Life science and biomedical books

Related books on 'protein-structure'

	Membrane Protein Structure: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2012-08-31 ASIN: 1627030220 EAN: 9781627030229 Membrane proteins play key roles in numerous cellular processes, in particular mediating cell-to-cell communication and signaling events that lead to a multitude of biological effects. Membrane proteins have also been implicated in many critical diseases such as atherosclerosis, hypertension, diabetes and cancer. In Membrane Protein Structure Predictions Methods: Methods and Protocols, expert researcher in the field detail the advances in both experimental and computational approaches of the structure, dynamics and interactions of membrane proteins dividing the volume into two sections. The first section details the procedures used for measurements of structure and dynamics of membrane proteins. While the second section contains a survey of the computational methods that have played a critical role in membrane protein structure prediction as well as in providing atomic level insight into the mechanism of the dynamics of membrane receptors. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Membrane Protein Structure Predicitons: Methods and Protocols seeks to aid scientists in the further study of membrane protein structure and function.
	Protein Structure Prediction (Methods in Molecular Biology) publisher: Humana Press, published: 2010-11-19 ASIN: 1617377570 EAN: 9781617377570 sales rank: 3329181 This book covers elements of both the data-driven comparative modeling approach to structure prediction and also recent attempts to simulate folding using explicit or simplified models. Despite the unsolved mystery of how a protein folds, advances are being made in predicting the interactions of proteins with other molecules. Also rapidly advancing are the methods for solving the inverse folding problem, the problem of finding a sequence to fit a structure. This book focuses on the various computational methods for prediction, their successes and their limitations, from the perspective of their most well known practitioners.
	Computational Methods for Protein Structure Prediction and Modeling: Volume 1: Basic Characterization (Biological and Medical Physics, Biomedical Engineering) publisher: Springer, published: 2010-11-29 ASIN: 1441922059 EAN: 9781441922052 sales rank: 3518676 Volume One of this two-volume sequence focuses on the basic characterization of known protein structures, and structure prediction from protein sequence information. Eleven chapters survey of the field, covering key topics in modeling, force fields, classification, computational methods, and structure prediction. Each chapter is a self contained review covering definition of the problem and historical perspective; mathematical formulation; computational methods and algorithms; performance results; existing software; strengths, pitfalls, challenges, and future research.
	Intrinsically Disordered Protein Analysis: Volume 2, Methods and Experimental Tools (Methods in Molecular Biology) publisher: Springer, published: 2012-07-31 ASIN: 1461437032 EAN: 9781461437031 Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 2 includes sections on single molecule techniques, methods to assess protein size and shape, analyzing conformational behavior, mass-spectrometry, expression and purification of IDP’s. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.   Thorough and intuitive, Intrinsically Disordered Protein Analysis: Methods and Experimental Tools helps scientists further their investigations of these fascinating and dynamic molecules.
	Proteases: Structure and Function publisher: Springer, published: 2012-12-29 ASIN: 3709108845 EAN: 9783709108840 sales rank: 5769584 Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.
	Advances in Chemical Physics, Proteins: A Theoretical Perspective of Dynamics, Structure, and Thermodynamics by: Charles L. Brooks publisher: Wiley-Interscience, published: 1990-06-21 ASIN: 047152977X EAN: 9780471529774 sales rank: 1548118 Presenting a wide-ranging view of current developments in protein research, the papers in this collection, each written by highly regarded experts in the field, examine various aspects of protein structure, functions, dynamics, and experimentation. Topics include dynamical simulation methods, the biological role of atom fluctuations, protein folding, influences on protein dynamics, and a variety of analytical techniques, such as X-ray diffraction, vibrational spectroscopy, photodissociation and rebinding kinetics. This is part of a series devoted to providing general information on a wide variety of topics in chemical physics in order to stimulate new research and to serve as a text for beginners in a particular area of chemical physics.
