published: 1981-08-01 ASIN: 0879691409 EAN: 9780879691400
	The Great Brain Debate: Nature or Nurture? (Science Essentials (Princeton Paperback)) by: John E. Dowling publisher: Princeton University Press, published: 2007-07-30 ASIN: 0691133107 EAN: 9780691133102 sales rank: 571552 Whether our personality, intelligence, and behavior are more likely to be shaped by our environment or our genetic coding is not simply an idle question for today's researchers. There are tremendous consequences to understanding the crucial role that environment and genes each play. How we raise and educate our children, how we treat various mental diseases or conditions, how we care for our elderly--these are just some of the issues that can be informed by a better understanding of brain development. In The Great Brain Debate, the eminent neuroscience researcher John Dowling looks at these and other important issues. The work that is being done on the connection between the brain and vision, as well as the ways in which our brains help us learn new languages, are particularly revealing. From this groundbreaking new research, Dowling explains startling new insights into how the brain functions and how it can (or cannot) be molded and changed. By studying the brain across the spectrum of our lives, from infancy through adulthood and into old age, Dowling shows the ways in which both nature and nurture play key roles over the course of a human lifetime.
	Post-translational Modification of Protein Biopharmaceuticals publisher: Wiley-VCH, published: 2009-06-16 ASIN: 3527320741 EAN: 9783527320745 sales rank: 862871 From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering. This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals.

Page: 1 2 > 875