Related books on 'c-elegans'
Return to life science book listNumber of products: 5334
Page 2 of 534
|
publisher: Academic Press, published: 2012-01-30 ASIN: 0123946204 EAN: 9780123946201 sales rank: 1183832 An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come. *Diverse, up-to-date techniques covered will be useful to the broadening community of C. elegans researchers for years to come * Chapters written by leaders in the field * Tried and true methods deliver busy researchers a one-stop compendium of essential protocols |
|
by: William B Wood publisher: Cold Spring Harbor Laboratory Press, published: 1988-06-01 ASIN: 0879694335 EAN: 9780879694333 sales rank: 1128416 In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. Since then, with the help of a growing number of investigators, knowledge about the biology of;the worm; has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete;wiring diagram; of cell contacts in the animal. Recent years have also brought the first successes in molecularly cloning genes of developmental interest defined only by mutation, using transposon tagging as a generally applicable method for identification of the desired DNA sequences. Reintroduction of cloned DNA sequences into the genome has recently been accomplished. A physical map of the genome has been assembled with a combination of cosmid and YAC genes. This;Book of the Worm; serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists |
|
publisher: Springer, published: 2012-01-30 ASIN: 1461416795 EAN: 9781461416791 sales rank: 2105771 In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes. |
|
by: Edward C. Holmes publisher: Oxford University Press, USA, published: 2009-08-31 ASIN: 0199211132 EAN: 9780199211135 sales rank: 618465 RNA viruses provide unique insights into the patterns and processes of evolutionary change in real time. The study of viral evolution is especially topical given the growing awareness that emerging and re-emerging diseases (most of which are caused by RNA viruses) represent a major threat to public health. However, while the study of viral evolution has developed rapidly in the last 30 years, relatively little attention has been directed toward linking work on the mechanisms of viral evolution within cells or individual hosts, to the epidemiological outcomes of these processes. This novel book fills this gap by considering the patterns and processes of viral evolution across their entire range of spatial and temporal scales. The Evolution and Emergence of RNA Viruses provides a comprehensive overview of RNA virus evolution. This is the first book to link mechanisms of viral evolution to epidemiological outcomes, incorporating case studies in RNA virus emergence and evolution using topical examples such as influenza, HIV, dengue fever, and rabies. It reveals the underlying evolutionary processes by which emerging viruses cross species boundaries and spread in new hosts. |
|
by: Daniel L. Hartl publisher: Jones & Bartlett Publishers, published: 2009-12-30 ASIN: 0763773646 EAN: 9780763773649 sales rank: 129287 Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion. |
|
by: Theodore C. Goldsmith publisher: Azinet LLC, published: 2006-10-01 ASIN: 0978870905 EAN: 9780978870904 sales rank: 2030108 Why do we age? Scientists have been baffled by this question for centuries and disagree regarding even the general nature of aging. Is aging the result of fundamental limitations that apply to all living things, or are organisms designed by nature to age because a limited life span conveys some advantage? All of the theories either fail to fully explain observed animal characteristics or conflict with generally accepted evolution theory. This issue has potentially enormous implications for medicine. If aging is the result of fundamental and unalterable forces of nature, then anti-aging medicine is impossible and anti-aging research is futile and foolish. If aging is imposed by an evolved life span regulation system, then research will likely reveal means for altering the operation of the aging mechanism and thereby improve the treatment of many age-related diseases and conditions. This book provides a historical review of biological aging theories including underlying evolution and genetics issues and describes exciting recent discoveries and new theories that are causing renewed interest in aging-by-design. The author discusses Darwin's theory of evolution as well as more recent proposed modifications such as the selfish gene theory, evolvability theory, and group selection in connection with their effects on aging theory. A chapter is devoted to describing the aspects of modern genetics that have implications for evolution theory including the application of digital information theory to genetics. |
|
