Related books on 'tumor-suppressor-gene oncogene'
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by: Robin Hesketh publisher: Academic Press, published: 1997-08-06 ASIN: 0123445485 EAN: 9780123445483 sales rank: 5411250 The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. Key Features * Includes much new data on this fast-moving field, including newly discovered oncogenes * Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes * Contains more than 2000 terms for reference and further research * Revised to included signaling pathways, apoptosis, and metastasis |
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publisher: Marcel Dekker, published: 1998-11-15 ASIN: 0824701607 EAN: 9780824701604 sales rank: 1245793 This thoroughly up-to-date reference addresses new approaches to the diagnosis, management, and treatment of lung tumors, providing the insights of fundamental biologists, surgical pathologists, and clinicians. Featuring research from over 75 internationally recognized experts in the field, Lung Tumors · details the key factors of lung tumor carcinogenesis · analyzes multimodality treatments using chemotherapy and fractionated radiotherapy · reviews telomerase activation as well as the p53 and Rb pathways · investigates the FHIT gene and gene hypermethylation · elucidates the complex relationship between host and tumor · highlights angiogenesis and the clonal evolution of preneoplastic lesions · profiles the differential diagnosis between primary and secondary tumors · examines the rare and borderline malignancies · and more! Containing nearly 3000 references, drawings, photographs, and micrographs, Lung Tumors serves as an excellent reference for pulmonologists and pulmonary disease specialists, physiologists, respiratory and thoracic surgeons, oncologists, pathologists and surgical pathologists, molecular and cellular biologists, lung radiologists, medical school and graduate students in these disciplines. |
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publisher: Springer, published: 2009-08-24 ASIN: 3642004741 EAN: 9783642004742 sales rank: 4267641 In the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication. |
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publisher: Springer, published: 2012-03-20 ASIN: 9400729561 EAN: 9789400729568 sales rank: 1714842 A general introduction to the principles of diagnosis and treatment of children with brain tumors is presented. Molecular characterization of solid tumors is also presented. Molecular pathways provide putative targets for new therapies. High resolution magic spinning NMR spectroscopy is explained, which is used to determine metabolic profiles for small pieces of intact tissue and whole cells in culture. The differences between adult and pediatric brain tumors are outlined. It is emphasized that pediatric low-grade gliomas need lower doses of antidrugs such as cisplatin/etoposide. It is explained that tumor suppressor genes and oncogenes play a crucial role in the development and progression of human malignancies, including those in children. Neurofibromatosis type-1 is a common genetic disorder with a high prevalence in CNS abnormalities including tumors in children; which is discussed in detail. Various neuroradiological imaging modalities in children with leukemia are detailed. Also are detailed results of clinical trials in pediatric brain tumors, such as medulloblastoma, ependymoma, craniopharyngioma, low-grade glioma, high-grade glioma, brainstem glioma, and germ cell tumors, using radiotherapy. Considering the clinical importance of epilepsy in the primary brain tumors in children, its symptoms, diagnosis, and treatments (surgery and antiepileptic drugs) are discussed. |
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publisher: Springer, published: 2009-10-27 ASIN: 0387980938 EAN: 9780387980935 sales rank: 2621616 Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer. |
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publisher: Springer, published: 2006-01-11 ASIN: 0387241353 EAN: 9780387241357 sales rank: 3205974 The p53 tumor suppressor gene is mutated in approximately half of all human malignancies, including colon, lung, and breast cancers. It is well recognized that these mutations directly inactivate p53 tumor suppressor function. Furthermore, the p53 protein operates within a pathway and this pathway, including the mutations in p53, is likely inactivated by nearly every human tumor. In support of this hypothesis, 100% of mice that have been engineered such that they do not express p53 protein (knockout animals), develop highly malignant tumors by only 3-6 months of age. The importance of p53 in preventing human cancer is also evident by families in which a mutated p53 gene is inherited from a parent. Individuals who carry an inherited germline p53 mutation are associated with Li-Fraumeni syndrome. These carriers often develop cancer as children or young adults (some have multiple tumors) and remarkably, 90% of these individuals will develop cancer by 60 years of age. Lastly, cigarette smoke, sexually transmitted viruses, and other environmental hazards play a significant role in the disruption of the p53 pathway. The p53 Tumor Suppressor Pathway and Cancer provides a comprehensive review of the p53 tumor suppressor pathway, how p53 functions to prevent tumor genesis, and how this pathway is corrupted during tumor development. The latest, state-of-the-art strategies to combat cancer by targeting p53 defects in tumors is also presented. |