	Principles of Protein Structure (Springer Advanced Texts in Chemistry) by: G.E. Schulz publisher: Springer, published: 1979-04-05 ASIN: 0387903348 EAN: 9780387903347 sales rank: 1953216 There has been an explosion in the information available about protein structure. "Principles of Protein Structure" provides a comprehensive overview of this massive set of information. The authors use the known structures to illustrate the forces which determine protein structures, the rationale behind many of the features of organization of proteins, and the mechanisms by which proteins perform biological functions. This textbook surveys not only what is known, but also how the structural data can be organized and systematized and what it can be used for in chemical and biomedical research. The book includes what is probably the most comprehensive published bibliography on protein structure.
	Protein Structure: A Practical Approach publisher: Oxford University Press, USA, published: 1997-04-15 ASIN: 0199636184 EAN: 9780199636181 sales rank: 265717 Protein Structure: A Practical Approach gives general methods for determining protein structure that will be very widely applicable, from the simple electrophoretic, chromatographic, and spectrophotometric techniques to the relatively more complex and sophisticated methods of mass spectrometry and ultracentrifugation. This second edition has been fully updated to embrace the most recent developments in the field, and will be invaluable to all involved in protein research.
	Chemistry: Structure and Dynamics by: James N. Spencer publisher: Wiley, published: 2010-12-28 ASIN: 0470587113 EAN: 9780470587119 sales rank: 42965 The Spencer text is the only text that is built on independently researched pedagogy on the best way to teach General Chemistry. Chemistry: Structure and Dynamics, 5th Edition emphasises deep understanding rather than comprehensive coverage along with a focus on the development of inquiry and reasoning skills. While most mainstream General Chemistry texts offer a breadth of content coverage, the Spencer author team, in contrast, focuses on depth and student preparation for future studies. The fifth edition is revised in keeping with our commitment to the chemical education community and specifically the POGIL (Process Oriented Guided Inquiry Learning) Project. This text reflects two core principles, first that the concepts that are covered are fundamental building blocks for understanding chemistry and second, that the concepts should be perceived by the students as being directly applicable to their interests and careers. The authors further provide this "core" coverage using 1 of 3 models; data-driven, chemical theories and students understanding, which allows for a more concrete foundation on which students build conceptual understanding.
	Introduction to Protein Structure Prediction: Methods and Algorithms (Wiley Series in Bioinformatics) publisher: Wiley, published: 2010-12-28 ASIN: 0470470593 EAN: 9780470470596 sales rank: 2590755 A look at the methods and algorithms used to predict protein structure A thorough knowledge of the function and structure of proteins is critical for the advancement of biology and the life sciences as well as the development of better drugs, higher-yield crops, and even synthetic bio-fuels. To that end, this reference sheds light on the methods used for protein structure prediction and reveals the key applications of modeled structures. This indispensable book covers the applications of modeled protein structures and unravels the relationship between pure sequence information and three-dimensional structure, which continues to be one of the greatest challenges in molecular biology. With this resource, readers will find an all-encompassing examination of the problems, methods, tools, servers, databases, and applications of protein structure prediction and they will acquire unique insight into the future applications of the modeled protein structures. The book begins with a thorough introduction to the protein structure prediction problem and is divided into four themes: a background on structure prediction, the prediction of structural elements, tertiary structure prediction, and functional insights. Within those four sections, the following topics are covered: Databases and resources that are commonly used for protein structure prediction The structure prediction flagship assessment (CASP) and the protein structure initiative (PSI) Definitions of recurring substructures and the computational approaches used for solving sequence problems Difficulties with contact map prediction and how sophisticated machine learning methods can solve those problems Structure prediction methods that rely on homology modeling, threading, and fragment assembly Hybrid methods that achieve high-resolution protein structures Parts of the protein structure that may be conserved and used to interact with other biomolecules How the loop prediction problem can be used for refinement of the modeled structures The computational model that detects the differences between protein structure and its modeled mutant Whether working in the field of bioinformatics or molecular biology research or taking courses in protein modeling, readers will find the content in this book invaluable.

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