rna-polymerase books

Related books on 'rna-polymerase'

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RNA: Life's Indispensable Molecule

by: James E. Darnell
publisher: Cold Spring Harbor, published: 2011-07-21
ASIN: 1936113198
EAN: 9781936113194
sales rank: 34781
In RNA: Life's Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA, how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.

RNA Polymerases as Molecular Motors (RSC Biomolecular Sciences)

by: Royal Society of Chemistry
publisher: Royal Society of Chemistry, published: 2009-03-10
ASIN: 0854041346
EAN: 9780854041343
sales rank: 1119014

The cell can be viewed as a 'collection of protein machines' and understanding these molecular machines requires sophisticated cooperation between cell biologists, geneticists, enzymologists, crystallographers, chemists and physicists. To observe these machines in action, researchers have developed entirely new methodologies for the detection and the nanomanipulation of single molecules. This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerase. The book concentrates on RNA polymerases because they play a central role among all the other machines operating in the cell and are the target of a wide range of regulatory mechanisms. They have also been the subject of spectacular advances in their structural understanding in recent years, as testified by the attribution of the Nobel prize in chemistry in 2006 to Roger Kornberg. The book focuses on two aspects of the transcription cycle that have been more intensively studied thanks to this increased scientific cooperation - the recognition of the promoter by the enzyme, and the achievement of consecutive translocation steps during elongation of the RNA product. Each of these two topics is introduced by an overview, and is then presented by worldwide experts in the field, taking the viewpoint of their speciality. The overview chapters focus on the mechanism-structure interface and the structure-machine interface while the individual chapters within each section concentrate more specifically on particular processes-kinetic analysis, single-molecule spectroscopy, and termination of transcription, amongst others. Specific attention has been paid to the newcomers in the field, with careful descriptions of new emerging techniques and the constitution of an atlas of three-dimensional pictures of the enzymes involved. For more than thirty years, the study of RNA polymerases has benefited from intense cooperation between the scientific partners involved in the various fields listed above. It is hoped that a collection of essays from outstanding scientists on this subject will catalyse the convergence of scientific efforts in this field, as well as contribute to better teaching at advanced levels in Universities.

RNA: A Laboratory Manual

by: Donald C. Rio
publisher: Cold Spring Harbor Laboratory Press, published: 2010-11-29
ASIN: 0879698918
EAN: 9780879698911
sales rank: 393739
So much has been learned about RNA in the past ten years that the ability to purify, analyze, and manipulate RNA molecules is now essential in all kinds of bioscience. Initiating RNA research can be intimidating but the new book RNA: A Laboratory Manual provides a broad range of up-to-date techniques presented in a functional framework, so that any investigator can confidently handle RNA and carry out meaningful experiments, from the most basic to the highly sophisticated. Originating in three of the field's most prominent laboratories, this manual provides the necessary background and strategies for approaching any RNA investigation, as well as detailed protocols and extensive tips and troubleshooting information. It is required reading for every research laboratory in the life sciences.

Mobile DNA: Finding Treasure in Junk (FT Press Science)

by: Haig H. Kazazian
publisher: FT Press, published: 2011-03-31
ASIN: 0137070624
EAN: 9780137070626
sales rank: 1110184

This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field.

Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding.

Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility (FT Press Science)

by: Moyra Smith
publisher: FT Press, published: 2011-06-19
ASIN: 0132168146
EAN: 9780132168144
sales rank: 562560

Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome.

This book addresses into a wide spectrum of topics associated with human genetics and genomics, including:

Human origins; migrations and human population diversity gained though genomic analyses.
The complexities of psychiatric diseases that are influenced by genetics.
The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS.
Key aspects of protein misfolding.
Gene-environment interactions in DNA damage and repair and DNA instability.
Micro RNAs and mRNA translation.
Epigenetics.

New functions for old enzymes in cancer.

