genomics books

Related books on 'genomics'

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Here Is a Human Being: At the Dawn of Personal Genomics

by: Misha Angrist
publisher: Harper, published: 2010-11-01
ASIN: B0058M5HY4
sales rank: 330755

The first in-depth look at personal genomics: its larger-than-life research subjects; its entrepreneurs and do-it-yourselfers; its technology developers; the bewildered and overwhelmed physicians and regulators who must negotiate it; and what it means to be a "public genome" in a world where privacy is already under siege

In 2007, Misha Angrist became the fourth subject in the Personal Genome Project, George Church's ambitious plan to sequence the entire genomic catalog: every participant's twenty thousand–plus genes and the rest of his or her 6 billion base pairs. Church hopes to better understand how genes influence our physical traits, from height and athletic ability to behavior and weight, and our medical conditions, from cancer and diabetes to obesity and male pattern baldness. Now Angrist reveals startling information about the experiment's participants and scientists; how the experiment was, is, and will be conducted; the discoveries and potential discoveries; and the profound implications of having an unfiltered view of our hardwired selves for us and for our children.

DNA technology has already changed our health care, the food we eat, and our criminal justice system. Unlocking the secrets of our genomes opens the door not only to helping us understand why we are the way we are and potentially fixing what ails us but also to many other concerns: What exactly will happen to this information? Will it become just another marketing tool? Can it help us understand our ancestry, or will it merely reinforce old ideas of race? Can personal genomics help fix the U.S. health care system?

Here Is a Human Being explores these complicated questions while documenting Angrist's own fascinating journey—one that tens of thousands of us will soon make.

Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, Expert Consult: Online and Print, 3e

by: David J. Dabbs MD
publisher: Saunders, published: 2010-01-29
ASIN: 1416057668
EAN: 9781416057666
sales rank: 76361

Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis.
Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.

Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization.

Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors.

Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance.

Features an expert author for each chapter to ensure coverage of the current state of the art.

Includes access to the full text online at expertconsult.com, along with a downloadable image bank and Path Consult.

Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches.

Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results.

Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin's lymphoma.

Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.

Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms.

Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.

Accurately interpret immunohistochemical results and provide the clinician with the best therapeutic approaches for the patient
Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Achieving Justice in Genomic Translation: Re-Thinking the Pathway to Benefit

publisher: Oxford University Press, USA, published: 2011-09-15
ASIN: 0195390385
EAN: 9780195390384
sales rank: 650553
This book explores implicit choices made by researchers, policy makers, and funders regarding who benefits from society's investment in health research. The authors focus specifically on genetic research and examine whether such research tends to reduce or exacerbate existing health disparities. Using case examples to illustrate the issues, the authors trace the path of genetics research from discovery, through development and delivery, to health outcomes. Topics include breast cancer screening and treatment, autism research, pharmacogenetics, prenatal testing, newborn screening, and youth suicide prevention. Each chapter emphasizes the societal context of genetic research and illustrates how science might change if attention were paid to the needs of marginalized populations. Written by experts in genetics, health, and philosophy, this book argues that the scientific enterprise has a responsibility to respond to community needs to assure that research innovations achieve much needed health impacts.

Bioinformatics and the Cell: Modern Computational Approaches in Genomics, Proteomics and Transcriptomics

by: Xuhua Xia
publisher: Springer, published: 2010-11-04
ASIN: 1441943919
EAN: 9781441943910
sales rank: 4085460
The many books that have been published on bioinformatics tend toward either of two extremes: those that feature computational details with a great deal of mathematics, for computational scientists and mathematicians; and those that treat bioinformatics as a giant black box, for biologists. This is the first book using comprehensive numerical illustration of mathematical techniques and computational algorithms used in bioinformatics that converts molecular data into organized biological knowledge.

Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists (Computational Biology)

by: David Wayne Ussery
publisher: Springer, published: 2010-12-09
ASIN: 1849967636
EAN: 9781849967631
sales rank: 2690039
The problem many microbiologists face is simply that of too much information. This book details many published methods for comparison of genomes, and provides examples of how custom comparisons can be made. The choice of methods obviously depends on the questions to be asked, and of course on the quantity of genomes to be compared. Two similar bacterial chromosomes can simply be aligned with each other, and regions of inversions and deletions can be readily visualised. However, this method won’t work to compare hundreds of genomes, where 2-Dimensional clustering heat maps would be useful. This text is built around teaching COMPUTATIONAL / BIOINFORMATIC methods for comparison of microbial genomes, and includes detailed examples of how to compare them at the level of DNA, RNA, and protein, in terms of structural / functional analysis. Aimed at advanced undergraduate and graduate students in Bioinformatics and Microbiology, this book will prove an invaluable reference to computational and bioinformatics tools.

