protein-phosphorylation books

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The Ten Most Wanted Solutions in Protein Bioinformatics (Chapman & Hall/CRC Mathematical & Computational Biology)

by: Anna Tramontano
publisher: Chapman and Hall/CRC, published: 2005-05-24
ASIN: 1584884916
EAN: 9781584884910
sales rank: 761531
Utilizing high speed computational methods to extrapolate to the rest of the protein universe, the knowledge accumulated on a subset of examples, protein bioinformatics seeks to accomplish what was impossible before its invention, namely the assignment of functions or functional hypotheses for all known proteins.

The Ten Most Wanted Solutions in Protein Bioinformatics considers the ten most significant problems occupying those looking to identify the biological properties and functional roles of proteins.

- Problem One considers the challenge involved with detecting the existence of an evolutionary relationship between proteins.
- Two and Three studies the detection of local similarities between protein sequences and analysis in order to determine functional assignment.
- Four, Five, and Six look at how the knowledge of the three-dimensional structures of proteins can be experimentally determined or inferred, and then exploited to understand the role of a protein.
- Seven and Eight explore how proteins interact with each other and with ligands, both physically and logically.
- Nine moves us out of the realm of observation to discuss the possibility of designing completely new proteins tailored to specific tasks.
- And lastly, Problem Ten considers ways to modify the functional properties of proteins.

After summarizing each problem, the author looks at and evaluates the current approaches being utilized, before going on to consider some potential approaches.

The Proteomics Protocols Handbook

publisher: Humana Press, published: 2005-03-09
ASIN: 1588295931
EAN: 9781588295934
sales rank: 1080955
Hands-on researchers describe in step-by-step detail 73 proven laboratory methods and bioinformatics tools essential for analysis of the proteome. These cutting-edge techniques address such important tasks as sample preparation, 2D-PAGE, gel staining, mass spectrometry, and post-translational modification. There are also readily reproducible methods for protein expression profiling, identifying protein-protein interactions, and protein chip technology, as well as a range of newly developed methodologies for determining the structure and function of a protein. The bioinformatics tools include those for analyzing 2D-GEL patterns, protein modeling, and protein identification. All laboratory-based protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Protein Phosphatases (Topics in Current Genetics)

publisher: Springer, published: 2010-12-01
ASIN: 3642058175
EAN: 9783642058172
sales rank: 7867745
This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes. The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.

Proteins: Biotechnology and Biochemistry

by: Gary Walsh
publisher: Wiley, published: 2001-12-13
ASIN: 0471899070
EAN: 9780471899075
sales rank: 1410016
Protein Biotechnology and Biochemistry is a complete and definitive source of information for all those interested in the area, providing a broad overview of the various medical, diagnostic and industrial uses of proteins. It covers basic biochemical principles as well as providing a comprehensive survey of products currently available or under development.
* The new edition has been thoroughly updated with new material.
* The key difference is that this new edition will include more "pure" biochemistry.
* There are two completely new chapters: Protein Structure - an overview and Novel Proteins from Novel Sources.
Chapter 2, Protein Structure, an overview and chapter 3, Protein Purification & Characterisation, make up approximately 30% of the book. These chapters concentrate on the basic biochemical principles of proteins and will lay the foundations for the rest of the book. The remaining chapters focus on protein biotechnology and have been rearranged, updated and expanded.

Protein Trafficking in Neurons

publisher: Academic Press, published: 2006-11-02
ASIN: 012369437X
EAN: 9780123694379
sales rank: 1587148
The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases.

· Provides a comprehensive examination of membrane/protein movement in neuronal function.
· Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease
· Includes a focus on Molecular Mechanisms
· Illustrated with color summary pictures
· The only book examining protein trafficking and its functional implications, written by leaders in the field

Post-translational Modification of Protein Biopharmaceuticals

publisher: Wiley-VCH, published: 2009-09-01
ASIN: 3527320741
EAN: 9783527320745
sales rank: 1521923
From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering.
This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals.