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publisher: Churchill Livingstone, published: 2007-04-05 ASIN: 0443074348 EAN: 9780443074349 sales rank: 122442 Up to date and comprehensive, the New Edition of Fletcher's renowned Diagnostic Histopathology of Tumors provides you with today's best knowledge on the pathologic diagnosis of human tumors. This 3rd edition incorporates all of the latest ancillary diagnostic and prognostic techniques so you can effectively evaluate and confidently interpret suspected tumor specimens. Plus, more than 50 internationally recognized authorities and over 3,100 full-color illustrations provide you with an up-to-date account of tumor morphology, the application of modern diagnostic techniques (including molecular genetics), and key aspects of differential diagnosis.
With over 50 international contributing experts. |
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by: Steven Potter publisher: Random House, published: 2010-09-14 ASIN: 140006905X EAN: 9781400069057 sales rank: 1177064 This compelling new book covers the most important revolution since Darwin—how cutting-edge genetic science will soon allow us to speed up and transform our own evolution, and the moral choices we must make as we improve, alter, and even duplicate ourselves. The fact is that, until now, human evolution has been exceedingly slow. But there’s about to be a profound change in this process, with a perfect storm of revolutions in the fields of genetic modification, stem cells, DNA sequencing, and embryo manipulation. The result is that it will soon be possible for parents to consciously choose the genes of their children, defining their intelligence, appearance, athletic ability, and health. The ramifications could be enormous, with each generation smarter, more technologically proficient, and better able to design the genes of their offspring. Where will this evolution on steroids take us? Designer Genes presents a balanced view, describing the underlying science in accessible terms and discussing the pros and cons of implementing this new technology. A leading expert in the field, Steven Potter covers a broad range of topics on this challenging subject, presenting fascinating details of case histories and ongoing discoveries: • the true story of “Adam,” who as an early embryo was genetically selected to save his sickly sister • the surprising human genome—and DNA sequence comparisons across species • dogs, an informative example of human-driven evolution • the sequencing revolution, with the price of determining a person’s complete DNA sequence becoming much more affordable • genetic diseases and what is being discovered about them every day • stem cells and their almost magical powers Designer Genes also investigates such controversial questions as: When is an embryo a person? Are we smart enough to pick optimal gene combinations? What will the government’s role be? Science has brought us an astonishing understanding of the genetic basis of life, as well as potent new power to guide the genetic destiny of humanity. What will we do next? |
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by: Jeffre L. Witherly publisher: Cold Spring Harbor Laboratory Press, published: 2001-10-15 ASIN: 0879696001 EAN: 9780879696009 sales rank: 1401290 Medical science constantly demands our attention, as patients or relatives, concerned citizens, voters, investors, or simply curious individuals. But for those without training, the language of science is often hard to follow. The A to Z of DNA Science book series defines and illustrates specialized terms in ways that non-specialists can appreciate and enjoy. This volume focuses on the language of genes, genomes, DNA, biotechnology, and heredity, defining, explaining, and illustrating over 200 terms used in books, broadcasting, websites, and newspaper and magazine articles. |
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publisher: Humana Press, published: 2010-12-02 ASIN: 1607619679 EAN: 9781607619673 sales rank: 1442574 The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease. |