Related books on 'epigenetics chromatin'
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publisher: Springer, published: 2011-02-16 ASIN: 1441982159 EAN: 9781441982155 sales rank: 3326832 This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease. |
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publisher: Springer Basel, published: 2010-01-28 ASIN: 3764389885 EAN: 9783764389888 sales rank: 4055553 Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. |
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publisher: The MIT Press, published: 2011-04-22 ASIN: 0262015145 EAN: 9780262015141 sales rank: 1240625 In 1809--the year of Charles Darwin's birth--Jean-Baptiste Lamarck published Philosophie zoologique, the first comprehensive and systematic theory of biological evolution. The Lamarckian approach emphasizes the generation of developmental variations; Darwinism stresses selection. Lamarck's ideas were eventually eclipsed by Darwinian concepts, especially after the emergence of the Modern Synthesis in the twentieth century. The different approaches--which can be seen as complementary rather than mutually exclusive--have important implications for the kinds of questions biologists ask and for the type of research they conduct. Lamarckism has been evolving--or, in Lamarckian terminology, transforming--since Philosophie zoologique's description of biological processes mediated by "subtle fluids." Essays in this book focus on new developments in biology that make Lamarck's ideas relevant not only to modern empirical and theoretical research but also to problems in the philosophy of biology. Contributors discuss the historical transformations of Lamarckism from the 1820s to the 1940s, and the different understandings of Lamarck and Lamarckism; the Modern Synthesis and its emphasis on Mendelian genetics; theoretical and experimental research on such "Lamarckian" topics as plasticity, soft (epigenetic) inheritance, and individuality; and the importance of a developmental approach to evolution in the philosophy of biology. The book shows the advantages of a "Lamarckian" perspective on evolution. Indeed, the development-oriented approach it presents is becoming central to current evolutionary studies--as can be seen in the burgeoning field of Evo-Devo. Transformations of Lamarckism makes a unique contribution to this research. |
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by: C. David Allis publisher: Cold Spring Harbor Laboratory Press, published: 2007-10-31 ASIN: 0879697245 EAN: 9780879697242 sales rank: 403459 The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation. Related Titles from the Publisher Binding and Kinetics for Molecular Biologists; Bioinformatics; The Condensed Protocols From Molecular Cloning: A Laboratory Manual; Discovering Genomics, Proteomics, and Bioinformatics, 2e; DNA Replication and Human Disease; DNA Science; Epigenetics; Genes and Signals; Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual; Genetic Variation; Genomes; Molecular Biology, 6th Edition; Recombinant DNA: Genes and Genomes - A Short Course; The RNA World |
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by: Esra Galun publisher: Springer, published: 2010-12-08 ASIN: 9048163579 EAN: 9789048163571 sales rank: 6338505 There are two major classes of Transposable Elements: Class I elements that are mobilized with an RNA intermediate (retrotransposons), and Class II elements that lack such an intermediate. This book provides a historical background and fully describes all known transposable elements, the modes of their transposition and the utilization of these elements in medicine, genetics, and crop improvement. It is the only text that is targeted at a wide range of readers and can be comprehended also by the novice in this field. |
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by: Nelson R. Cabej publisher: Albanet, published: 2005-02-10 ASIN: 0971074666 EAN: 9780971074668 sales rank: 2271415 The book presents a novel theory on the epigenetic system of heredity supported by extensive experimental and observational evidence. A control system, with the central nervous system as its controller, is responsible for maintaining the inexorably eroding structure of metazoans, including us humans. During individual development, that same system performs functions of an epigenetic system of heredity, providing trillions of bits of information necessary for erecting metazoan structure. The main topics discussed in the book are: |
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by: Moyra Smith M.D. publisher: Oxford University Press, USA, published: 2005-10-27 ASIN: 0195174321 EAN: 9780195174328 sales rank: 1705801 Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential to neurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of both the environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells. |
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publisher: Springer, published: 2011-04-19 ASIN: 1848826435 EAN: 9781848826434 sales rank: 2639303 Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students. |
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publisher: Academic Press, published: 2010-10-28 ASIN: 0123808669 EAN: 9780123808660 sales rank: 3105611 Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. * Explores latest topics in neural circuits and behavior research in zebrafish, drosophila, c.elegans, and mouse models * Includes methods for testing with ethical, legal, and social implications * Critically analyzes prospects future prospects |
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publisher: Humana Press, published: 2004-07-23 ASIN: 158829336X EAN: 9781588293367 sales rank: 2029974 A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer. |