publisher: Springer, published: 2004-01-05 ASIN: 3540646485 EAN: 9783540646488 Die gesamte Onkologie – verlässliches Wissen für Ihre Kompetenz! "Die Onkologie" stellt sich der Herausforderung, das ständig wachsende Wissen über Tumorerkrankungen in seiner Gesamtheit zu vermitteln. Sowohl inhaltlich als auch didaktisch auf höchstem Niveau: Fundiertes Grundlagenwissen zum umfassenden Nachschlagen Praxisrelevantes Know-how für Diagnostik und Therapie Systematischer Aufbau für das Verständnis der komplexen Zusammenhänge Angesehene Experten aus Klinik, Forschung und Praxis liefern Ihnen in Teil1 Klinisches Grundlagenwissen zu den Grundprinzipien der Therapie, Epidemiologie, Ätiologie und Pathogenese, sowie zu Komplikationen des malignen Wachstums. Teil 2 enthält umsetzbare und aktuelle Empfehlungen zu Diagnostik und Therapie aller relevanten soliden Tumoren und malignen Systemerkrankungen. Zum Nachschlagen und Anwenden: Finden Sie alle Optionen - auch für Ihren schwierigsten Fall. Der übersichtliche Aufbau und die exzellenten Abbildungen erleichtern Ihnen das schnelle Auffinden und Verständnis der gesuchten Informationen. Für den Alltag onkologisch tätiger Ärzte ist Die Onkologie ein unentbehrlicher Meilenstein. |
|
publisher: Springer, published: 2008-10-14 ASIN: 1402088426 EAN: 9781402088421 sales rank: 6069165 The cytoskeleton is a key intracellular structure governing relevant processes such as cell division, growth, molecule trafficking, response to internal and external signals, and others. The ambitious aim of this monograph is to deal with the cytoskeleton as the ‘server’ for these numerous and multi-tasked nodes. The monograph’s content focuses on problems relevant to understanding the structural and functional organisation of the plant cytoskeleton at the single cell and whole plant levels, including the possibility of directly utilizing these functions for practical purposes in agriculture, food safety and health. As a result of advances in plant genomics, cell and molecular biology, special chapters represent new information about genomics, proteomics and bioinformatics of the plant cytoskeleton. In addition to presenting achievements attained in basic research of the plant cytoskeleton, a comprehensive review of applications in biotechnology and agriculture is presented. Special attention is devoted to current achievements in plant biotechnology through manipulating the cytoskeleton structure and functions, and prospects for the development in different professional venues, including industrial/agricultural implementation. |
|
by: Robert R. H. Anholt publisher: Academic Press, published: 2009-09-29 ASIN: 0123725755 EAN: 9780123725752 sales rank: 518814 How do genes determine behavior? How much of behavior is nature versus nurture? How do behaviors evolve? Anholt and Mackay, leading scholars in the field of behavioral genetics, address these questions and much more in this comprehensive textbook that defines the emerging field of behavioral genetics. The provides a range of examples, such as laboratory studies on flies and mice, field observations on species as diverse as butterflies and meerkats, and human behavioral disorders. The book blends classical and modern genetic principles with neurobiological and ecological perspectives to teach students how to find and map genes that affect behaviors, as well as how the coordinated expression of ensembles of these genes enables the nervous system to express complex behaviors in response to changes in the environment. Principles of Behavioral Genetics introduces us to the fascinating science that aims to understand how our genes determine what makes us tick. Principles of Behavioral Genetics presents a comprehensive overview of the relationship between genes, brain and behavior. Introductory chapters provide clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior. Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field. All chapters contain general overviews, concise summaries, study questions that promote not only memorization but also contemplation of the material, and recommendations for further in-depth reading. An extensive glossary that defines the terminology used in the book is included. This textbook encompasses a broad definition of the emerging science of behavioral genetics. *Defines the emerging science of behavioral genetics *Engagingly written by two leading experts in behavioral genetics *Clear explanations of basic quantitative genetic, neurogenetic and genomic applications to the study of behavior *Numerous examples ranging from model organisms to non model systems and humans *Concise overviews and summaries for each chapter |
|
publisher: Humana Press, published: 2010-12-09 ASIN: 1617375934 EAN: 9781617375934 sales rank: 4677200 This extensively expanded and updated edition reflects the enormous increase in our knowledge of the development of the nervous system. Working from a new understanding that the regionalization of stem cells occurs early in development and that this bias appears to persist even after prolonged culture, Dr. Rao has added additional chapters on olfactory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone-derived neural stem cells. A new chapter on cell death summarizes the important changes in the death pathway that occurs as stem cells mature. Special attention is paid to the derivation of neural cells from embryonic stem cells. Authoritative and up-to-date, Neural Development and Stem Cells, Second Edition provides neuroscientists with a handy guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from differentiation to neurons, astrocytes, and oligodendrocytes. |