Principles of Evolutionary Medicine (Oxford Biology)

by: Peter Gluckman
publisher: Oxford University Press, USA, published: 2009-09-14
ASIN: 0199236399
EAN: 9780199236398
sales rank: 185096
Evolutionary science is critical to an understanding of integrated human biology and is increasingly recognized as a core underpinning discipline by medical and public health professionals. Advances in the fields of genomics, epigenetics, developmental biology and epidemiology have led to the growing realization that incorporating evolutionary thinking is essential for medicine to achieve its full potential. This is the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilize evolutionary biology. It is written in a style which is accessible to a broad range of readers, whether or not they have had formal exposure to evolutionary science.

Principles of Evolutionary Medicine is divided into three sections: the first provides a systematic approach to the principles of evolutionary biology as they apply to human health and disease, using examples specifically relevant to medicine. It incorporates chapters on evolutionary processes, molecular evolution, the evolution of humans, life history theory, and evolutionary-developmental biology. The second part illustrates the application of these principles to our understanding of nutrition and metabolism, reproduction, combatting infectious disease and stress, and human behaviour. The final section provides a general framework to show in practical terms how the principles of evolutionary medicine can be applied in medical practice and public health.

This novel textbook provides the necessary toolkit for doctors and other health professionals, medical students and biomedical scientists, as well as anthropologists interested in human health, to gain a better understanding of the evolutionary processes underlying human health and disease.

The Evolution and Emergence of RNA Viruses (Oxford Series in Ecology and Evolution)

by: Edward C. Holmes
publisher: Oxford University Press, USA, published: 2009-08-31
ASIN: 0199211132
EAN: 9780199211135
sales rank: 488426
RNA viruses provide unique insights into the patterns and processes of evolutionary change in real time. The study of viral evolution is especially topical given the growing awareness that emerging and re-emerging diseases (most of which are caused by RNA viruses) represent a major threat to public health. However, while the study of viral evolution has developed rapidly in the last 30 years, relatively little attention has been directed toward linking work on the mechanisms of viral evolution within cells or individual hosts, to the epidemiological outcomes of these processes. This novel book fills this gap by considering the patterns and processes of viral evolution across their entire range of spatial and temporal scales.

The Evolution and Emergence of RNA Viruses provides a comprehensive overview of RNA virus evolution. This is the first book to link mechanisms of viral evolution to epidemiological outcomes, incorporating case studies in RNA virus emergence and evolution using topical examples such as influenza, HIV, dengue fever, and rabies. It reveals the underlying evolutionary processes by which emerging viruses cross species boundaries and spread in new hosts.

RNA Polymerase and Associated Factors, Part C, Volume 370 (Methods in Enzymology)

publisher: Academic Press, published: 2003-12-30
ASIN: 0121822737
EAN: 9780121822736
sales rank: 3762210
RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein.

* Construction and purification of RNA polymerases
* DNA microarrays and bacterial gene expression
* Functional analysis of transcription factors

Methods in Enzymology, Volume 371: RNA Polymerase and Associated Factors, Part D

publisher: Academic Press, published: 2003-12-30
ASIN: 0121822745
EAN: 9780121822743
sales rank: 3942386
RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein.

* Models and methods for studying polymerase translocation
* Assay for movements of RNA polymerase along DNA
* Engineering of elongation complexes of bacterial and yeast RNA polymerases

Transcription of Ribosomal RNA Genes by Eukaryotic RNA Polymerase I (Biotechnology Intelligence Unit)

publisher: Springer, published: 1998-11-13
ASIN: 3540643656
EAN: 9783540643654
sales rank: 8875242
The mechanism by which ribosomal RNA is synthesized has been a topic of intensive research for nearly 30 years. In 1981 the first in vitro transcription system for ribosomal RNA from a eukaryote - mouse ascites cells - was reported, followed rapidly by similar systems in a variety of other eukaryotes, all revealed by a relatively small number of research groups. This monograph is the first to bring together the results and opinions of all these groups. Though it unavoidably emphasizes the common features of ribosomal RNA transcription between species, the species specificity of the process and nucleolar dominance and its possible mechanism(s) are also discussed.

