Related books on 'epigenetics chromatin'
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by: Nelson R Cabej publisher: Elsevier, published: 2011-12-05 ASIN: 0124158315 EAN: 9780124158313 sales rank: 1724006 This is the first and only book, so far, to deal with the causal basis of evolution from an epigenetic view. By revealing the epigenetic "user" of the "genetic toolkit", this book demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theory with a host of examples from the most varied fields of biology, by emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans.
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publisher: Springer, published: 2009-02-13 ASIN: 1402091869 EAN: 9781402091865 sales rank: 1967709 Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times. The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease. The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum. |
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by: B. M. Turner publisher: Wiley-Blackwell, published: 2002-02-11 ASIN: 0865427437 EAN: 9780865427433 sales rank: 1370571 Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression. |
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publisher: Springer, published: 2009-11-18 ASIN: 144190638X EAN: 9781441906380 sales rank: 400060 Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible. |
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publisher: Wiley-VCH, published: 2009-08-12 ASIN: 3527323554 EAN: 9783527323555 sales rank: 906362 Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug. |
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by: Richard C. Francis publisher: W. W. Norton & Company, published: 2011-06-13 ASIN: 0393070050 EAN: 9780393070057 sales rank: 36948 Time to worry again—our lifestyle choices do impact our genetic code and that of our children (and even grandchildren!). "The potential is staggering. . . . The age of epigenetics has arrived."—Time, January 2010Epigenetic means "on the gene," and the term refers to the recent discovery that stress in the environment can impact an individual's physiology so deeply that those biological scars are actually inherited by the next several generations. For instance, a recent study has shown that men who started smoking before puberty caused their sons to have significantly higher rates of obesity. And obesity is just the tip of the iceberg—many researchers believe that epigenetics holds the key to understanding cancer, Alzheimer's, schizophrenia, autism, and diabetes. Epigenetics is the first book for general readers on this fascinating and important topic. The book is driven by stories such as the Dutch famine of World War II, José Canseco and steroids, the breeding of mules and hinnies, Tazmanian devils and contagious cancer, and more. 18 illustrations |
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publisher: CRC Press, published: 2008-09-19 ASIN: 1420045792 EAN: 9781420045796 sales rank: 2302078 During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers— Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field. |
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publisher: Springer, published: 2005-05-25 ASIN: B000PY3UR6 sales rank: 721332 Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other. |
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by: Francesco Chiappelli publisher: Biomedical Informatics Publishing Group, published: 2008-01-01 ASIN: B0026BXB20 This digital document is an article from Bioinformation, published by Biomedical Informatics Publishing Group on January 1, 2008. The length of the article is 3501 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. From the author: Keywords: epigenetics; hologenomics; coding and noncoding DNA; human T cells; Tregs; HIV-1; AIDS; neuroAIDS; immunopathology; translational evidence-based decision-making Citation Details Title: Molecular epigenetics, chromatin, and NeuroAIDS/HIV: immunopathological implications.(Current Trends) Author: Francesco Chiappelli Publication: Bioinformation (Magazine/Journal) Date: January 1, 2008 Publisher: Biomedical Informatics Publishing Group Page: 47(6) Distributed by Gale, a part of Cengage Learning |
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by: Paul Shapshak publisher: Biomedical Informatics Publishing Group, published: 2008-01-01 ASIN: B0026BXB2A This digital document is an article from Bioinformation, published by Biomedical Informatics Publishing Group on January 1, 2008. The length of the article is 3485 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. From the author: Keywords: epigenetics; hologenomics; coding and noncoding DNA; HIV-1; AIDS; NeuroAIDS; molecular medicine paradigmshift; translation-clinic Citation Details Title: Molecular epigenetics, chromatin, and NeuroAIDS/HIV: translational implications.(Current Trends) Author: Paul Shapshak Publication: Bioinformation (Magazine/Journal) Date: January 1, 2008 Publisher: Biomedical Informatics Publishing Group Page: 53(5) Distributed by Gale, a part of Cengage Learning |