tissue-microarray books

Related books on 'tissue-microarray'

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Advances in cancer tissue microarray technology: Towards improved understanding and diagnostics [An article from: Analytica Chimica Acta]

by: W. Chen
publisher: Elsevier, published: 2006-03-30
ASIN: B000PBZYXC
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Over the past few years, tissue microarray (TMA) technology has been established as a standard method for assessing the expression of proteins or genes across large sets of tissue specimens. It is being adopted increasingly among leading research institutions around the world and utilized in cancer research in parallel with the cDNA microarray technology. This article summarizes various aspects of cancer understanding and diagnostics in which TMA has had great impact. Although tremendous advances continue to be made to facilitate imaging and archiving of TMA specimens, automatic evaluation and quantitative analysis of TMA still remains an important challenge for modern investigators.

Biopsy Interpretation of Soft Tissue Tumors (Biopsy Interpretation Series)

by: Cyril Fisher
publisher: Lippincott Williams & Wilkins, published: 2010-11-22
ASIN: 0781795591
EAN: 9780781795593
sales rank: 408358
Biopsy Interpretation of Soft Tissue Tumors is a practical guide and bench reference for surgical pathologists for the interpretation of soft tissue biopsies, including open and percutaneous core needle biopsies. Each chapter guides readers in a logical way, with the key differential diagnostic features of specific tumors detailed within each category, using morphologic, immunohistochemical, ultrastructural, and genetic data. This parallels and complements the normal diagnostic process. In addition to color photomicrographs the book includes numerous tables for differential diagnosis of specific morphologic features and use of immunohistochemical panels. Relevant clinical and management points impacted by the pathologic diagnosis are included.

Tissue Engineering: From Lab to Clinic

publisher: Springer, published: 2011-03-10
ASIN: 3642028233
EAN: 9783642028236
sales rank: 986538
Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This abundantly illustrated and well-structured guide serves as a reference for all clinicians and researchers dealing with tissue engineering issues in their daily practice.

Principles of Translational Science in Medicine: From Bench to Bedside

publisher: Cambridge University Press, published: 2009-12-21
ASIN: 0521888697
EAN: 9780521888691
sales rank: 618822
Despite advancements in the cloning of the total human genome, biomedical innovations at the patient level are becoming rare events. However, translational medicine is a burgeoning science that shows the potential to reverse the trend. This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations, including target risk assessment, biomarker evaluation, and predictivity grading for both efficacy and toxicity; early human trial designs that are adequate to guide stop or go decisions on the grounds of biomarker panels; and biostatistical methods to analyze multiple readout situations and quantify risk projections. The book provides guidance to design smart profiling strategies for new approaches aimed at cutting timelines and concentrating on the comparison of quality issues of early developmental processes for pharmaceutical and biotechnology research. By furthering the substantiation of translational medicine, creating awareness about its potential to promote innovations into clinical practice, and examining the terminology surrounding current biotechnologies, this book hopes to create a dialogue about translational science and what this will mean for patient care in the near future.

Cells, Tissues, and Disease: Principles of General Pathology (Majno, Cells, Tissues, and Disease)

by: Guido Majno
publisher: Oxford University Press, USA, published: 2004-08-26
ASIN: 0195140907
EAN: 9780195140903
sales rank: 1278498
This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.

Microarray Analysis

by: Mark Schena
publisher: Wiley-Liss, published: 2002-11-11
ASIN: 0471414433
EAN: 9780471414438
sales rank: 1769228
This authoritative text begins with an introduction to basic microarray technology. The author then provides clear explanations of the conceptual and theoretical basis of this technology, followed by thorough and multi-disciplinary coverage of modern and emerging applications. The coverageincludes chapters on microarray informatics, gene expression profiling, genetic diagnostics, and novel microarray technologies.

Microarrays and Microplates: Applications in Biomedical Sciences (Advanced Methods)

publisher: Garland Science, published: 2003-06-25
ASIN: 185996074X
EAN: 9781859960745
sales rank: 6490771
The 'Advanced Methods' series is intended for advanced undergraduates, postgraduates and established research scientists. Titles in the series are designed to cover current important areas of research in life sciences, and include both theoretical background and detailed protocols. The aim is to give researchers sufficient theory, supported by references, to take the given protocols and adapt them to their particular experimental systems.
Microarrays and Microplates title looks at the new microarray and microplate-based technologies which facilitate large-scale analysis of DNA sequence variants, mRNA molecules and proteins. The book provides a review of the various methodologies being used to identify genetic variants and gene regulation and guides readers through both the application of these methodologies and experimental procedures.

Cytohistology: Essential and Basic Concepts (Cytohistology of Small Tissue Samples)

publisher: Cambridge University Press, published: 2011-03-28
ASIN: 052188358X
EAN: 9780521883580
sales rank: 609182
This book represents the essentials of diagnostic cytopathology. Clinical research has confirmed the efficacy of the cytologic method of disease diagnosis and it is now considered the definitive method for identifying a wide array of malignancies. Cytohistology: Essentials and Basic Concepts comprehensively covers all the morphologic variations and landmarks in cells that can potentially signal disease. Morphologies in cancer are the primary focus but all potential changes in infectious and inflammatory disorders are also covered in detail. There is a separate section on molecular and other ancillary diagnostic techniques in cytopathology. Conceptual drawings presented in a pansystemic approach and incorporating state-of-the-art techniques show basic cytomorphologic features essential for interpretation of cytopathology specimens. Diagnostic pitfalls and challenging intellectual nuggets are also presented. A supplementary CD with images in a downloadable format is included.

