apoptosis books

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Apoptosis in Health and Disease: Clinical and Therapeutic Aspects

publisher: Cambridge University Press, published: 2012-01-26
ASIN: 052115944X
EAN: 9780521159449
sales rank: 4544298
The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.

Beyond Apoptosis: Cellular Outcomes of Cancer Therapy

publisher: INFRMA-HC, published: 2008-09-01
ASIN: 084939192X
EAN: 9780849391927
sales rank: 3556711

Apoptosis, the process of deliberate cell death within a multi-cellular organism, has been linked to both the development and the demise of cancer causing cells. Vast research has been conducted on combating cancer cells through apoptosis in radiation and chemotherapy, however, apoptosis plays only a limited role in determining the success of cancer therapy. This realization has been the catalyst necessary to examine alternative mechanisms for the anti-proliferative action of anticancer agents, as well as moving forward in the complete eradication of cancer. The goal of Beyond Apoptosis: Cellular Outcomes of Cancer Therapy is to examine the relative contribution of apoptosis, and to acquaint the readers with new concepts in non-apoptotic cell death, senescence, and mitotic catastrophe.

Apoptosis, Volume 322 (Methods in Enzymology)

publisher: Academic Press, published: 2000-07-19
ASIN: 0121822230
EAN: 9780121822231
sales rank: 3833635
Volume 322 of Methods in Enzymology is dedicated to apoptosis. Major topics covered include measuring apoptosis and apoptosis-induced endonucleases, measuring apoptosis in lower organisms, proteases involved in apoptosis and their inhibitors, cell free systems for monitoring steps in apoptosis pathways, mitochondria and apoptosis, bCl-2 family proteins, and studying receptors and signal transduction events implicated in cell survival and cell death.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Apoptosis: A Practical Approach (Practical Approach Series)

publisher: Oxford University Press, USA, published: 2000-03-09
ASIN: 0199637857
EAN: 9780199637850
sales rank: 4525535
This important text provides conceptual outlines and detailed procedures for basic and advanced studies of cell death by apoptis. Chapters on the recognition of apoptis as distinguished from neurosis and nonspecific cell DNA damage are followed by a systematic examination of the established and the principal novel methodologies utilized by leading laboratories conducting research on apoptis. A wide variety of procedures are provided, enabling readers to participate in cutting-edge research.

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification

publisher: Springer, published: 2002-06-15
ASIN: 0896038904
EAN: 9780896038905
sales rank: 4238260
Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.

Apoptosis Detection and Assay Methods (BioTechniques Molecular Laboratory Methods Series, 2)

publisher: Eaton Pub Co, published: 1998-09
ASIN: 1881299074
EAN: 9781881299073
sales rank: 4031459

Apoptosis Techniques and Protocols (Neuromethods)

publisher: Humana Press, published: 2010-11-09
ASIN: 1617373060
EAN: 9781617373060
In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.

Cell Growth and Apoptosis: A Practical Approach (Practical Approach Series)

publisher: Oxford University Press, USA, published: 1995-10-19
ASIN: 0199635684
EAN: 9780199635689
sales rank: 9142450
This text provides a unique combination of succinctly expressed basic concepts of cell growth and cell death with detailed instructions and protocols on how accurately to measure these processes. Practical instructions are accompanied by explanatory material which allows the researcher to choose which particular protocol is most suitable. The methods outlined range from simple techniques such as autoradiography and cell staining, to more complex techniques such as flow cytometry. This book will be essential to laboratory researchers studying the growth, division and death of cells.

Apoptosis

publisher: Springer, published: 1994-06-30
ASIN: 0306447339
EAN: 9780306447334
sales rank: 7473143
Roswell Park Cancer Institute, Buffalo, New York. Proceedings of the Fifth Pezcoller Symposium on Apoptosis, held June 9-11, 1993, in Trento, Italy. Research on programmed cell death (PCD), also called apoptosis, and its possible relationship between cancer and the immune system.

Role of Apoptosis in Development, Tissue Homeostasis and Malignancy: Death from Inside Out

by: R.M. Dexter
publisher: Springer, published: 1995-06-30
ASIN: 041263810X
EAN: 9780412638107
sales rank: 11000018
The role of programmed cell death is recognised as being important in a number of key biological processes, particularly development and maintenance of a healthy organism. This volume, which arises from a Royal Society discussion meeting, provides an up-to-date overview of current research into programmed cell death from top international scientists. Key topics discussed include genetic control of programmed cell death in development, regulation of cell death in cancer cells, influence of signals, modulators and effectors on cell death and clinical applications. Each chapter provides good access to other relevant literature for those not familiar with the area.

