Related books on 'structural-biology'
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by: Bruce R. Donald publisher: The MIT Press, published: 2011-06-01 ASIN: 0262015595 EAN: 9780262015592 sales rank: 1672081 Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field. |
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by: Anders Liljas publisher: World Scientific Publishing Company, published: 2009-02-04 ASIN: 9812772081 EAN: 9789812772084 sales rank: 1288155 This is an important textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. Written by a team of leading scientists in the field, it covers all the essential aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution -- the comparative structural biology. The focus is on interesting and relevant molecular structures as well as central biology. This comprehensive volume is richly illustrated with more than 200 color figures. So far, there has been a lack of comprehensive textbooks on structural biology that are up to date; this book is written to fill the gap. An accompanying CD contains high-resolution images that can be projected in a classroom. Contents: Introduction; Basics of Protein Structure; Basics of Nucleic Acid Structure; The Basics of Lipids and Membrane Structure; Enzymes; Metabolism of DNA: Replication and Recombination; Transcription; Protein Synthesis Translation; Protein Folding and Degradation; Membrane Proteins; Signal Transduction; Cell Motility and Transport; Structural Aspects of Cell Cell Interactions; The Immune System; Virus Structure and Function; Structural Biology and the Evolution of Biomacromolecules; Appendices: Bonds and Energetics of Macromolecules; Methods for Fold Comparison; Prediction of Protein Conformation; Assignment of Function to Proteins; Protein Modification; Nobel Laureates. |
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by: Gordon S. Rule publisher: Springer, published: 2005-12-19 ASIN: 1402034997 EAN: 9781402034992 sales rank: 250071 NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator. |
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by: Bill Shipley publisher: Cambridge University Press, published: 2002-09-02 ASIN: 0521529212 EAN: 9780521529211 sales rank: 843281 Bill Shipley explores the logical and methodological relationships between correlation and causation. He presents a series of statistical methods that can test, and potentially discover, cause-effect relationships between variables in situations where it is not possible to conduct randomized, or experimentally controlled, studies. Many of these methods are quite new and most are generally unknown to biologists. Besides describing how to conduct these statistical tests, he also puts the methods into historical context and explains when they can and cannot justifiably be used to test causal claims. Hb ISBN (2000); 0-521-79153-7 |
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by: Julian Vincent publisher: Princeton University Press, published: 2012-07-29 ASIN: 0691154007 EAN: 9780691154008 sales rank: 2209125 This is a thoroughly revised, updated, and expanded edition of a classic illustrated introduction to the structural materials in natural organisms and what we can learn from them to improve man-made technolog---from nanotechnology to textiles to architecture. Julian Vincent's book has long been recognized as a standard work on the engineering design of biomaterials and is used by undergraduates, graduates, researchers, and professionals studying biology, zoology, engineering, and biologically inspired design. This third edition incorporates new developments in the field, the most important of which have been at the molecular level. All of the illustrations have been redrawn, the references have been updated, and a new chapter on biomimetic design has been added. Vincent emphasizes the mechanical properties of structural biomaterials, their contribution to the lives of organisms, and how these materials differ from man-made ones. He shows how the properties of biomaterials are derived from their chemistry and interactions, and how to measure them. Starting with proteins and polysaccharides, he shows how skin and hair function, how materials self-assemble, and how ceramics such as bone and mother-of-pearl can be so stiff and tough, despite being made in water in benign ambient conditions. Finally, he combines these topics with an analysis of how the design of biomaterials can be adapted in technology, and presents a series of guidelines for designers.
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publisher: Springer, published: 2010-12-16 ASIN: 9048181275 EAN: 9789048181278 The worldwide increasing age of populations brought the neurodegenerative diseases into the focus of interest. A number of the diverse human neurodegenerative diseases are now recognized as conformational diseases frequently caused by aggregations of unfolded or misfolded proteins. Knowledge on the intrinsically unstructured proteins, a new family of gene products as well as on the misfolded proteins produced by genetic mutation or environmental effects has been extensively accumulated in the past years. These proteins frequently cause proteolytic stress and/ or enter into aberrant, non-physiological protein-protein interactions leading to sequestration of protein aggregates which are assemblies of many not-yet-identified components in addition to the deposition of well-characterized misfolded peptides and proteins such as b-amyloid, tau, a-synuclein and polyglutamine containing proteins. These protein assemblies display diverse ultrastructures such aggresomes, fibers, oligomers or amorphous structures, however, the nature of these species concerning their cytoprotective or cytotoxic effects has not been clarified yet. The main focus of this volume is to review the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, with special emphasis on the macromolecular homo- and heteroassociations of the malfolded proteins into characteristic ultrastructures found primarily in Parkinson’s and Alzheimer’s diseases. This book reviews the structural knowledge accumulated for well-studied and for newly discovered proteins involved in paradigmatic conformational disorders with the aim to broaden our understanding of the pathomechanisms of neurodegeneration, which is crucial for finding effective therapeutic interventions that could prevent or circumvent the development of neurodegenerative disorders in humans. |
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by: Stephen R. Bolsover publisher: Wiley-Blackwell, published: 2011-05-31 ASIN: 0470526998 EAN: 9780470526996 sales rank: 165893 This text tells the story of cells as the units of life in a colorful and student-friendly manner, taking an "essentials only" approach. By using the successful model of previously published "Short Courses," this text succeeds in conveying the key points without overburdening the reader with secondary information. The authors (all active researchers and educators) skillfully present concepts by illustrating them with clear diagrams and examples from current research. Special boxed sections focus on the importance of cell biology in medicine and industry today. This text is completely updated from the successful "Cell Biology, A Short Course, 2e," includes new chapters and now has a supporting website with tests and animations for students and power point slides and supplemental material for instructors. |
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publisher: Academic Press, published: 2011-09-12 ASIN: 0123864836 EAN: 9780123864833 sales rank: 1160625 Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation. Covers reviews of methodology and research in all aspects of protein chemistry. Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. |
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by: Stephen P. Ellner publisher: Princeton University Press, published: 2006-03-27 ASIN: 0691125899 EAN: 9780691125893 sales rank: 234602 From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering. |
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by: Royal Society of Chemistry publisher: Royal Society of Chemistry, published: 2007-11-19 ASIN: 0854043659 EAN: 9780854043651 sales rank: 945084 Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials. This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: A rich understanding of modern approaches to docking; A comparison and critical evaluation of state-of-the-art methods; Details on harnessing computational methods for both analysis and prediction; An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms; Critical reviews of current fragment based methods with perceptive applications to kinases. Addressing a wide range of uses of protein structures for drug discovery the Editors have created an essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery. |