Handbook of Practical Immunohistochemistry: Frequently Asked Questions

publisher: Springer, published: 2011-07-01
ASIN: 144198061X
EAN: 9781441980618
sales rank: 215608
In a conceptually current, quick-reference, Question & Answer format, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions provides standardization of the immunostaining process for each antibody and for each staining panel. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 5,000 tumors to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Chapters are presented in a unique Question and Answer format. One table/IHC panel is provided to address each question. A concise explanatory note follows each table/panel to avoid diagnostic pitfalls. Website links are provided throughout to update the massive information in this field, providing the most current knowledge and the potential for live expert consultation. All chapters are written by nationally/internationally recognized experts in the related area ensuring authority and excellence. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Microarrays Methods and Applications (Nuts & Bolts series)

by: Gary Hardiman PhD
publisher: Dna Press, published: 2003-06
ASIN: 0966402766
EAN: 9780966402766
sales rank: 3285276
The confluence of robotics, biotechnology, computer sciences and the completion of genome sequencing efforts for several organisms have resulted in revolutionary changes in how biomedical research is carried out. In recent years high-density arrays of specified DNA sequences have gained in popularity. Genomics and informatics are playing increasingly important roles as discovery tools in the basic biological sciences, and as diagnostic and rational therapeutic aids in the clinical arena. The genesis of this publication was a microarray workshop organized by Dr. Gary Hardiman and The Department of Bioscience at The University of California San Diego Extension. Gary Hardiman is the Director of BIOGEM (an organized research unit and core facility) specializing in high throughput genomic approaches, including DNA microarray technology and bioinformatics. He also teaches at the University of California San Diego Extension (Bioscience) Drug Discovery and Development Professional Certificate Program. The combination of his experience at a core facility and teaching obligations has contributed to the publication of a book that serves both as a practical laboratory manual and a class reference for teaching microarray technology. The book provides both an introduction and detailed overview of microarray technologies in academic and industrial settings. It examines evolving technology standards for microarray research, explores automation and instrumentation in the array laboratory, and discusses in detail the set up and operation of a microarray core facility.