Integrated Genomics: A Discovery-Based Laboratory Course

by: Guy A. Caldwell
publisher: Wiley, published: 2006-09-18
ASIN: 0470095024
EAN: 9780470095027
sales rank: 759997
Integrated Genomics: A Discovery-Based Laboratory Course introduces the excitement of discovery to the basic molecular biology laboratory. Utilizing up-to-date molecular biology protocols and a basic experimental design, this text offers experience with three different model systems. Students will become familiar with the simplicity and power of single-celled organisms, Escherichia coli and Saccharomyces cerevisiae, as they search for genes that interact and function within the nematode Caenorhabditis elegans.
Incorporated throughout the course are exercises designed to offer students familiarity with the wealth of bioinformatics data that can be accessed on the World Wide Web. Following completion of interaction studies within the yeast, the course is designed to allow students to examine the functional consequences of reducing a gene’s function within the multicellular worm that is both simple and inexpensive to maintain within a laboratory. The inclusion of alternative experiments allow for flexibility in determining the ending date or goal of the laboratory, as well as working within the available budget and resources of most any classroom environment.
Further striking features of this title are:
An accompanying Web site providing PowerPoint slides, plus links to the internet, and regular updates as bioinformatics databases evolve and methods improve. www.wiley.com/go/caldwell
Inclusion of modern genomic/proteomic technologies such as the yeast two-hybrid system and RNAi
Detailed experimental protocols and easy access to instructional materials
This discovery-based laboratory course provides excellent practical training for those pursuing career paths in biomedicine, pharmacy, and biotechnology.

Introduction to Protein Science: Architecture, Function, and Genomics

by: Arthur M. Lesk
publisher: Oxford University Press, USA, published: 2010-05-20
ASIN: 0199541302
EAN: 9780199541300
sales rank: 664988
Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked.

Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors.

New to this edition:

* Coverage of new developments in the field, including high-throughput methods
* A new chapter on enzyme kinetics
* Extended treatments of such topics as protein evolution and the immune system
* New pedagogical features including "key points" and "Proteins in Health and Disease" boxes
* New end-of-chapter exercises, problems, and "weblems"

Chemical Genomics and Proteomics, Second Edition

publisher: CRC Press, published: 2012-09-25
ASIN: 1439830525
EAN: 9781439830529
This interdisciplinary reference identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology. The book tracks the emergence of a large variety of novel techniques such as the small-molecule drugability of new targets, the generation and synthesis of small-molecule libraries, and the determination of targets and mechanisms by genomic profiling and guides readers in the selection of the most appropriate technology for their specific dilemma by highlighting procedures utilized in other scientific disciplines.

Bovine Genomics

publisher: Wiley-Blackwell, published: 2012-06-05
ASIN: 0813821223
EAN: 9780813821221
sales rank: 2350446
The genetic information being unlocked by advances in genomic and high throughput technologies is rapidly revolutionizing our understanding of developmental processes in bovine species. This information is allowing researchers unprecedented insight into the genetic basis of key traits. Bovine Genomics is the first book to bring together and synthesize the information learned through the bovine genome sequencing project and look at its practical application to cattle and dairy production.
Bovine Genomics opens with foundational chapters on the domestication of cattle and traditional Mendelian genetics. Building on these chapters, coverage rapidly moves to quantitative genetics and the advances of whole genome technologies. Significant coverage is given to such topics as epigenetics, mapping quantitative trail loci, genome-wide association studies and genomic selection in cattle breeding. The book is a valuable synthesis of the field written by a global team of leading researchers.
Providing wide-ranging coverage of the topic, Bovine Genomic, is an essential guide to the field. The basic and applied science will be of use to researchers, breeders, and advanced students.

Introduction to Computational Genomics: A Case Studies Approach

by: Nello Cristianini
publisher: Cambridge University Press, published: 2007-01-15
ASIN: 0521671914
EAN: 9780521671910
sales rank: 559477
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.

