Related books on 'animal-model'

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by: Karen M. Tobias DVM MS DACVS
publisher: Saunders, published: 2011-12-12
ASIN: 1437707467
EAN: 9781437707465
sales rank: 45184

With detailed coverage of surgical procedures, Veterinary Surgery: Small Animal is an authoritative, two-volume reference on the art and science of small animal surgery. Expert contributors discuss surgical principles and procedures for topics ranging from surgical biology and perioperative care, to neurosurgery orthopedic surgery, and soft tissue surgery, always supported by evidence-based research and complete surgical instructions. More procedures are covered with greater detail than in comparable books, and a greater emphasis on pathophysiology shows how it relates to diagnosis, treatment, and overall case management. Experienced Coeditors Karen Tobias and Spencer Johnston provide the definitive reference for veterinary surgery, invaluable preparation for the ACVS and ECVS board examinations.

  • Blend of clinical and basic science information provides the best possible understanding of clinical issues surrounding operative situations.
  • Specific procedures are covered in great detail and are brought to life with full-color drawings and photographs.
  • Highly recognized contributors provide authoritative coverage that is useful for surgical specialists as well as practicing veterinarians who perform surgery or refer cases for surgery.
  • Detailed coverage of small animal surgery provides excellent preparation for the written examination of the American College of Veterinary Surgeons, and the European College of Veterinary Surgeons.
  • Comprehensive coverage includes surgical biology, surgical methods and perioperative care, neurosurgery, and orthopedics in Volume I; soft tissue surgery is covered in Volume II.
  • Coverage of anatomy, physiology, and pathophysiology in chapters on specific organs includes information critical to operative procedures and patient management.
  • In-depth chapters on anesthesia and pain provide indispensable resources for practicing surgeons.
  • Treatment of cancers in small animals is covered in chapters on surgical oncology, tumors of the spine, and musculoskeletal neoplasia.
  • Extensive references to published studies show the factual basis for the material.
  • The companion website includes all of the images in the book for convenient access,  plus references linked to original abstracts on PubMed.

 


publisher: Informa Healthcare, published: 2003-12-29
ASIN: 0849313910
EAN: 9780849313912
sales rank: 2436230

Providing peer-reviewed chapters covering spontaneous and experimental animal models of inflammatory skin diseases, this book is a reference for investigators in the biomedical and pharmaceutical sciences. The author covers general methods of experimental modeling and describes methods of generating experimental animal models. He includes a detailed method of disease induction for each model, presents chapters on comparative histology and immunology, and disseminates information on the potential targets of disease intervention. The book is a guide for choosing the animal models to test on the in vivo level the data that they had derived at the in vitro levels in the laboratory.


by: Charles Knight
publisher: Dover Publications, published: 1959-06-01
ASIN: 048620426X
EAN: 9780486204260
sales rank: 94639
A master of animal portraiture presents an extensive course in creating lifelike drawings of a host of creatures: great apes, tigers, lions, dogs, bears, horses, crocodiles, snakes, fish, and many others. Subjects include animal musculature, bone structure, psychology, movements, habits, and habitats. Suitable for commercial and fine artists, painters, sculptors, and students. 123 illustrations.

by: David Gross
publisher: Springer, published: 2010-10-29
ASIN: 1441930701
EAN: 9781441930705
sales rank: 4640581
Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.

publisher: CRC Press, published: 2009-04-01
ASIN: 1420080113
EAN: 9781420080117
sales rank: 321440

10+ Years’ of Updates Since First Edition

Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition collates information widely dispersed in journals and book chapters, focusing on the most-relevant literature to experimental toxicology and its distinction from human medicine.

Expands Discussion of Troponins, Lipids, and Electrolytes

In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well-controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology.

Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists.


publisher: CRC Press, published: 2002-12-27
ASIN: 0849310849
EAN: 9780849310843
sales rank: 3027565
The conservative nature of animal evolution makes animal models the ideal tool for learning about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume II addresses the development and application of models in different areas of biomedical research and details the criteria used to choose animal species and strains. This book is not restricted to laboratory animal models for the study of human diseases. Building on the foundation of the best-selling first edition, the second edition includes many new topics such as animal models in skeletal disease, xenotransplantation, and dental disorders.

publisher: Academic Press, published: 2005-11-17
ASIN: 0120802619
EAN: 9780120802616
sales rank: 1030530
A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included.