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	Apoptosis in Health and Disease: Clinical and Therapeutic Aspects publisher: Cambridge University Press, published: 2012-01-26 ASIN: 052115944X EAN: 9780521159449 sales rank: 4544298 The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.
	Beyond Apoptosis: Cellular Outcomes of Cancer Therapy publisher: INFRMA-HC, published: 2008-09-01 ASIN: 084939192X EAN: 9780849391927 sales rank: 3556711 Apoptosis, the process of deliberate cell death within a multi-cellular organism, has been linked to both the development and the demise of cancer causing cells. Vast research has been conducted on combating cancer cells through apoptosis in radiation and chemotherapy, however, apoptosis plays only a limited role in determining the success of cancer therapy. This realization has been the catalyst necessary to examine alternative mechanisms for the anti-proliferative action of anticancer agents, as well as moving forward in the complete eradication of cancer. The goal of Beyond Apoptosis: Cellular Outcomes of Cancer Therapy is to examine the relative contribution of apoptosis, and to acquaint the readers with new concepts in non-apoptotic cell death, senescence, and mitotic catastrophe.
	Apoptosis, Volume 322 (Methods in Enzymology) publisher: Academic Press, published: 2000-07-19 ASIN: 0121822230 EAN: 9780121822231 sales rank: 3833635 Volume 322 of Methods in Enzymology is dedicated to apoptosis. Major topics covered include measuring apoptosis and apoptosis-induced endonucleases, measuring apoptosis in lower organisms, proteases involved in apoptosis and their inhibitors, cell free systems for monitoring steps in apoptosis pathways, mitochondria and apoptosis, bCl-2 family proteins, and studying receptors and signal transduction events implicated in cell survival and cell death. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
	Apoptosis: A Practical Approach (Practical Approach Series) publisher: Oxford University Press, USA, published: 2000-03-09 ASIN: 0199637857 EAN: 9780199637850 sales rank: 4525535 This important text provides conceptual outlines and detailed procedures for basic and advanced studies of cell death by apoptis. Chapters on the recognition of apoptis as distinguished from neurosis and nonspecific cell DNA damage are followed by a systematic examination of the established and the principal novel methodologies utilized by leading laboratories conducting research on apoptis. A wide variety of procedures are provided, enabling readers to participate in cutting-edge research.
	Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification publisher: Springer, published: 2002-06-15 ASIN: 0896038904 EAN: 9780896038905 sales rank: 4238260 Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
	Apoptosis Detection and Assay Methods (BioTechniques Molecular Laboratory Methods Series, 2) publisher: Eaton Pub Co, published: 1998-09 ASIN: 1881299074 EAN: 9781881299073 sales rank: 4031459
	Apoptosis Techniques and Protocols (Neuromethods) publisher: Humana Press, published: 2010-11-09 ASIN: 1617373060 EAN: 9781617373060 In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.
	Cell Growth and Apoptosis: A Practical Approach (Practical Approach Series) publisher: Oxford University Press, USA, published: 1995-10-19 ASIN: 0199635684 EAN: 9780199635689 sales rank: 9142450 This text provides a unique combination of succinctly expressed basic concepts of cell growth and cell death with detailed instructions and protocols on how accurately to measure these processes. Practical instructions are accompanied by explanatory material which allows the researcher to choose which particular protocol is most suitable. The methods outlined range from simple techniques such as autoradiography and cell staining, to more complex techniques such as flow cytometry. This book will be essential to laboratory researchers studying the growth, division and death of cells.
	Apoptosis publisher: Springer, published: 1994-06-30 ASIN: 0306447339 EAN: 9780306447334 sales rank: 7473143 Roswell Park Cancer Institute, Buffalo, New York. Proceedings of the Fifth Pezcoller Symposium on Apoptosis, held June 9-11, 1993, in Trento, Italy. Research on programmed cell death (PCD), also called apoptosis, and its possible relationship between cancer and the immune system.
	Role of Apoptosis in Development, Tissue Homeostasis and Malignancy: Death from Inside Out by: R.M. Dexter publisher: Springer, published: 1995-06-30 ASIN: 041263810X EAN: 9780412638107 sales rank: 11000018 The role of programmed cell death is recognised as being important in a number of key biological processes, particularly development and maintenance of a healthy organism. This volume, which arises from a Royal Society discussion meeting, provides an up-to-date overview of current research into programmed cell death from top international scientists. Key topics discussed include genetic control of programmed cell death in development, regulation of cell death in cancer cells, influence of signals, modulators and effectors on cell death and clinical applications. Each chapter provides good access to other relevant literature for those not familiar with the area.