Protein Phosphorylation in Plants (Proceedings of the Phytochemical Society of Europe)

publisher: Oxford University Press, USA, published: 1996-07-11
ASIN: 019857777X
EAN: 9780198577775
sales rank: 10291837
Protein phosphorylation and dephosphorylation play key roles in many aspects of plant growth, including control of cell division, pathways of carbon and nitrogen metabolism, and signal transduction. This book is the first attempt to cover all aspects of this rapidly expanding area of research in a single volume. It includes work from key groups at the forefront of research in this area, with studies at the biochemical, molecular, and cell biological levels.

Protein Phosphorylation: A Practical Approach (Practical Approach Series)

publisher: Oxford University Press, USA, published: 1993-06-03
ASIN: 0199633053
EAN: 9780199633050
sales rank: 8492524
Reversible phosphorylation is one of the major mechanisms by which protein activity is controlled in all eukaryotic cells. Networks of protein kinases and phosphatases, which catalyze phosphorylation and dephosphorylation respectively, are responsible for switching between different pathways of cell division, development, or differentiation in response to hormones or growth factors. This book provides a comprehensive description of current methods for studying protein phosphorylation and the protein kinases and phosphatases which catalyze it. It includes detailed protocols for studying phosphorylation in intact cells, approaches using enzyme inhibitors, purification of serine/threonine-specific protein kinases/phosphatases, analysis of kinase/phosphatase specificity, and cloning relevant cDNAs. Protein Phosphorylation: A Practical Approach will be of great value to all researchers in the fields of intracellular and intercellular signalling, including biochemists, molecular biologists and pharmacologists.

Signal Transduction and Protein Phosphorylation (Nato Science Series: A:)

publisher: Springer, published: 1987-12-01
ASIN: 0306426153
EAN: 9780306426155

Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease

publisher: Springer, published: 1994-11-30
ASIN: 0306448149
EAN: 9780306448140
sales rank: 11330943
Royal Academy of Sciences of Spain, Madrid. Proceedings of a symposium held July 5-9, 1994, in El Escorial, Spain. Advanced cell biology research. 74 contributors, 7 U.S.