* Two-color, user-friendly format, with copious illustrations and color plates
* Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

publisher: Humana Press, published: 2011-06-21
ASIN: 1617791563
EAN: 9781617791567
sales rank: 6180624
Animal models of schizophrenia and other major psychiatric disorders have been sought for decades, and, as a result, we are now facing new vistas on pathophysiology that could lead to novel therapeutic approaches and even hint at possible preventive strategies. Animal Models of Schizophrenia and Related Disorders presents an overview of the information that can be obtained with several different models and a detailed account of how to generate such models in order to ensure that the manipulations used to model schizophrenia-relevant phenomena are used consistently across laboratories.  This detailed volume features pharmacological models such as non-competing NMDA antagonists, emphasizing their use in vitro, neurodevelopmental models such as the neonatal ventral hippocampal lesion and the antimitotic MAM, models that reproduce environmental factors such as neonatal hypoxia, vitamin D deficits, and prenatal immune activation, as well as several different genetic model approaches.  As a volume in the Neuromethods series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Practical and cutting-edge, Animal Models of Schizophrenia and Related Disorders highlights the successes in the use of animal models to gain insight on pathophysiological mechanisms of relevance to major psychiatric disorders in the hope of inspiring investigators to expand the research and test targets that could restore or ameliorate function.

by: R. Ian Freshney
publisher: Wiley-Blackwell, published: 2010-09-17
ASIN: 0470528125
EAN: 9780470528129
sales rank: 56282
This is the most complete resource on the techniques, equipment, principles, and practices of animal cell culture.

Since publication of the previous edition of this benchmark text, numerous types of equipment and materials have changed and new specialized techniques have been developed, particularly in the area of stem cell research and tissue engineering. These and other developments have been incorporated into this rigorously revised and expanded sixth edition of Culture of Animal Cells, the leading text in the basic methodology of cell culture.

This authoritative volume offers a complete background related to growth of animal cells in culture. It contains many specialized protocols and advice on how to apply some of the basic protocols to teaching cell culture. Beginning with laboratory design, safety, validation, and bioethics, then continuing with preparation of media, primary culture, and cell lines through to characterization and authentication, contamination, specialized techniques, and troubleshooting, the unparalleled coverage includes:

  • An all-new section addressing the additional caution required once a primary culture is converted to a cell line

  • Differentiation in stem cells and reprogramming of adult cells to form stem cells

  • A new section and protocol on cryopreservation by vitrification

  • Separate sections dealing with epithelial cells, mesenchymal cells, neurectodermal cells, and hematopoietic cells, a new chapter on germs cells/stemcells/amniocytes

  • A new section on organotypic culture

  • Increased emphasis on contamination and misidentification (including cross-contamination) with revised protocols for detection and elimination

  • A problem-solving chapter, glossary of terms, advice on sourcing materials, and list of suppliers

This landmark text presents the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells and is indispensable for those in the field, including clinical and biopharmaceutical researchers and scientists, graduate students, laboratory managers in cell and molecular biology labs and genetics labs, trainees, and technicians.

Q&A with Author R. Ian Freshney, PhD.
Author R. Ian Freshney, PhD.
R. Ian Freshney, PhD, is an honorary Senior Research Fellow in the Centre for Oncology and Applied Pharmacology at the University of Glasgow. He is a world-renowned expert on cell culture technique and has authored and edited numerous successful books, including the hugely popular Culture of Animal Cells (now in its 6th Edition), and Culture of Human Stem Cells.

Culture of Animal Cells: A Manual of Basic Technique and Specialized Application, 6th Ed has been very well received by the scientific community, as have many of your other titles. What do you think sets your books apart and makes them so successful compared to other titles in the field?
I would say there are three major components: (1) The books are designed as practical guides with detailed single-step instructions which should be sufficient without further recourse to the literature. (2) The preparation and sources of materials are explained in detail. (3) Most of the basic protocols are illustrated with easy-to-follow diagrams.

