Related books on 'transcriptional-regulation'
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by: John F. Atkins publisher: Cold Spring Harbor Laboratory Press, published: 2010-09-24 ASIN: 0879699469 EAN: 9780879699468 sales rank: 312479 Once thought to be just a messenger that allows genetic information encoded in DNA to direct the formation of proteins, RNA (ribonucleic acid) is now known to be a highly versatile molecule that has multiple roles in cells. It can function as an enzyme, scaffold various subcellular structures, and regulate gene expression through a variety of mechanisms, as well as act as a key component of the protein synthesis and splicing machinery. Perhaps most interestingly, increasing evidence indicates that RNA preceded DNA as the hereditary material and played a crucial role in the early evolution of life on Earth. This volume reviews our understanding of two RNA worlds: the primordial RNA world before DNA, in which RNA was both information store and biocatalyst; and the contemporary RNA world, in which mRNA, tRNA, rRNA, siRNA, miRNA, and a host of other RNAs operate. The early chapters of the book analyze the role of RNA in the first life forms and the appearance of cells. Subsequent chapters examine riboswitches and ribozymes, establishing what the RNA molecule is capable of alone. The book goes on to discuss the evolution of ribosomes and the functions of RNPs, before reviewing the recent work that has revolutionized our understanding of gene regulation by non-coding RNAs, including miRNAs and siRNAs. Also covered are viral RNAs, telomerase RNA, and tools for scientists who work on RNA. The book is thus essential reading for all molecular biologists and biochemists, as well as chemists interested in RNA technology, information storage, or enzyme catalysis. |
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publisher: Cold Spring Harbor Laboratory Press, published: 1993-01 ASIN: 0879694254 EAN: 9780879694258 sales rank: 10363165 The transcription of DNA into RNA lies at the heart of gene activation. It is a process tightly controlled by complex interactions between intracellular proteins and the DNA. This book is a landmark account of these controls, derived from the work of over 40 leading laboratories worldwide. It is intended as a definitive reference work for this evolving field. |
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by: Editors: Joyce A. DeLeo publisher: Intl Assoc for the Study of Pain, published: 2007-11-16 ASIN: 0931092671 EAN: 9780931092671 sales rank: 1292463 - Includes CD-ROM - An up-to-date review of the role of immune and glial factors in pain etiology - Immune-pain interactions in peripheral tissues and the central nervous system - The role of cytokines in neuropathic pain - Morphine tolerance and glial-pain interactions - New immune and glial targets for clinical pain control |
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publisher: Springer, published: 2001-02-15 ASIN: 3540676112 EAN: 9783540676119 sales rank: 8583064 Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide. |
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publisher: Springer, published: 2010-12-09 ASIN: 3642087094 EAN: 9783642087097 Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide. |
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publisher: Humana Press, published: 2007-12-14 ASIN: 1588297837 EAN: 9781588297839 sales rank: 1964730 This volume strives to present current technical approaches to most aspects of post-transcriptional control and provide the reader with a useful and versatile laboratory bench resource. With chapters split into sections covering bioinformatics, fundamental aspects of the study of RNA biology, and techniques for specific aspects of RNA biology, the expert authors have filled the book with invaluable tricks of the trade, perfected in their laboratories. |
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by: Panagiotis A. Tsonis publisher: Cambridge University Press, published: 2003-01-13 ASIN: 0521804744 EAN: 9780521804745 sales rank: 673130 Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level. Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three dimensional form. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death. This concise and unique synthesis and its accompanying web site offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states. |
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publisher: Portfolio Publishing Co Inc.,U.S., published: 1990-11 ASIN: 0943255112 EAN: 9780943255118 sales rank: 6228175 |
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by: Mark Ptashne and Alexander Gann publisher: Cold Spring Harbor Laboratory Press, published: 2001-11-13 ASIN: 0879696338 EAN: 9780879696337 sales rank: 223790 Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types. |
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publisher: Springer, published: 2010-11-29 ASIN: 3642080189 EAN: 9783642080180 sales rank: 705381 This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives. |