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	Here Is a Human Being: At the Dawn of Personal Genomics by: Misha Angrist publisher: Harper, published: 2010-11-01 ASIN: B0058M5HY4 sales rank: 330755 The first in-depth look at personal genomics: its larger-than-life research subjects; its entrepreneurs and do-it-yourselfers; its technology developers; the bewildered and overwhelmed physicians and regulators who must negotiate it; and what it means to be a "public genome" in a world where privacy is already under siege In 2007, Misha Angrist became the fourth subject in the Personal Genome Project, George Church's ambitious plan to sequence the entire genomic catalog: every participant's twenty thousand–plus genes and the rest of his or her 6 billion base pairs. Church hopes to better understand how genes influence our physical traits, from height and athletic ability to behavior and weight, and our medical conditions, from cancer and diabetes to obesity and male pattern baldness. Now Angrist reveals startling information about the experiment's participants and scientists; how the experiment was, is, and will be conducted; the discoveries and potential discoveries; and the profound implications of having an unfiltered view of our hardwired selves for us and for our children. DNA technology has already changed our health care, the food we eat, and our criminal justice system. Unlocking the secrets of our genomes opens the door not only to helping us understand why we are the way we are and potentially fixing what ails us but also to many other concerns: What exactly will happen to this information? Will it become just another marketing tool? Can it help us understand our ancestry, or will it merely reinforce old ideas of race? Can personal genomics help fix the U.S. health care system? Here Is a Human Being explores these complicated questions while documenting Angrist's own fascinating journey—one that tens of thousands of us will soon make.
	Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, Expert Consult: Online and Print, 3e by: David J. Dabbs MD publisher: Saunders, published: 2010-01-29 ASIN: 1416057668 EAN: 9781416057666 sales rank: 76361 Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art. Includes access to the full text online at expertconsult.com, along with a downloadable image bank and Path Consult. Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches. Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results. Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin's lymphoma. Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms. Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach. Accurately interpret immunohistochemical results and provide the clinician with the best therapeutic approaches for the patient Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
	Achieving Justice in Genomic Translation: Re-Thinking the Pathway to Benefit publisher: Oxford University Press, USA, published: 2011-09-15 ASIN: 0195390385 EAN: 9780195390384 sales rank: 650553 This book explores implicit choices made by researchers, policy makers, and funders regarding who benefits from society's investment in health research. The authors focus specifically on genetic research and examine whether such research tends to reduce or exacerbate existing health disparities. Using case examples to illustrate the issues, the authors trace the path of genetics research from discovery, through development and delivery, to health outcomes. Topics include breast cancer screening and treatment, autism research, pharmacogenetics, prenatal testing, newborn screening, and youth suicide prevention. Each chapter emphasizes the societal context of genetic research and illustrates how science might change if attention were paid to the needs of marginalized populations. Written by experts in genetics, health, and philosophy, this book argues that the scientific enterprise has a responsibility to respond to community needs to assure that research innovations achieve much needed health impacts.
	Bioinformatics and the Cell: Modern Computational Approaches in Genomics, Proteomics and Transcriptomics by: Xuhua Xia publisher: Springer, published: 2010-11-04 ASIN: 1441943919 EAN: 9781441943910 sales rank: 4085460 The many books that have been published on bioinformatics tend toward either of two extremes: those that feature computational details with a great deal of mathematics, for computational scientists and mathematicians; and those that treat bioinformatics as a giant black box, for biologists. This is the first book using comprehensive numerical illustration of mathematical techniques and computational algorithms used in bioinformatics that converts molecular data into organized biological knowledge.
	Computing for Comparative Microbial Genomics: Bioinformatics for Microbiologists (Computational Biology) by: David Wayne Ussery publisher: Springer, published: 2010-12-09 ASIN: 1849967636 EAN: 9781849967631 sales rank: 2690039 The problem many microbiologists face is simply that of too much information. This book details many published methods for comparison of genomes, and provides examples of how custom comparisons can be made. The choice of methods obviously depends on the questions to be asked, and of course on the quantity of genomes to be compared. Two similar bacterial chromosomes can simply be aligned with each other, and regions of inversions and deletions can be readily visualised. However, this method won’t work to compare hundreds of genomes, where 2-Dimensional clustering heat maps would be useful. This text is built around teaching COMPUTATIONAL / BIOINFORMATIC methods for comparison of microbial genomes, and includes detailed examples of how to compare them at the level of DNA, RNA, and protein, in terms of structural / functional analysis. Aimed at advanced undergraduate and graduate students in Bioinformatics and Microbiology, this book will prove an invaluable reference to computational and bioinformatics tools.