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	RNA: Life's Indispensable Molecule by: James E. Darnell publisher: Cold Spring Harbor, published: 2011-07-21 ASIN: 1936113198 EAN: 9781936113194 sales rank: 34781 In RNA: Life's Indispensable Molecule, Jim Darnell provides a comprehensive and captivating account of RNA research, illuminated by his own life-long and celebrated engagement in the field. Darnell describes how scientists unraveled fundamental questions about the biochemical and genetic importance of RNA, how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, and how RNA molecules likely initiated life on Earth. With a scope extending from the early 20th century to the present day, and with the clarity expected from an accomplished textbook author, he conveys the intellectual context in which these questions first arose and explains how the key experiments were structured and answers obtained. The book is geared towards scientists from the graduate level on up, and will particularly appeal to active investigators in RNA biology, educators of molecular biology and biochemistry, and science historians.
	RNA Polymerases as Molecular Motors (RSC Biomolecular Sciences) by: Royal Society of Chemistry publisher: Royal Society of Chemistry, published: 2009-03-10 ASIN: 0854041346 EAN: 9780854041343 sales rank: 1119014 The cell can be viewed as a 'collection of protein machines' and understanding these molecular machines requires sophisticated cooperation between cell biologists, geneticists, enzymologists, crystallographers, chemists and physicists. To observe these machines in action, researchers have developed entirely new methodologies for the detection and the nanomanipulation of single molecules. This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerase. The book concentrates on RNA polymerases because they play a central role among all the other machines operating in the cell and are the target of a wide range of regulatory mechanisms. They have also been the subject of spectacular advances in their structural understanding in recent years, as testified by the attribution of the Nobel prize in chemistry in 2006 to Roger Kornberg. The book focuses on two aspects of the transcription cycle that have been more intensively studied thanks to this increased scientific cooperation - the recognition of the promoter by the enzyme, and the achievement of consecutive translocation steps during elongation of the RNA product. Each of these two topics is introduced by an overview, and is then presented by worldwide experts in the field, taking the viewpoint of their speciality. The overview chapters focus on the mechanism-structure interface and the structure-machine interface while the individual chapters within each section concentrate more specifically on particular processes-kinetic analysis, single-molecule spectroscopy, and termination of transcription, amongst others. Specific attention has been paid to the newcomers in the field, with careful descriptions of new emerging techniques and the constitution of an atlas of three-dimensional pictures of the enzymes involved. For more than thirty years, the study of RNA polymerases has benefited from intense cooperation between the scientific partners involved in the various fields listed above. It is hoped that a collection of essays from outstanding scientists on this subject will catalyse the convergence of scientific efforts in this field, as well as contribute to better teaching at advanced levels in Universities.
	RNA: A Laboratory Manual by: Donald C. Rio publisher: Cold Spring Harbor Laboratory Press, published: 2010-11-29 ASIN: 0879698918 EAN: 9780879698911 sales rank: 393739 So much has been learned about RNA in the past ten years that the ability to purify, analyze, and manipulate RNA molecules is now essential in all kinds of bioscience. Initiating RNA research can be intimidating but the new book RNA: A Laboratory Manual provides a broad range of up-to-date techniques presented in a functional framework, so that any investigator can confidently handle RNA and carry out meaningful experiments, from the most basic to the highly sophisticated. Originating in three of the field's most prominent laboratories, this manual provides the necessary background and strategies for approaching any RNA investigation, as well as detailed protocols and extensive tips and troubleshooting information. It is required reading for every research laboratory in the life sciences.
	Mobile DNA: Finding Treasure in Junk (FT Press Science) by: Haig H. Kazazian publisher: FT Press, published: 2011-03-31 ASIN: 0137070624 EAN: 9780137070626 sales rank: 1110184 This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field. Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding.
	Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility (FT Press Science) by: Moyra Smith publisher: FT Press, published: 2011-06-19 ASIN: 0132168146 EAN: 9780132168144 sales rank: 562560 Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome. This book addresses into a wide spectrum of topics associated with human genetics and genomics, including: Human origins; migrations and human population diversity gained though genomic analyses. The complexities of psychiatric diseases that are influenced by genetics. The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS. Key aspects of protein misfolding. Gene-environment interactions in DNA damage and repair and DNA instability. Micro RNAs and mRNA translation. Epigenetics. New functions for old enzymes in cancer.
