pharmacogenomics books

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An A-Z Guide to Pharmacogenomics

by: Michael G. Catania
publisher: American Association for Clinical Chemistry, published: 2006-07-14
ASIN: 1594250472
EAN: 9781594250477
sales rank: 2547448
Pharmacogenomics and the concept of customizable, personalized medicine promise to change how physicians treat disease and how drug companies develop and market drugs. Intended for scientists and physicians who have a basic understanding of molecular biology, An A-Z Guide to Pharmacogenomics introduces the terms and techniques common to this fast-paced and high-stakes field and explains them in a straightforward, easy-to-understand way. The impact of pharmacogenomics on medicine will be revolutionary, drawing together a diverse group of scientific disciplines and impacting everything from basic research to the patient's hospital bedside. The terms listed in this A to Z guide reflect this diversity of scope, representing basic biology, bioinformatics, diagnostics, and drug discovery. The pharmacogenomics revolution has already begun -- the FDA recently approved the first genetic test designed to predict an individual's response to a given drug. This guide is a starting point for anyone interested in the technology that will revolutionize medicine and directly impact the health and well-being of millions of people.

Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory (Molecular and Translational Medicine)

publisher: Humana Press, published: 2011-02-17
ASIN: 1607612828
EAN: 9781607612827
sales rank: 2681991
While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field.

Pharmacogenomics: Methods and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-11-19
ASIN: 1617375713
EAN: 9781617375712
sales rank: 5141230
Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

Lexi-Comp's Pharmacogenomics Handbook

by: Larisa M. Humma
publisher: Lexi Comp, published: 2003-07
ASIN: 1591950600
EAN: 9781591950608
sales rank: 5873937
Presents information concerning key genetic variations that may influence drug disposition &/or sensitivity...sections included: intoduction to pharmacogenomics, intro to genetics, polymorphism monographs, definitions/glossary & much more.

Pharmacogenomics: Social, Ethical, and Clinical Dimensions

publisher: Wiley-Liss, published: 2003-01-23
ASIN: 0471227692
EAN: 9780471227694
sales rank: 2945067
Through analyses of the complex underlying issues, this interdisciplinary volume frames the agenda for dealing with genetic variation and incorporating pharmacogenomics into health care. The three sections of this book, Research Issues, Clinical Issues, and Social Perspectives address key elements integral to a comprehensive discussion of this emerging field.
This groundbreaking text…
Examines new research strategies, methodologies, and ethical and social considerations of pharmacogenomics
Addresses practical considerations of anticipated changes in education, training, oversight, guidelines and protocols, and continuing education requirements
Provides analyses of the potential enormous impact of pharmacogenomics, such as in the standard of care and treatment, including perspectives from the fields of anthropology, law, ethics, and economics

Referenced Review Questions in Pharmacogenomics

by: Robert M. White
publisher: AACC Press, published: 2007-07-31
ASIN: 1594250707
EAN: 9781594250705
sales rank: 3010609
The application of pharmacogenomic principles to medication use is beginning to radically change the way drugs are selected and monitored. Those who wish to evaluate their knowledge in the basics of the subject and in applications such as drug selection and drug avoidance will therefore find Referenced Review Questions in Pharmacogenomics an invaluable guide to this rapidly evolving field. The book features three sections:

Questions
Answers and Explanation
References (provided as a basis for the answers and to encourage the reader to review the references and expand his/her knowledge or area of expertise)

The Questions section is further subdivided into the following topics: The Basics; Cytochrome P450s and Other Enzymes; Receptors; N-Acetyl Transferases; Asthma and Other Pulmonary Diseases; Neurology; Antimicrobials and Infectious Disease; Immunology; Oncology; Analgesics, Sedatives, Hypnotics, and Anesthetics; Psychiatry; Antiinflammatory Drugs; Oral Hypoglycemics; Glucose-6-phosphate Dehydrogenase; Anticoagulants; Inflammatory Bowel Disease and Other Gastrointestinal Drugs; Bone and Mineral Metabolism; and Cardiovascular Drugs. A large portion of the specific information on individual drugs is derived from the pharmaceutical industry, which performs the majority of the pharmacogenomics testing as part of pre-market approval.

Because the emerging concept of personalized medicine is placing significant demands on physicians and on pharmacists in particular, they-as well as academic and practicing clinical chemists and pathologists who have an interest in pharmacogenomics-will find Referenced Review Questions in Pharmacogenomics especially useful. Technologists and other healthcare professionals who have an interest in molecular medicine and who would like to broaden their professional horizons will also find this text enlightening.