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	Advances in cancer tissue microarray technology: Towards improved understanding and diagnostics [An article from: Analytica Chimica Acta] by: W. Chen publisher: Elsevier, published: 2006-03-30 ASIN: B000PBZYXC This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Over the past few years, tissue microarray (TMA) technology has been established as a standard method for assessing the expression of proteins or genes across large sets of tissue specimens. It is being adopted increasingly among leading research institutions around the world and utilized in cancer research in parallel with the cDNA microarray technology. This article summarizes various aspects of cancer understanding and diagnostics in which TMA has had great impact. Although tremendous advances continue to be made to facilitate imaging and archiving of TMA specimens, automatic evaluation and quantitative analysis of TMA still remains an important challenge for modern investigators.
	Biopsy Interpretation of Soft Tissue Tumors (Biopsy Interpretation Series) by: Cyril Fisher publisher: Lippincott Williams & Wilkins, published: 2010-11-22 ASIN: 0781795591 EAN: 9780781795593 sales rank: 408358 Biopsy Interpretation of Soft Tissue Tumors is a practical guide and bench reference for surgical pathologists for the interpretation of soft tissue biopsies, including open and percutaneous core needle biopsies. Each chapter guides readers in a logical way, with the key differential diagnostic features of specific tumors detailed within each category, using morphologic, immunohistochemical, ultrastructural, and genetic data. This parallels and complements the normal diagnostic process. In addition to color photomicrographs the book includes numerous tables for differential diagnosis of specific morphologic features and use of immunohistochemical panels. Relevant clinical and management points impacted by the pathologic diagnosis are included.
	Tissue Engineering: From Lab to Clinic publisher: Springer, published: 2011-03-10 ASIN: 3642028233 EAN: 9783642028236 sales rank: 986538 Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This abundantly illustrated and well-structured guide serves as a reference for all clinicians and researchers dealing with tissue engineering issues in their daily practice.
	Principles of Translational Science in Medicine: From Bench to Bedside publisher: Cambridge University Press, published: 2009-12-21 ASIN: 0521888697 EAN: 9780521888691 sales rank: 618822 Despite advancements in the cloning of the total human genome, biomedical innovations at the patient level are becoming rare events. However, translational medicine is a burgeoning science that shows the potential to reverse the trend. This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations, including target risk assessment, biomarker evaluation, and predictivity grading for both efficacy and toxicity; early human trial designs that are adequate to guide stop or go decisions on the grounds of biomarker panels; and biostatistical methods to analyze multiple readout situations and quantify risk projections. The book provides guidance to design smart profiling strategies for new approaches aimed at cutting timelines and concentrating on the comparison of quality issues of early developmental processes for pharmaceutical and biotechnology research. By furthering the substantiation of translational medicine, creating awareness about its potential to promote innovations into clinical practice, and examining the terminology surrounding current biotechnologies, this book hopes to create a dialogue about translational science and what this will mean for patient care in the near future.
	Cells, Tissues, and Disease: Principles of General Pathology (Majno, Cells, Tissues, and Disease) by: Guido Majno publisher: Oxford University Press, USA, published: 2004-08-26 ASIN: 0195140907 EAN: 9780195140903 sales rank: 1278498 This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.
	Microarray Analysis by: Mark Schena publisher: Wiley-Liss, published: 2002-11-11 ASIN: 0471414433 EAN: 9780471414438 sales rank: 1769228 This authoritative text begins with an introduction to basic microarray technology. The author then provides clear explanations of the conceptual and theoretical basis of this technology, followed by thorough and multi-disciplinary coverage of modern and emerging applications. The coverageincludes chapters on microarray informatics, gene expression profiling, genetic diagnostics, and novel microarray technologies.
	Microarrays and Microplates: Applications in Biomedical Sciences (Advanced Methods) publisher: Garland Science, published: 2003-06-25 ASIN: 185996074X EAN: 9781859960745 sales rank: 6490771 The 'Advanced Methods' series is intended for advanced undergraduates, postgraduates and established research scientists. Titles in the series are designed to cover current important areas of research in life sciences, and include both theoretical background and detailed protocols. The aim is to give researchers sufficient theory, supported by references, to take the given protocols and adapt them to their particular experimental systems. Microarrays and Microplates title looks at the new microarray and microplate-based technologies which facilitate large-scale analysis of DNA sequence variants, mRNA molecules and proteins. The book provides a review of the various methodologies being used to identify genetic variants and gene regulation and guides readers through both the application of these methodologies and experimental procedures.
	Cytohistology: Essential and Basic Concepts (Cytohistology of Small Tissue Samples) publisher: Cambridge University Press, published: 2011-03-28 ASIN: 052188358X EAN: 9780521883580 sales rank: 609182 This book represents the essentials of diagnostic cytopathology. Clinical research has confirmed the efficacy of the cytologic method of disease diagnosis and it is now considered the definitive method for identifying a wide array of malignancies. Cytohistology: Essentials and Basic Concepts comprehensively covers all the morphologic variations and landmarks in cells that can potentially signal disease. Morphologies in cancer are the primary focus but all potential changes in infectious and inflammatory disorders are also covered in detail. There is a separate section on molecular and other ancillary diagnostic techniques in cytopathology. Conceptual drawings presented in a pansystemic approach and incorporating state-of-the-art techniques show basic cytomorphologic features essential for interpretation of cytopathology specimens. Diagnostic pitfalls and challenging intellectual nuggets are also presented. A supplementary CD with images in a downloadable format is included.
	Handbook of Practical Immunohistochemistry: Frequently Asked Questions publisher: Springer, published: 2011-07-01 ASIN: 144198061X EAN: 9781441980618 sales rank: 215608 In a conceptually current, quick-reference, Question & Answer format, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions provides standardization of the immunostaining process for each antibody and for each staining panel. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 5,000 tumors to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Chapters are presented in a unique Question and Answer format. One table/IHC panel is provided to address each question. A concise explanatory note follows each table/panel to avoid diagnostic pitfalls. Website links are provided throughout to update the massive information in this field, providing the most current knowledge and the potential for live expert consultation. All chapters are written by nationally/internationally recognized experts in the related area ensuring authority and excellence. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
	Microarrays Methods and Applications (Nuts & Bolts series) by: Gary Hardiman PhD publisher: Dna Press, published: 2003-06 ASIN: 0966402766 EAN: 9780966402766 sales rank: 3285276 The confluence of robotics, biotechnology, computer sciences and the completion of genome sequencing efforts for several organisms have resulted in revolutionary changes in how biomedical research is carried out. In recent years high-density arrays of specified DNA sequences have gained in popularity. Genomics and informatics are playing increasingly important roles as discovery tools in the basic biological sciences, and as diagnostic and rational therapeutic aids in the clinical arena. The genesis of this publication was a microarray workshop organized by Dr. Gary Hardiman and The Department of Bioscience at The University of California San Diego Extension. Gary Hardiman is the Director of BIOGEM (an organized research unit and core facility) specializing in high throughput genomic approaches, including DNA microarray technology and bioinformatics. He also teaches at the University of California San Diego Extension (Bioscience) Drug Discovery and Development Professional Certificate Program. The combination of his experience at a core facility and teaching obligations has contributed to the publication of a book that serves both as a practical laboratory manual and a class reference for teaching microarray technology. The book provides both an introduction and detailed overview of microarray technologies in academic and industrial settings. It examines evolving technology standards for microarray research, explores automation and instrumentation in the array laboratory, and discusses in detail the set up and operation of a microarray core facility.