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by: Gary G. Matthews
publisher: Wiley-Blackwell, published: 2001-01-15
ASIN: 0632044969
EAN: 9780632044962
sales rank: 772926
Visit the Neurobiology Website at:
www.blackwellpublishing.com/matthews
As the second edition of a very successful neurobiology book, this text covers a range from molecules to systems, and uses various systems to illustrate each major concept. In addition to the text, this title offers a companion website, which features animations of difficult concepts, online assignments and practice exams, as well as all text figures in an easy to download format.
- Four colour throughout.
- New chapter on hypothalamic function with focus on circadian rhythms.
- More clinical correlation.
- Improved illustration quality and quantity.
- Comprehensive text with excellent coverage of subjects from molecules to systems.
- Use of systems to illustrate each major concept.
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publisher: Academic Press, published: 2009-12-16
ASIN: 0123746345
EAN: 9780123746344
sales rank: 2448053
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise.
The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.
* The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system * Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others * The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community. * Of great value not only for researchers and experts, but also for students and clinicians as a background reference.
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publisher: Humana Press, published: 2010-12-09
ASIN: 1617374105
EAN: 9781617374104
This interdisciplinary review of the cellular and molecular basis of aggression shows how the nerve cell circuitry and the neurochemistry that mediates aggressive behaviors are modified by various environmental and genetic factors. The authors focus on the links to cognition and the neurotransmitter pathways that either promote or suppress violent behavior. They also examine how family environment, early life experiences, exposure to violent video games and movies, religion, and substance abuse effect violent behaviors, including participation in gangs and terrorist organizations. Various behavioral and pharmacological approaches are presented for preventing and treating personal aggression.
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by: Howard Eichenbaum
publisher: Oxford University Press, USA, published: 2002-01-15
ASIN: 019514175X
EAN: 9780195141757
sales rank: 486558
This clear and accessible textbook introduces students to the brain's remarkable capacity for memory. It begins with a history of thinking and research on the biological bases of memory, highlighting discoveries about the brain made in a "Golden Era" of neuroscience around the turn of the 20th century. This is followed by presentation of our current understanding of the neurobiology of memory, organized into sections corresponding to the book's four major themes. The first is Connection, and it considers how memory is based on alterations in the communication between nerve cells. Research on the physiology and biochemistry of neurons has revealed a cascade of molecular events and structural changes that enhance or weaken the connectivity of nerve cells in support of memory. The second theme is Cognition, which considers the psychological structure of memory. Early work on this topic involved controversy over the basic cognitive processes that underlie memory, and modern research has shown that these characterizations reflect distinctions among qualitatively different forms of memory. The third theme is Compartmentalization, the notion that the different forms of memory are accomplished by distinct brain systems. Recent research has revealed parallel memory systems that separately mediate our ability for conscious recollection, our capacity to acquire skills and habits, and our acquisition of emotional attachments and aversions. The fourth theme is Consolidation, the process by which memories are transformed from a labile trace into a permanent store. Scientists have shown that there are two distinct stages in memory consolidation, one involving cellular mechanisms that underlie a fixation of changes in the neuronal connection strengths and the other involving a reorganization and restruction of the circuits that store and retrieve memories. The book assumes little background knowledge from biology or psychology, and is intended as a text for use in undergraduate courses on memory and cognitive science, and for early graduate students in neuroscience, cognitive science, or biology. It encapsulates the major concepts in the field, and makes this area of research accessible to students who pursue a variety of related disciplines.
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publisher: Oxford University Press, USA, published: 1995-06-15
ASIN: 0198547900
EAN: 9780198547907
sales rank: 4065019
Cephalopods (octopus, squid, cuttlefish) are among the most intelligent invertebrates, with highly developed nervous systems which provide excellent model systems for investigating basic questions in neuroscience. Within the last five years, many of the powerful techniques of molecular biology and electrophysiology have been applied to cephalopods, with exciting results. In 32 chapters, this book provides a comprehensive overview of the functioning of the cephalopod nervous system, from the cellular level to their complex sensory systems, locomotion, learning, and social behavior. It will be of interest to both vertebrate and invertebrate neurobiologists, and by anyone interested in the basic principles that control neural function.