Pharmacogenomics and Proteomics: Enabling the Practice of Personalized Medicine

by: Steven H. Y. Wong
publisher: AACC Press, published: 2006-05-01
ASIN: 1594250464
EAN: 9781594250460
sales rank: 3153731
The new "molecular economy," fundamentally driven by understanding molecules and their interactions, has spawned an exciting discipline referred to as "clinical" pharmacogenomics or pharmacogenetics. Combining this discipline with our knowledge of protein function and regulation (proteomics), a more complete understanding of systems physiology is achieved-giving rise to a "systems biology" perspective. From this new perspective, the practice of medicine is becoming more dependent on the application of biomarkers-genomics, proteomics, and other functional biomarkers-toward personalized medicine, thus allowing a practical convergence to optimize matching of the right patient and the right diagnosis with the right drug and the right dose at the right time. To enable the practice of personalized medicine with an understanding of pharmacogenomics and proteomics, this book reviews:

the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis;
methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics;
specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and
selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.
As the new molecular economy emerges, this text provides the basic pharmacogenomic and proteomic tools needed to understand this new, rapidly evolving, and exciting discipline.

Pharmacogenomics: Webster's Timeline History, 1997 - 2007

by: Icon Group International
publisher: ICON Group International, Inc., published: 2009-06-06
ASIN: 0546891543
EAN: 9780546891546
sales rank: 5019124
Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Pharmacogenomics," including when used in literature (e.g. all authors that might have Pharmacogenomics in their name). As such, this book represents the largest compilation of timeline events associated with Pharmacogenomics when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Pharmacogenomics, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.

Pharmacogenomics in Admixed Populations

by: Guilherme Suarez-kurtz
publisher: Landes Bioscience, published: 2007-08-01
ASIN: 1587063115
EAN: 9781587063114
sales rank: 5426348

Pharmacogenomic: Webster's Timeline History, 1997 - 2007

by: Icon Group International
publisher: ICON Group International, Inc., published: 2010-08-17
ASIN: B0063ILDCC
Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Pharmacogenomic," including when used in literature (e.g. all authors that might have Pharmacogenomic in their name). As such, this book represents the largest compilation of timeline events associated with Pharmacogenomic when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Pharmacogenomic, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.

