Related books on 'rna-interference'
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publisher: Wiley, published: 2011-02-15 ASIN: 0471771511 EAN: 9780471771517 sales rank: 1204950 RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects. |
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by: Donald C. Rio publisher: Cold Spring Harbor Laboratory Press, published: 2010-11-29 ASIN: 0879698918 EAN: 9780879698911 sales rank: 393739 So much has been learned about RNA in the past ten years that the ability to purify, analyze, and manipulate RNA molecules is now essential in all kinds of bioscience. Initiating RNA research can be intimidating but the new book RNA: A Laboratory Manual provides a broad range of up-to-date techniques presented in a functional framework, so that any investigator can confidently handle RNA and carry out meaningful experiments, from the most basic to the highly sophisticated. Originating in three of the field's most prominent laboratories, this manual provides the necessary background and strategies for approaching any RNA investigation, as well as detailed protocols and extensive tips and troubleshooting information. It is required reading for every research laboratory in the life sciences. |
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publisher: Caister Academic Press, published: 2010-01-01 ASIN: 1904455565 EAN: 9781904455561 sales rank: 2160322 Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets, such as the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms. Other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, as well as describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV, and respiratory viruses. The book also outlines potential new avenues for research. RNA Interference and Viruses is essential reading for researchers involved in RNAi or antiviral research and is a recommended text for all virology laboratories. |
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publisher: Cambridge University Press, published: 2005-01-17 ASIN: 0521836778 EAN: 9780521836777 sales rank: 913836 RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this 2005 overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference. |
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by: Haig H. Kazazian publisher: FT Press, published: 2011-03-31 ASIN: 0137070624 EAN: 9780137070626 sales rank: 1110184 This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field.
Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding. |
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publisher: Humana Press, published: 2010-11-10 ASIN: 1617374458 EAN: 9781617374456 sales rank: 6882922 A comprehensive collection of cutting-edge methods for elucidating the function of new genes and altering gene expression. These readily reproducible techniques can be used either in transient and stable gene splicing applied to worms, flies, trypanosomes, mammals, and plants, or in studying RNA editing mechanisms in a wide range of organisms, including systems that involve the conversion of one base to another and insertion/deletion editing. Topics of interest include stable and transient RNA interference, gene silencing, RNA editing, bioinformatics, small noncoding RNAs, and RNomics. Special attention is given to methods for the identification and characterization of small RNAs involved in RNA interference or modification. |
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by: John F. Atkins publisher: Cold Spring Harbor Laboratory Press, published: 2010-09-24 ASIN: 0879699469 EAN: 9780879699468 sales rank: 688945 Once thought to be just a messenger that allows genetic information encoded in DNA to direct the formation of proteins, RNA (ribonucleic acid) is now known to be a highly versatile molecule that has multiple roles in cells. It can function as an enzyme, scaffold various subcellular structures, and regulate gene expression through a variety of mechanisms, as well as act as a key component of the protein synthesis and splicing machinery. Perhaps most interestingly, increasing evidence indicates that RNA preceded DNA as the hereditary material and played a crucial role in the early evolution of life on Earth. This volume reviews our understanding of two RNA worlds: the primordial RNA world before DNA, in which RNA was both information store and biocatalyst; and the contemporary RNA world, in which mRNA, tRNA, rRNA, siRNA, miRNA, and a host of other RNAs operate. The early chapters of the book analyze the role of RNA in the first life forms and the appearance of cells. Subsequent chapters examine riboswitches and ribozymes, establishing what the RNA molecule is capable of alone. The book goes on to discuss the evolution of ribosomes and the functions of RNPs, before reviewing the recent work that has revolutionized our understanding of gene regulation by non-coding RNAs, including miRNAs and siRNAs. Also covered are viral RNAs, telomerase RNA, and tools for scientists who work on RNA. The book is thus essential reading for all molecular biologists and biochemists, as well as chemists interested in RNA technology, information storage, or enzyme catalysis. |
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publisher: Humana Press, published: 2010-03-18 ASIN: 1607615878 EAN: 9781607615873 sales rank: 3243907 From the early days when RNA interference was a strange artifact in worms to the 2006 Noble Prize received by Fire and Mello and the current clinical trials, the field of RNA interference has grown at a breakneck pace. In RNA Interference: From Biology to Clinical Applications, expert contributors provide an overview of the most current science and protocols that span the biological disciplines from detailed nucleic acid chemistry, to pharmacology, to the manipulation of signal transduction pathways. Divided into three distinct sections, this volume delves into the physiology of RNA interference, RNA interference in the laboratory and siRNA delivery, and preclinical and clinical issues associated with the use of RNAi-inducing agents as drugs in order to stimulate new questions and offer the tools necessary to start addressing those questions. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and inspiring, RNA Interference: From Biology to Clinical Applications aims to promote and motivate innovation by reviewing what has been done, providing details of how it has been done, and encouraging speculation on what the future may hold. |
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by: Ute Schepers publisher: Wiley-VCH, published: 2005-01-31 ASIN: 3527310207 EAN: 9783527310203 sales rank: 2827986 This hands-on guide to RNA interference brings the power of targeted gene silencing to any laboratory with the basic equipment for handling nucleic acids. In easy-to-follow, step-by-step protocols you will learn:
All the protocols have been thoroughly tested in the author's own laboratory, and she provides examples of successful experiments and troubleshooting hints to help in establishing your own successful RNAi experiments. Also includes a list of suppliers for RNAi reagents and equipment as well as a glossary of terms. |
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by: Moyra Smith publisher: FT Press, published: 2011-06-19 ASIN: 0132168146 EAN: 9780132168144 sales rank: 562560 Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome.
This book addresses into a wide spectrum of topics associated with human genetics and genomics, including:
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