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by: Patricia S. Churchland
publisher: Princeton University Press, published: 2011-02-28
ASIN: 069113703X
EAN: 9780691137032
sales rank: 12023
What is morality? Where does it come from? And why do most of us heed its call most of the time? In Braintrust, neurophilosophy pioneer Patricia Churchland argues that morality originates in the biology of the brain. She describes the "neurobiological platform of bonding" that, modified by evolutionary pressures and cultural values, has led to human styles of moral behavior. The result is a provocative genealogy of morals that asks us to reevaluate the priority given to religion, absolute rules, and pure reason in accounting for the basis of morality. Moral values, Churchland argues, are rooted in a behavior common to all mammals--the caring for offspring. The evolved structure, processes, and chemistry of the brain incline humans to strive not only for self-preservation but for the well-being of allied selves--first offspring, then mates, kin, and so on, in wider and wider "caring" circles. Separation and exclusion cause pain, and the company of loved ones causes pleasure; responding to feelings of social pain and pleasure, brains adjust their circuitry to local customs. In this way, caring is apportioned, conscience molded, and moral intuitions instilled. A key part of the story is oxytocin, an ancient body-and-brain molecule that, by decreasing the stress response, allows humans to develop the trust in one another necessary for the development of close-knit ties, social institutions, and morality. A major new account of what really makes us moral, Braintrust challenges us to reconsider the origins of some of our most cherished values.
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by: Howard Eichenbaum
publisher: Oxford University Press, USA, published: 2011-12-21
ASIN: 0199778612
EAN: 9780199778614
sales rank: 895778
This clear and accessible textbook introduces the brain's remarkable capacity for memory. The text was developed for undergraduate and beginning graduate students, but it will also be of use to cognitive scientists, biologists, and psychologists who seek an introduction to biological investigations of memory. Like the first edition, this fully-updated second edition begins with a history of memory research, starting with a "Golden Era" at the turn of the 20th century, and progressing to our current understanding of the neurobiology of memory. Subsequent sections of the book discuss the cellular basis of memory, amnesia in humans and animals, the physiology of memory, declarative, procedural, and emotional memory systems, memory consolidation, and the control of memory by the prefrontal cortex. The book is organized into four sections, which highlight the major themes of the text. The first theme is connection, which considers how memory is fundamentally based on alterations in the connectivity of neurons. This section of the book covers the most well studied models of cellular mechanisms of neural plasticity that may underlie memory. The second theme is cognition, which involves fundamental issues in the psychological structure of memory. This section of the book considers the competition among views on the nature of cognitive processes that underlie memory, and tells how the controversy was eventually resolved. The third theme is compartmentalization, which is akin to the classic problem of memory localization. However, unlike localization, the notion of "compartments" is intended to avoid the notion that particular memories are pigeon-holed into specific loci, and instead emphasize that different forms of memory are accomplished by distinct modules or brain systems. This section of the book surveys the evidence for multiple memory systems, and outlines how they are mediated by different brain structures and systems. The fourth and final theme is consolidation, the process by which memories are transformed from a labile trace into a permanent store. This text encapsulates the major concepts in the field of memory research, and makes this area accessible to students who pursue a variety of related disciplines.
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publisher: Springer, published: 2010-12-06
ASIN: 1441971963
EAN: 9781441971968
sales rank: 3822178
This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.
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publisher: CRC Press, published: 2011-03-28
ASIN: 1420067265
EAN: 9781420067262
sales rank: 2803737
Synthesizing coverage of sensation and reward into a comprehensive systems overview, Neurobiology of Sensation and Reward presents a cutting-edge and multidisciplinary approach to the interplay of sensory and reward processing in the brain. While over the past 70 years these areas have drifted apart, this book makes a case for reuniting sensation and reward by highlighting the important links and interface between the two. Emphasizing the role of reward in reinforcing behaviors, the book begins with an exploration of the history, ecology, and evolution of sensation and reward. Progressing through the five senses, contributors explore how the brain extracts information from sensory cues. The chapter authors examine how different animal species predict rewards, thereby integrating sensation and reward in learning, focusing on effects in anatomy, physiology, and behavior. Drawing on empirical research, contributors build on the themes of the book to present insights into the human sensory rewards of perfume, art, and music, setting the scene for further cross-disciplinary collaborations that bridge the neurobiological interface between sensation and reward.
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publisher: CRC Press, published: 2006-04-25
ASIN: 0849327326
EAN: 9780849327322
sales rank: 1166200
Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment.
The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.
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