receptor-method books

Related books on 'receptor-method'

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Nuclear Receptors, Volume 364 (Methods in Enzymology)

publisher: Academic Press, published: 2003-11-24
ASIN: 0121822672
EAN: 9780121822675
sales rank: 330134
Nuclear Receptors are inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences.

*Analysis of Nuclear Receptor Ligands
*Structure/Function Analysis of Nuclear Receptors
*Analysis of Nuclear Receptor Co-Factors and Chromatin Remodeling

Cell Surface Receptors: A Short Course on Theory and Methods

by: Lee E. Limbird
publisher: Springer, published: 2004-11-12
ASIN: 0387230696
EAN: 9780387230696
sales rank: 1084568
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.

Visualization of Receptors In Situ: Applications of Radioligand Binding (Methods in Visualization)

by: Emmanuel Moyse
publisher: CRC Press, published: 2000-11-30
ASIN: 0849300428
EAN: 9780849300424
sales rank: 1879654
Radioligand binding in situ is the most sensitive method for detecting available receptors; the success and reliability of this approach are determined by a number of technical requirements and constraints. Based on the authors' fifteen years of experience in the field, Visualization of Receptors In Situ: Applications of Radioligand Binding explicitly details these procedures - often not encountered in the original research papers - helping the reader overcome the challenges associated with this powerful technique.

Signaling by Toll-Like Receptors (Methods in Signal Transduction Series)

publisher: CRC Press, published: 2008-06-20
ASIN: 1420043188
EAN: 9781420043181
sales rank: 2169681
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.

G Protein-Coupled Receptors (Methods in Signal Transduction Series)

publisher: CRC Press, published: 1999-09-24
ASIN: 0849333849
EAN: 9780849333842
sales rank: 2868358
Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction.
G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors.
This volume is useful at both the university and industrial levels, and is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

The Nuclear Receptor Superfamily: Methods and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-19
ASIN: 1617379131
EAN: 9781617379130
sales rank: 3090669
Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.

Toll-Like Receptors: Methods and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2009-04-01
ASIN: 193411572X
EAN: 9781934115725
sales rank: 3438011
In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories. In Toll-Like Receptors: Methods and Protocols, experts in the field contribute techniques currently used to study TLRs, their downstream signalling pathways, and their role in the pathogenesis of disease, with sections examining TLR expression and the application of genetic techniques and microarray analysis to TLR research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections highlighting tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Toll-Like Receptors: Methods and Protocols provides an ideal manual for a wide range of biologists and medical researchers studying these vital components of the immune system.

Receptor Research Methods

by: GREENSTEIN
publisher: Taylor & Francis, published: 1995-08-01
ASIN: 3718656701
EAN: 9783718656707
sales rank: 6524043

Receptor Research Methods has been designed with the "systems" worker in mind. The emphasis is on how receptors can be used to tackle a problem, rather than studying the receptor per se.
This book describes and evaluates the techniques used in receptor research. The range and scope of receptor studies becomes apparent through giving examples of the use of these techniques in overcoming problems of receptor identification in the brain and other tissues. Measurement of receptor action is done directly and also indirectly, through cellular expression of receptor activation by appropriate ligands. The role of the receptor in physiological and pathological states is also discussed in the book.

Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry)

publisher: Wiley-VCH, published: 2006-04-03
ASIN: 3527312846
EAN: 9783527312849
sales rank: 3311402
G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design.
Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs.
Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

Steroid Receptor Methods: Protocols and Assays (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-10
ASIN: 161737170X
EAN: 9781617371707
sales rank: 6756562
A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.

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	Nuclear Receptors, Volume 364 (Methods in Enzymology) publisher: Academic Press, published: 2003-11-24 ASIN: 0121822672 EAN: 9780121822675 sales rank: 330134 Nuclear Receptors are inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences. Analysis of Nuclear Receptor Ligands Structure/Function Analysis of Nuclear Receptors *Analysis of Nuclear Receptor Co-Factors and Chromatin Remodeling
	Cell Surface Receptors: A Short Course on Theory and Methods by: Lee E. Limbird publisher: Springer, published: 2004-11-12 ASIN: 0387230696 EAN: 9780387230696 sales rank: 1084568 Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.
	Visualization of Receptors In Situ: Applications of Radioligand Binding (Methods in Visualization) by: Emmanuel Moyse publisher: CRC Press, published: 2000-11-30 ASIN: 0849300428 EAN: 9780849300424 sales rank: 1879654 Radioligand binding in situ is the most sensitive method for detecting available receptors; the success and reliability of this approach are determined by a number of technical requirements and constraints. Based on the authors' fifteen years of experience in the field, Visualization of Receptors In Situ: Applications of Radioligand Binding explicitly details these procedures - often not encountered in the original research papers - helping the reader overcome the challenges associated with this powerful technique.
	Signaling by Toll-Like Receptors (Methods in Signal Transduction Series) publisher: CRC Press, published: 2008-06-20 ASIN: 1420043188 EAN: 9781420043181 sales rank: 2169681 The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
	G Protein-Coupled Receptors (Methods in Signal Transduction Series) publisher: CRC Press, published: 1999-09-24 ASIN: 0849333849 EAN: 9780849333842 sales rank: 2868358 Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors. This volume is useful at both the university and industrial levels, and is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.
	The Nuclear Receptor Superfamily: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-19 ASIN: 1617379131 EAN: 9781617379130 sales rank: 3090669 Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.
	Toll-Like Receptors: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2009-04-01 ASIN: 193411572X EAN: 9781934115725 sales rank: 3438011 In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories. In Toll-Like Receptors: Methods and Protocols, experts in the field contribute techniques currently used to study TLRs, their downstream signalling pathways, and their role in the pathogenesis of disease, with sections examining TLR expression and the application of genetic techniques and microarray analysis to TLR research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections highlighting tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Toll-Like Receptors: Methods and Protocols provides an ideal manual for a wide range of biologists and medical researchers studying these vital components of the immune system.
	Receptor Research Methods by: GREENSTEIN publisher: Taylor & Francis, published: 1995-08-01 ASIN: 3718656701 EAN: 9783718656707 sales rank: 6524043 Receptor Research Methods has been designed with the "systems" worker in mind. The emphasis is on how receptors can be used to tackle a problem, rather than studying the receptor per se. This book describes and evaluates the techniques used in receptor research. The range and scope of receptor studies becomes apparent through giving examples of the use of these techniques in overcoming problems of receptor identification in the brain and other tissues. Measurement of receptor action is done directly and also indirectly, through cellular expression of receptor activation by appropriate ligands. The role of the receptor in physiological and pathological states is also discussed in the book.
	Ligand Design for G Protein-coupled Receptors (Methods and Principles in Medicinal Chemistry) publisher: Wiley-VCH, published: 2006-04-03 ASIN: 3527312846 EAN: 9783527312849 sales rank: 3311402 G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs. Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.
	Steroid Receptor Methods: Protocols and Assays (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-10 ASIN: 161737170X EAN: 9781617371707 sales rank: 6756562 A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.