	Integrated Genomics: A Discovery-Based Laboratory Course by: Guy A. Caldwell publisher: Wiley, published: 2006-09-18 ASIN: 0470095024 EAN: 9780470095027 sales rank: 759997 **Integrated Genomics: A Discovery-Based Laboratory Course** introduces the excitement of discovery to the basic molecular biology laboratory. Utilizing up-to-date molecular biology protocols and a basic experimental design, this text offers experience with three different model systems. Students will become familiar with the simplicity and power of single-celled organisms, Escherichia coli and Saccharomyces cerevisiae, as they search for genes that interact and function within the nematode Caenorhabditis elegans. Incorporated throughout the course are exercises designed to offer students familiarity with the wealth of bioinformatics data that can be accessed on the World Wide Web. Following completion of interaction studies within the yeast, the course is designed to allow students to examine the functional consequences of reducing a gene’s function within the multicellular worm that is both simple and inexpensive to maintain within a laboratory. The inclusion of alternative experiments allow for flexibility in determining the ending date or goal of the laboratory, as well as working within the available budget and resources of most any classroom environment. Further striking features of this title are: An accompanying Web site providing PowerPoint slides, plus links to the internet, and regular updates as bioinformatics databases evolve and methods improve. www.wiley.com/go/caldwell Inclusion of modern genomic/proteomic technologies such as the yeast two-hybrid system and RNAi Detailed experimental protocols and easy access to instructional materials This discovery-based laboratory course provides excellent practical training for those pursuing career paths in biomedicine, pharmacy, and biotechnology.
	Introduction to Protein Science: Architecture, Function, and Genomics by: Arthur M. Lesk publisher: Oxford University Press, USA, published: 2010-05-20 ASIN: 0199541302 EAN: 9780199541300 sales rank: 664988 Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked. Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors. New to this edition: * Coverage of new developments in the field, including high-throughput methods * A new chapter on enzyme kinetics * Extended treatments of such topics as protein evolution and the immune system * New pedagogical features including "key points" and "Proteins in Health and Disease" boxes * New end-of-chapter exercises, problems, and "weblems"
	Chemical Genomics and Proteomics, Second Edition publisher: CRC Press, published: 2012-09-25 ASIN: 1439830525 EAN: 9781439830529 This interdisciplinary reference identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology. The book tracks the emergence of a large variety of novel techniques such as the small-molecule drugability of new targets, the generation and synthesis of small-molecule libraries, and the determination of targets and mechanisms by genomic profiling and guides readers in the selection of the most appropriate technology for their specific dilemma by highlighting procedures utilized in other scientific disciplines.
	Bovine Genomics publisher: Wiley-Blackwell, published: 2012-06-05 ASIN: 0813821223 EAN: 9780813821221 sales rank: 2350446 The genetic information being unlocked by advances in genomic and high throughput technologies is rapidly revolutionizing our understanding of developmental processes in bovine species. This information is allowing researchers unprecedented insight into the genetic basis of key traits. Bovine Genomics is the first book to bring together and synthesize the information learned through the bovine genome sequencing project and look at its practical application to cattle and dairy production. Bovine Genomics opens with foundational chapters on the domestication of cattle and traditional Mendelian genetics. Building on these chapters, coverage rapidly moves to quantitative genetics and the advances of whole genome technologies. Significant coverage is given to such topics as epigenetics, mapping quantitative trail loci, genome-wide association studies and genomic selection in cattle breeding. The book is a valuable synthesis of the field written by a global team of leading researchers. Providing wide-ranging coverage of the topic, Bovine Genomic, is an essential guide to the field. The basic and applied science will be of use to researchers, breeders, and advanced students.
	Introduction to Computational Genomics: A Case Studies Approach by: Nello Cristianini publisher: Cambridge University Press, published: 2007-01-15 ASIN: 0521671914 EAN: 9780521671910 sales rank: 559477 Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.