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	An A-Z Guide to Pharmacogenomics by: Michael G. Catania publisher: American Association for Clinical Chemistry, published: 2006-07-14 ASIN: 1594250472 EAN: 9781594250477 sales rank: 2547448 Pharmacogenomics and the concept of customizable, personalized medicine promise to change how physicians treat disease and how drug companies develop and market drugs. Intended for scientists and physicians who have a basic understanding of molecular biology, An A-Z Guide to Pharmacogenomics introduces the terms and techniques common to this fast-paced and high-stakes field and explains them in a straightforward, easy-to-understand way. The impact of pharmacogenomics on medicine will be revolutionary, drawing together a diverse group of scientific disciplines and impacting everything from basic research to the patient's hospital bedside. The terms listed in this A to Z guide reflect this diversity of scope, representing basic biology, bioinformatics, diagnostics, and drug discovery. The pharmacogenomics revolution has already begun -- the FDA recently approved the first genetic test designed to predict an individual's response to a given drug. This guide is a starting point for anyone interested in the technology that will revolutionize medicine and directly impact the health and well-being of millions of people.
	Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory (Molecular and Translational Medicine) publisher: Humana Press, published: 2011-02-17 ASIN: 1607612828 EAN: 9781607612827 sales rank: 2681991 While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field.
	Pharmacogenomics: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-19 ASIN: 1617375713 EAN: 9781617375712 sales rank: 5141230 Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
	Lexi-Comp's Pharmacogenomics Handbook by: Larisa M. Humma publisher: Lexi Comp, published: 2003-07 ASIN: 1591950600 EAN: 9781591950608 sales rank: 5873937 Presents information concerning key genetic variations that may influence drug disposition &/or sensitivity...sections included: intoduction to pharmacogenomics, intro to genetics, polymorphism monographs, definitions/glossary & much more.
	Pharmacogenomics: Social, Ethical, and Clinical Dimensions publisher: Wiley-Liss, published: 2003-01-23 ASIN: 0471227692 EAN: 9780471227694 sales rank: 2945067 Through analyses of the complex underlying issues, this interdisciplinary volume frames the agenda for dealing with genetic variation and incorporating pharmacogenomics into health care. The three sections of this book, Research Issues, Clinical Issues, and Social Perspectives address key elements integral to a comprehensive discussion of this emerging field. This groundbreaking text… Examines new research strategies, methodologies, and ethical and social considerations of pharmacogenomics Addresses practical considerations of anticipated changes in education, training, oversight, guidelines and protocols, and continuing education requirements Provides analyses of the potential enormous impact of pharmacogenomics, such as in the standard of care and treatment, including perspectives from the fields of anthropology, law, ethics, and economics
	Referenced Review Questions in Pharmacogenomics by: Robert M. White publisher: AACC Press, published: 2007-07-31 ASIN: 1594250707 EAN: 9781594250705 sales rank: 3010609 The application of pharmacogenomic principles to medication use is beginning to radically change the way drugs are selected and monitored. Those who wish to evaluate their knowledge in the basics of the subject and in applications such as drug selection and drug avoidance will therefore find Referenced Review Questions in Pharmacogenomics an invaluable guide to this rapidly evolving field. The book features three sections: Questions Answers and Explanation References (provided as a basis for the answers and to encourage the reader to review the references and expand his/her knowledge or area of expertise) The Questions section is further subdivided into the following topics: The Basics; Cytochrome P450s and Other Enzymes; Receptors; N-Acetyl Transferases; Asthma and Other Pulmonary Diseases; Neurology; Antimicrobials and Infectious Disease; Immunology; Oncology; Analgesics, Sedatives, Hypnotics, and Anesthetics; Psychiatry; Antiinflammatory Drugs; Oral Hypoglycemics; Glucose-6-phosphate Dehydrogenase; Anticoagulants; Inflammatory Bowel Disease and Other Gastrointestinal Drugs; Bone and Mineral Metabolism; and Cardiovascular Drugs. A large portion of the specific information on individual drugs is derived from the pharmaceutical industry, which performs the majority of the pharmacogenomics testing as part of pre-market approval. Because the emerging concept of personalized medicine is placing significant demands on physicians and on pharmacists in particular, they-as well as academic and practicing clinical chemists and pathologists who have an interest in pharmacogenomics-will find Referenced Review Questions in Pharmacogenomics especially useful. Technologists and other healthcare professionals who have an interest in molecular medicine and who would like to broaden their professional horizons will also find this text enlightening.
	Pharmacogenomics and Proteomics: Enabling the Practice of Personalized Medicine by: Steven H. Y. Wong publisher: AACC Press, published: 2006-05-01 ASIN: 1594250464 EAN: 9781594250460 sales rank: 3153731 The new "molecular economy," fundamentally driven by understanding molecules and their interactions, has spawned an exciting discipline referred to as "clinical" pharmacogenomics or pharmacogenetics. Combining this discipline with our knowledge of protein function and regulation (proteomics), a more complete understanding of systems physiology is achieved-giving rise to a "systems biology" perspective. From this new perspective, the practice of medicine is becoming more dependent on the application of biomarkers-genomics, proteomics, and other functional biomarkers-toward personalized medicine, thus allowing a practical convergence to optimize matching of the right patient and the right diagnosis with the right drug and the right dose at the right time. To enable the practice of personalized medicine with an understanding of pharmacogenomics and proteomics, this book reviews: the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis; methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics; specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice. As the new molecular economy emerges, this text provides the basic pharmacogenomic and proteomic tools needed to understand this new, rapidly evolving, and exciting discipline.
	Pharmacogenomics: Webster's Timeline History, 1997 - 2007 by: Icon Group International publisher: ICON Group International, Inc., published: 2009-06-06 ASIN: 0546891543 EAN: 9780546891546 sales rank: 5019124 Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Pharmacogenomics," including when used in literature (e.g. all authors that might have Pharmacogenomics in their name). As such, this book represents the largest compilation of timeline events associated with Pharmacogenomics when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Pharmacogenomics, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.
	Pharmacogenomics in Admixed Populations by: Guilherme Suarez-kurtz publisher: Landes Bioscience, published: 2007-08-01 ASIN: 1587063115 EAN: 9781587063114 sales rank: 5426348
	Pharmacogenomic: Webster's Timeline History, 1997 - 2007 by: Icon Group International publisher: ICON Group International, Inc., published: 2010-08-17 ASIN: B0063ILDCC Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Pharmacogenomic," including when used in literature (e.g. all authors that might have Pharmacogenomic in their name). As such, this book represents the largest compilation of timeline events associated with Pharmacogenomic when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Pharmacogenomic, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.