gene-delivery-or-gene-transfer books

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Transgenic Crop Plants: Volume 1: Principles and Development

publisher: Springer, published: 2010-02-03
ASIN: 3642048080
EAN: 9783642048081
sales rank: 3549156
Development of transgenic crop plants, their utilization for improved agriculture, health, ecology and environment and their socio-political impacts are currently important fields in education, research and industries and also of interest to policy makers, social activists and regulatory and funding agencies. This work prepared with a class-room approach on this multidisciplinary subject will fill an existing gap and meet the requirements of such a broad section of readers. Volume 1 with ten chapters contributed by 31 eminent scientists from nine countries deliberates on the basic concepts, strategies and tools for development of transgenic crop plants, including topics such as: explants used for the generation of transgenic plants, gene transfer methods, organelle transformation, selection and screening strategies, expression and stability of transgenes, silencing undesirable genes, transgene integration, biosynthesis and biotransformation and metabolic engineering of pathways and gene discovery.

Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applications

publisher: Springer, published: 2011-11-10
ASIN: 1461410797
EAN: 9781461410799
Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

Gene Delivery to Mammalian Cells: Volume 2: Viral Gene Transfer Techniques (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-10
ASIN: 1617373532
EAN: 9781617373534
sales rank: 3778045
Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors. An accompanying volume, Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics.

Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine

publisher: Springer, published: 2005-12-21
ASIN: 1852339799
EAN: 9781852339791
sales rank: 2390814
Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Prenatal Gene Therapy: Concepts, Methods, and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2012-05-31
ASIN: 161779872X
EAN: 9781617798726

Nonviral Vectors for Gene Therapy

publisher: Academic Press, published: 1999-06-21
ASIN: 0123584655
EAN: 9780123584656
sales rank: 2637966
Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.
Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians.

Key Features
* Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine
* Covers all types of nonviral vectors, from molecular structure to therapeutic application
Provides a comprehensive review of synthetic vectors
* Includes contributions from major investigators and leading experts in the field

Biosurfactants: From Genes to Applications (Microbiology Monographs)

publisher: Springer, published: 2010-09-30
ASIN: 3642144896
EAN: 9783642144899
sales rank: 3040434
Biosurfactants, tensio-active compounds produced by living cells, are now gaining increasing interest due to their potential applications in many different industrial areas in which to date almost exclusively synthetic surfactants have been used. Their unique structures and characteristics are just starting to be appreciated. In addition, biosurfactants are considered to be environmentally “friendly,” relatively non-toxic and biodegradable. This Microbiology Monographs volume deals with the most recent advances in the field of microbial biosurfactants, such as rhamnolipids, serrawettins, trehalolipids, mannosylerythritol lipids, sophorolipids, surfactin and other lipopeptides. Each chapter reviews the characteristics of an individual biosurfactant including the physicochemical properties, the chemical structures, the role in the physiology of the producing microbes, the biosynthetic pathways, the genetic regulation, and the potential biotechnological applications.

Oxygen, Gene Expression, and Cellular Function (Lung Biology in Health and Disease)

by: Clerch/Massaro
publisher: Informa Healthcare, published: 1997-05-15
ASIN: 0824700627
EAN: 9780824700621
sales rank: 3576408

This concise, well-focused reference addresses the impact of oxygen on evolution and ontogeny-furnishing both animal and cellular models that investigate the use of oxygen in humans for the treatment of various diseases and conditions.

Cellular Drug Delivery: Principles and Practice

publisher: Humana Press, published: 2010-11-05
ASIN: 1617374555
EAN: 9781617374555
An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

Gene Therapy in the Treatment of Cancer: Progress and Prospects (Cancer: Clinical Science in Practice)

publisher: Cambridge University Press, published: 1999-01-28
ASIN: 0521444365
EAN: 9780521444361
sales rank: 6841987
The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the past two decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks toward future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the ground-breaking work of the contributors themselves. Up to date and authoritative, the volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

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	Transgenic Crop Plants: Volume 1: Principles and Development publisher: Springer, published: 2010-02-03 ASIN: 3642048080 EAN: 9783642048081 sales rank: 3549156 Development of transgenic crop plants, their utilization for improved agriculture, health, ecology and environment and their socio-political impacts are currently important fields in education, research and industries and also of interest to policy makers, social activists and regulatory and funding agencies. This work prepared with a class-room approach on this multidisciplinary subject will fill an existing gap and meet the requirements of such a broad section of readers. Volume 1 with ten chapters contributed by 31 eminent scientists from nine countries deliberates on the basic concepts, strategies and tools for development of transgenic crop plants, including topics such as: explants used for the generation of transgenic plants, gene transfer methods, organelle transformation, selection and screening strategies, expression and stability of transgenes, silencing undesirable genes, transgene integration, biosynthesis and biotransformation and metabolic engineering of pathways and gene discovery.
	Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applications publisher: Springer, published: 2011-11-10 ASIN: 1461410797 EAN: 9781461410799 Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.
	Gene Delivery to Mammalian Cells: Volume 2: Viral Gene Transfer Techniques (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-10 ASIN: 1617373532 EAN: 9781617373534 sales rank: 3778045 Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors. An accompanying volume, Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics.
	Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine publisher: Springer, published: 2005-12-21 ASIN: 1852339799 EAN: 9781852339791 sales rank: 2390814 Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.
	Prenatal Gene Therapy: Concepts, Methods, and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2012-05-31 ASIN: 161779872X EAN: 9781617798726
	Nonviral Vectors for Gene Therapy publisher: Academic Press, published: 1999-06-21 ASIN: 0123584655 EAN: 9780123584656 sales rank: 2637966 Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field
	Biosurfactants: From Genes to Applications (Microbiology Monographs) publisher: Springer, published: 2010-09-30 ASIN: 3642144896 EAN: 9783642144899 sales rank: 3040434 Biosurfactants, tensio-active compounds produced by living cells, are now gaining increasing interest due to their potential applications in many different industrial areas in which to date almost exclusively synthetic surfactants have been used. Their unique structures and characteristics are just starting to be appreciated. In addition, biosurfactants are considered to be environmentally “friendly,” relatively non-toxic and biodegradable. This Microbiology Monographs volume deals with the most recent advances in the field of microbial biosurfactants, such as rhamnolipids, serrawettins, trehalolipids, mannosylerythritol lipids, sophorolipids, surfactin and other lipopeptides. Each chapter reviews the characteristics of an individual biosurfactant including the physicochemical properties, the chemical structures, the role in the physiology of the producing microbes, the biosynthetic pathways, the genetic regulation, and the potential biotechnological applications.
	Oxygen, Gene Expression, and Cellular Function (Lung Biology in Health and Disease) by: Clerch/Massaro publisher: Informa Healthcare, published: 1997-05-15 ASIN: 0824700627 EAN: 9780824700621 sales rank: 3576408 This concise, well-focused reference addresses the impact of oxygen on evolution and ontogeny-furnishing both animal and cellular models that investigate the use of oxygen in humans for the treatment of various diseases and conditions.
	Cellular Drug Delivery: Principles and Practice publisher: Humana Press, published: 2010-11-05 ASIN: 1617374555 EAN: 9781617374555 An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.
	Gene Therapy in the Treatment of Cancer: Progress and Prospects (Cancer: Clinical Science in Practice) publisher: Cambridge University Press, published: 1999-01-28 ASIN: 0521444365 EAN: 9780521444361 sales rank: 6841987 The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the past two decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks toward future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the ground-breaking work of the contributors themselves. Up to date and authoritative, the volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.