What challenges did you face while putting together Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, 6th Edition?
I struggled with the need to update but at the same time preserve basic procedures which have not changed markedly from the previous edition. This, of course, led to the dilemma of deciding what to retain and what to leave out. I also thought long and hard about what specialized protocols to add without compromising the basic technique role of the book.

What do you find rewarding about authoring and editing books in the sciences?
It forces me to keep up-to-date with developments in cell culture, and in turn helps me to be a better teacher of cell culture. I also get satisfaction from converting what are sometimes complex instructions into one simple straightforward procedure.

What inspired you to write your first book?
I was invited to prepare a textbook on cell culture for a college course. Previously, I had used John Paul’s book, Cell and Tissue Culture, and knew it needed to be updated.

What advice would you offer to scientists writing or editing their first book?
- Determine the precise niche that you wish to fill.
- Plan the structure carefully beforehand but do not be afraid to deviate, within reason, to meet new demands.
- Ensure the text is well illustrated with tables and diagrams.
- Make sure the book is properly cross-referenced.
- Prepare the index yourself. Even if it is to be professionally indexed you will find terms that the indexer does not.

How would you compare the experiences of writing a book and writing a journal article?
Both require a clear concise style, but the author has more freedom to express ideas and opinions when writing a book. Another major difference is that a scientific paper must address a specific topic and provide proof to substantiate the conclusions that are drawn, while a book draws on the author’s and other scientists’ experience to provide a more general review and specific guidelines or instructions.

Do you find that the role of books in the scientific research community has changed over the years? Are they valued more or less today than they were 10-20 years ago?
Rapid changes in technology mean that some books will become outdated without regular updates, which are not always feasible in printed copy. Yet, while there is an increasing tendency to provide instructions and protocols online, many people will still find reassurance from using a textbook with an established reputation.

How do you envision the evolution of science writing over the next 5-10 years?
Certain journals will still tend to be regarded as more reliable than others, as indicated by their citation indices. However, the number of free public access journals will probably increase, presumably with payment to submit articles. There will be a continuing need for editorial control of journal content due to the proliferation of unedited, non-reviewed material appearing online.

What do you feel has been the most significant scientific discovery that has been made during your lifetime?
I can really only speak for biology where the elaboration of the genetic code is probably the most significant development. The ability to regulate gene expression and the resultant plasticity of the cell phenotype will create major opportunities in cell culture and its relevance to tissue in vivo.

What are you reading right now?
This questionnaire! Otherwise, mostly novels and current journals for which I have alerts.


by: Penelope Smith
publisher: Atria Books/Beyond Words, published: 2009-08-04
ASIN: 1582702357
EAN: 9781582702353
sales rank: 233457

The trusted guidebook for animal lovers that describes the astonishing ways in which humans can speak with—and listen to—all creatures.

In this comprehensive follow-up to the widely popular Animal Talk, a respected leader and pioneer in the field of interspecies communication, Penelope Smith, outlines advanced techniques for conversing with animals. She explains that since animals think and perceive differently from humans, readers need to have a true willingness to share, listen, and learn to successfully communicate with them. Although most humans assume that an animal functions on pure instinct, unaware of its own past or future, that’s just not the case. Many subtle secrets about the world can be gleaned from animals once readers know how to see the world through their eyes. Cats, dogs, and other domesticated animals may be more receptive to communicating with humans, but they’re certainly not the only ones with fascinating information to share—Smith shows how humans are also able to speak with roosters, rabbits, insects, llamas, snakes, and many others in the animal kingdom. In addition to chapters devoted to developing and enhancing mind-to-mind communication with animals, When Animals Speak includes an illuminating look at animals as healers, teachers, and guides and even delves into more abstract, advanced forms of interspecies communication, such as contacting spirits of nature. In this accessible book, Smith is sure to delight and instruct animal lovers interested in forging a new bond with animal beings and the natural world.

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