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	The Ten Most Wanted Solutions in Protein Bioinformatics (Chapman & Hall/CRC Mathematical & Computational Biology) by: Anna Tramontano publisher: Chapman and Hall/CRC, published: 2005-05-24 ASIN: 1584884916 EAN: 9781584884910 sales rank: 761531 Utilizing high speed computational methods to extrapolate to the rest of the protein universe, the knowledge accumulated on a subset of examples, protein bioinformatics seeks to accomplish what was impossible before its invention, namely the assignment of functions or functional hypotheses for all known proteins. The Ten Most Wanted Solutions in Protein Bioinformatics considers the ten most significant problems occupying those looking to identify the biological properties and functional roles of proteins. - Problem One considers the challenge involved with detecting the existence of an evolutionary relationship between proteins. - Two and Three studies the detection of local similarities between protein sequences and analysis in order to determine functional assignment. - Four, Five, and Six look at how the knowledge of the three-dimensional structures of proteins can be experimentally determined or inferred, and then exploited to understand the role of a protein. - Seven and Eight explore how proteins interact with each other and with ligands, both physically and logically. - Nine moves us out of the realm of observation to discuss the possibility of designing completely new proteins tailored to specific tasks. - And lastly, Problem Ten considers ways to modify the functional properties of proteins. After summarizing each problem, the author looks at and evaluates the current approaches being utilized, before going on to consider some potential approaches.
	The Proteomics Protocols Handbook publisher: Humana Press, published: 2005-03-09 ASIN: 1588295931 EAN: 9781588295934 sales rank: 1080955 Hands-on researchers describe in step-by-step detail 73 proven laboratory methods and bioinformatics tools essential for analysis of the proteome. These cutting-edge techniques address such important tasks as sample preparation, 2D-PAGE, gel staining, mass spectrometry, and post-translational modification. There are also readily reproducible methods for protein expression profiling, identifying protein-protein interactions, and protein chip technology, as well as a range of newly developed methodologies for determining the structure and function of a protein. The bioinformatics tools include those for analyzing 2D-GEL patterns, protein modeling, and protein identification. All laboratory-based protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
	Protein Phosphatases (Topics in Current Genetics) publisher: Springer, published: 2010-12-01 ASIN: 3642058175 EAN: 9783642058172 sales rank: 7867745 This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes. The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.
	Proteins: Biotechnology and Biochemistry by: Gary Walsh publisher: Wiley, published: 2001-12-13 ASIN: 0471899070 EAN: 9780471899075 sales rank: 1410016 Protein Biotechnology and Biochemistry is a complete and definitive source of information for all those interested in the area, providing a broad overview of the various medical, diagnostic and industrial uses of proteins. It covers basic biochemical principles as well as providing a comprehensive survey of products currently available or under development. * The new edition has been thoroughly updated with new material. * The key difference is that this new edition will include more "pure" biochemistry. * There are two completely new chapters: Protein Structure - an overview and Novel Proteins from Novel Sources. Chapter 2, Protein Structure, an overview and chapter 3, Protein Purification & Characterisation, make up approximately 30% of the book. These chapters concentrate on the basic biochemical principles of proteins and will lay the foundations for the rest of the book. The remaining chapters focus on protein biotechnology and have been rearranged, updated and expanded.
	Protein Trafficking in Neurons publisher: Academic Press, published: 2006-11-02 ASIN: 012369437X EAN: 9780123694379 sales rank: 1587148 The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. · Provides a comprehensive examination of membrane/protein movement in neuronal function. · Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease · Includes a focus on Molecular Mechanisms · Illustrated with color summary pictures · The only book examining protein trafficking and its functional implications, written by leaders in the field
	Post-translational Modification of Protein Biopharmaceuticals publisher: Wiley-VCH, published: 2009-09-01 ASIN: 3527320741 EAN: 9783527320745 sales rank: 1521923 From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering. This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals.
	Protein Phosphorylation in Plants (Proceedings of the Phytochemical Society of Europe) publisher: Oxford University Press, USA, published: 1996-07-11 ASIN: 019857777X EAN: 9780198577775 sales rank: 10291837 Protein phosphorylation and dephosphorylation play key roles in many aspects of plant growth, including control of cell division, pathways of carbon and nitrogen metabolism, and signal transduction. This book is the first attempt to cover all aspects of this rapidly expanding area of research in a single volume. It includes work from key groups at the forefront of research in this area, with studies at the biochemical, molecular, and cell biological levels.
	Protein Phosphorylation: A Practical Approach (Practical Approach Series) publisher: Oxford University Press, USA, published: 1993-06-03 ASIN: 0199633053 EAN: 9780199633050 sales rank: 8492524 Reversible phosphorylation is one of the major mechanisms by which protein activity is controlled in all eukaryotic cells. Networks of protein kinases and phosphatases, which catalyze phosphorylation and dephosphorylation respectively, are responsible for switching between different pathways of cell division, development, or differentiation in response to hormones or growth factors. This book provides a comprehensive description of current methods for studying protein phosphorylation and the protein kinases and phosphatases which catalyze it. It includes detailed protocols for studying phosphorylation in intact cells, approaches using enzyme inhibitors, purification of serine/threonine-specific protein kinases/phosphatases, analysis of kinase/phosphatase specificity, and cloning relevant cDNAs. Protein Phosphorylation: A Practical Approach will be of great value to all researchers in the fields of intracellular and intercellular signalling, including biochemists, molecular biologists and pharmacologists.
	Signal Transduction and Protein Phosphorylation (Nato Science Series: A:) publisher: Springer, published: 1987-12-01 ASIN: 0306426153 EAN: 9780306426155
	Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease publisher: Springer, published: 1994-11-30 ASIN: 0306448149 EAN: 9780306448140 sales rank: 11330943 Royal Academy of Sciences of Spain, Madrid. Proceedings of a symposium held July 5-9, 1994, in El Escorial, Spain. Advanced cell biology research. 74 contributors, 7 U.S.