Related books on 'transcriptional-regulation'
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by: Albert J. Courey publisher: Wiley-Blackwell, published: 2008-04-29 ASIN: 1405103701 EAN: 9781405103701 sales rank: 922623 Mechanisms in Transcriptional Regulation provides a concise discussion of the fundamental concepts in transcription and its regulation.
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by: Michael Carey publisher: Cold Spring Harbor Laboratory Press, published: 2008-12-01 ASIN: 0879697628 EAN: 9780879697624 sales rank: 1504648 Strategies for studying gene regulation mechanisms have changed dramatically over the past several years in light of the emergence of complete genome sequences for many organisms as well as the development of or improvements to technologies such as chromatin immunoprecipitation, RNA interference, microarrays, and proteomics. The first edition of the highly successful Transcriptional Regulation in Eukaryotes, written by Michael Carey and Stephen Smale at UCLA, provided a comprehensive source of strategic, conceptual, and technical information for investigating the complexities of gene regulation at the level of transcription. With the ever-increasing importance of genome data and the appearance of new and better techniques, the second edition of this book has added a third author, Craig Peterson at the University of Massachusetts Medical School. In addition to a new chapter on the in vitro analysis of chromatin templates for DNA-binding studies and transcription, this second edition has been extensively rewritten and updated to discuss new advances in the field and their impact on gene regulation mechanisms. The second edition retains the approach of the first in covering both the conceptual and practical aspects of how to study the regulation of a newly isolated gene and the biochemistry of a new transcription factor. Transcriptional Regulation in Eukaryotes serves as both a powerful textbook and manual for advanced instruction in molecular biology which supplements clearly written text with extensive illustrations puts methods in the context of underlying theory gives expert recommendations on experimental strategies encourages creativity in investigative design explains protocols for essential techniques step by step, with extensive advice on troubleshooting provides the latest methods in use in the field. This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states, providing underlying theory and perspective to the newcomer and the latest techniques to the expert. Related Titles from the Publisher Epigenetics Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual Live Cell Imaging: A Laboratory Manual, 2nd ed. Single-Molecule Techniques: A Laboratory Manual |
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by: Keith N. Frayn publisher: Wiley-Blackwell, published: 2010-03-09 ASIN: 1405183594 EAN: 9781405183598 sales rank: 298473 The important Third Edition of this successful book conveys a modern and integrated picture of metabolism and metabolic regulation. Explaining difficult concepts with unequalled clarity, author Keith Frayn provides the reader with an essential guide to the subject. Covering topics such as energy balance, body weight regulation and how the body copes with extreme situations, this book illustrates how metabolic regulation allows the human body to adapt to many different conditions. Changes throughout the new edition include:
Frayn has written a book which will continue to be an extremely valuable tool for scientists, practitioners and students working and studying across a broad range of allied health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing. |
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publisher: Humana Press, published: 2010-11-19 ASIN: 1617376027 EAN: 9781617376023 sales rank: 1375951 A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice. |
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publisher: Humana Press, published: 2011-11-24 ASIN: 1617793752 EAN: 9781617793752 sales rank: 2724182 Through many recent remarkable developments, perhaps the most significant advancements in the study of transcriptional regulation are the development of genome-wide approaches for measuring gene expression, exemplified by gene chips (chip), and chromatin immunoprecipitation assays (ChIP) for measuring in vivo protein-DNA interactions at any genomic loci. Transcriptional Regulation: Methods and Protocols takes this progress and builds upon it with a collection of key protocols used in expert laboratories around the world. Divided into four convenient sections, this detailed volume explores promoter elements, transcription factors, and preinitiation complex (PIC) assembly, chromatin structure, chromatin modifying complexes, and RNA synthesis and regulation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and accessible, Transcriptional Regulation: Methods and Protocols equally serves senior researchers and scientists experienced in transcriptional regulation as well as graduate students and scientists who wish to study transcriptional regulation for the first time. |
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publisher: Springer, published: 2010-11-04 ASIN: 144194463X EAN: 9781441944634 sales rank: 3852739 Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. This book offers an up-to-date picture of the field. |
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by: Joe Sambrook publisher: Cold Spring Harbor Laboratory Press, published: 2001-01-15 ASIN: 0879695773 EAN: 9780879695774 sales rank: 119867 The first two editions of this manual have been mainstays of molecular biology for nearly twenty years, with an unrivalled reputation for reliability, accuracy, and clarity. In this new edition, authors Joe Sambrook and David Russell have completely updated the book, revising every protocol and adding a mass of new material, to broaden its scope and maintain its unbeatable value for studies in genetics, molecular cell biology, developmental biology, microbiology, neuroscience, and immunology. Handsomely redesigned and presented in new bindings of proven durability, this three-volume work is essential for everyone using todays biomolecular techniques. The opening chapters describe essential techniques, some well-established, some new, that are used every day in the best laboratories for isolating, analyzing and cloning DNA molecules, both large and small. These are followed by chapters on cDNA cloning and exon trapping, amplification of DNA, generation and use of nucleic acid probes, mutagenesis, and DNA sequencing. The concluding chapters deal with methods to screen expression libraries, express cloned genes in both prokaryotes and eukaryotic cells, analyze transcripts and proteins, and detect protein-protein interactions. The Appendix is a compendium of reagents, vectors, media, technical suppliers, kits, electronic resources and other essential information. As in earlier editions, this is the only manual that explains how to achieve success in cloning and provides a wealth of information about why techniques work, how they were first developed, and how they have evolved. |
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by: Gerhard Krauss publisher: Wiley-VCH, published: 2008-04-15 ASIN: 3527313974 EAN: 9783527313976 sales rank: 1005571 This all-new edition of a best-selling text has been thoroughly updated to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity, the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis is made transparent for everyone with a basic knowledge in biochemistry or molecular biology. "Valuable up-to-date information on biochemistry of signal transduction and regulation" (AFS) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research) |
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publisher: Springer, published: 2010-09-01 ASIN: 1441970045 EAN: 9781441970046 sales rank: 4260171 This book aims to bring to the forefront a field that has been developing since the late 1990s called the STAR pathway for Signal Transduction and Activation of RNA. It is a signaling pathway that targets RNA directly; in contrast to the canonical signal—kinase cascade—transcription factor—DNA—RNA. It is proposed to allow quick responses to environment changes such as those necessary in many biological phenomenon such as the nervous system and during development. |
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by: Michael Carey publisher: Cold Spring Harbor Laboratory Press, published: 2002-01 ASIN: 0879696354 EAN: 9780879696351 sales rank: 2642952 In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. "Transcriptional Regulation in Eukaryotes" aims to answer that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. Chapter 1 reviews the state-of-the-art in the RNA polymerase II transcription field; while chapters 2 to 10 are a systematic guide to the investigation of regulatory mechanisms for newly identified genes. Chapters 11 to 15 discuss approaches for synthesizing recombinant transcription factors, analyzing their binding, and deciphering their mode of action. This text reveals not only what to do but why, and how to plan properly for success. This approach should be useful for graduate students, physician-scientists, postdocs, and others entering the field, but is also valuable for established investigators undertaking in-depth studies in specific systems. Supplementing clearly written text with extensive illustrations, this text puts methods in the context of underlying theory and offers expert recommendations on experimental strategies, and encourages creativity in investigative design. Protocols for essential techniques are presented in a step by step format, together with extensive advice on troubleshooting. |