	Principles of Evolutionary Medicine (Oxford Biology) by: Peter Gluckman publisher: Oxford University Press, USA, published: 2009-09-14 ASIN: 0199236399 EAN: 9780199236398 sales rank: 185096 Evolutionary science is critical to an understanding of integrated human biology and is increasingly recognized as a core underpinning discipline by medical and public health professionals. Advances in the fields of genomics, epigenetics, developmental biology and epidemiology have led to the growing realization that incorporating evolutionary thinking is essential for medicine to achieve its full potential. This is the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilize evolutionary biology. It is written in a style which is accessible to a broad range of readers, whether or not they have had formal exposure to evolutionary science. Principles of Evolutionary Medicine is divided into three sections: the first provides a systematic approach to the principles of evolutionary biology as they apply to human health and disease, using examples specifically relevant to medicine. It incorporates chapters on evolutionary processes, molecular evolution, the evolution of humans, life history theory, and evolutionary-developmental biology. The second part illustrates the application of these principles to our understanding of nutrition and metabolism, reproduction, combatting infectious disease and stress, and human behaviour. The final section provides a general framework to show in practical terms how the principles of evolutionary medicine can be applied in medical practice and public health. This novel textbook provides the necessary toolkit for doctors and other health professionals, medical students and biomedical scientists, as well as anthropologists interested in human health, to gain a better understanding of the evolutionary processes underlying human health and disease.
	The Evolution and Emergence of RNA Viruses (Oxford Series in Ecology and Evolution) by: Edward C. Holmes publisher: Oxford University Press, USA, published: 2009-08-31 ASIN: 0199211132 EAN: 9780199211135 sales rank: 488426 RNA viruses provide unique insights into the patterns and processes of evolutionary change in real time. The study of viral evolution is especially topical given the growing awareness that emerging and re-emerging diseases (most of which are caused by RNA viruses) represent a major threat to public health. However, while the study of viral evolution has developed rapidly in the last 30 years, relatively little attention has been directed toward linking work on the mechanisms of viral evolution within cells or individual hosts, to the epidemiological outcomes of these processes. This novel book fills this gap by considering the patterns and processes of viral evolution across their entire range of spatial and temporal scales. The Evolution and Emergence of RNA Viruses provides a comprehensive overview of RNA virus evolution. This is the first book to link mechanisms of viral evolution to epidemiological outcomes, incorporating case studies in RNA virus emergence and evolution using topical examples such as influenza, HIV, dengue fever, and rabies. It reveals the underlying evolutionary processes by which emerging viruses cross species boundaries and spread in new hosts.
	RNA Polymerase and Associated Factors, Part C, Volume 370 (Methods in Enzymology) publisher: Academic Press, published: 2003-12-30 ASIN: 0121822737 EAN: 9780121822736 sales rank: 3762210 RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein. * Construction and purification of RNA polymerases * DNA microarrays and bacterial gene expression * Functional analysis of transcription factors
	Methods in Enzymology, Volume 371: RNA Polymerase and Associated Factors, Part D publisher: Academic Press, published: 2003-12-30 ASIN: 0121822745 EAN: 9780121822743 sales rank: 3942386 RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein. * Models and methods for studying polymerase translocation * Assay for movements of RNA polymerase along DNA * Engineering of elongation complexes of bacterial and yeast RNA polymerases
	Transcription of Ribosomal RNA Genes by Eukaryotic RNA Polymerase I (Biotechnology Intelligence Unit) publisher: Springer, published: 1998-11-13 ASIN: 3540643656 EAN: 9783540643654 sales rank: 8875242 The mechanism by which ribosomal RNA is synthesized has been a topic of intensive research for nearly 30 years. In 1981 the first in vitro transcription system for ribosomal RNA from a eukaryote - mouse ascites cells - was reported, followed rapidly by similar systems in a variety of other eukaryotes, all revealed by a relatively small number of research groups. This monograph is the first to bring together the results and opinions of all these groups. Though it unavoidably emphasizes the common features of ribosomal RNA transcription between species, the species specificity of the process and nucleolar dominance and its possible mechanism(s) are also discussed.