Related books on 'recombinant-protein'
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publisher: Cambridge University Press, published: 2009-07-27 ASIN: 0521887321 EAN: 9780521887328 sales rank: 2315354 Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, "arming" mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors. |
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by: Roland Kontermann publisher: Wiley-Blackwell, published: 2012-05-15 ASIN: 3527328491 EAN: 9783527328499 sales rank: 2350341 For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals. |
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publisher: Wiley-VCH, published: 2001-10-15 ASIN: 3527302700 EAN: 9783527302703 sales rank: 6153205 This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology. Foreword written by Jürgen Drews. |
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by: Sarfaraz K. Niazi publisher: Informa Healthcare, published: 2005-08-15 ASIN: 0849329914 EAN: 9780849329913 sales rank: 2766416 Handbook of Biogeneric Therapeutic Proteins is the first book to offer extensive coverage of all aspects of generic or biosimilar biological products, from the scientific basis through the marketing issues. This practical book includes comprehensive information on establishing a manufacturing system and securing regulatory approval for biogeneric pharmaceutical products. It explains how to establish facilities to manufacture the raw materials used in biological products and how to prepare finished products. The author also provides details about the Chemistry, Manufacturing, and Controls (CMC) section of the FDA's New Drug Application for Biological Products. |
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publisher: Academic Press, published: 1994-09-22 ASIN: 0125641443 EAN: 9780125641449 sales rank: 7908525 Critically acclaimed for more than 25 years, the Methods in Cell Biology series provides an indispensable tool for the researcher. Each volume is carefully edited by experts to contain state-of-the-art reviews and step-by-step protocols. Techniques are described completely so that methods are made accessible to users. |
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publisher: Humana Press, published: 2010-11-19 ASIN: 1617376353 EAN: 9781617376351 sales rank: 2887569 Outstanding experts in the use of microorganisms as cell factories describe in step-by-step detail their best laboratory procedures for a wide range of processes and products mediated by microorganisms. The diverse chemicals and biochemicals produced can be used in human health, nutrition, and environmental protection, and include semisynthetic derivatives of cephalosporins, erythromycin, antitumor compounds, plasmids for gene therapy and DNA vaccination , L-lysine, Vitamins B2 and B12, the sweet-tasting protein thaumatin, the carotenoids ß-carotene and astaxanthin, the polysaccharide gellan, and bacteria-producing bacteria for sausage fermentation, and many more. Also illustrated are the uses of phenylacetyl-CoA catabolon for the enzymatic synthesis of penicillins, aromatic biotransformation, syntheses of novel bioplastics, biosensor design, and the synthesis of drug vehicles. This book offers laboratory and industrial scientists a wealth of readily reproducible techniques for the microbial generation of biochemical products serving human health, nutrition, and environmental protection. |
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publisher: CRC Press, published: 1999-05-19 ASIN: 0849333814 EAN: 9780849333811 sales rank: 1511759 Incorporating a bench-top format, G Proteins: Techniques of Analysis covers essential methods - with a commitment to those techniques of proven and current utility. G Proteins: Techniques of Analysis includes expression and functional analysis of G proteins; evaluation of covalent modifications and other regulatory phenomena; and, mapping pathways established among receptors, G proteins, and effectors. Including contributors from key institutions, each author offers clear instructions to establish a synthesized, concise and consistent approach to each chapter, beneficial to students and professionals as well. |
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publisher: Wiley-Liss, published: 1996-02-07 ASIN: 0471103543 EAN: 9780471103547 sales rank: 1497116 PROTEIN ENGINEERING Principles and Practice Edited by JEFFREY L. CLELAND CHARLES S. CRAIK Proteins are involved in every aspect of life-structure, motion, catalysis, recognition and regulation. Protein Engineering: Principles and Practice provides a basic framework for understanding both proteins and protein engineering. This comprehensive book covers general, yet essential knowledge required for successful protein engineering, including everything from the fundamentals to modifying existing proteins and developing new proteins. The book begins by introducing the main concepts of protein engineering, including: understanding protein conformation, comprehending the relationship between protein composition and structure, and potential methods for predicting a protein's conformation. Other major subjects addressed are: * Using different host cell expression systems to produce specific proteins * Protein folding * Structure and function of proteins in relation to drug design * Construction of synthetic metal binding sites in proteins * Manufacture of tissue plasminogen activator * Generation of therapeutic antibodies This broad range of topics provides a solid foundation in protein engineering and supplies readers with knowledge essential to the design and production of proteins. Of primary interest to protein scientists-both students and researchers, in academia as well as industry-Protein Engineering is also extremely useful to chemical engineers, protein chemists, biochemists, and pharmaceutical chemists. |
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publisher: Humana Press, published: 2010-11-19 ASIN: 1617378216 EAN: 9781617378218 sales rank: 2081953 Despite exciting advances in genome sequencing, isolating a protein from its expression system in its native form still presents a complex challenge. In High Throughput Protein Expression and Purification: Methods and Protocols, leading scientists detail the most successful protocols currently in use, including various high throughput cloning schemes, protein expression analysis, and production protocols. This volume describes the use of E. coli, insect, and mammalian cells, as well as cell-free systems for the production of a wide variety of proteins, including glycoproteins and membrane proteins, in order to best represent strategies that create and exploit common features to enable simplified cloning, stable expression, and purification of proteins. Written in the highly successful Methods in Molecular Biology™ series format, the chapters present brief introductions to the subject, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section for tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, High Throughput Protein Expression and Purification: Methods and Protocols is an ideal reference for protein biochemists and all those who wish to apply these easy-to-use protocols to the many applicable fields. |
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publisher: Academic Press, published: 2004-03-05 ASIN: 0120342677 EAN: 9780120342679 sales rank: 5158032 Protein Transcription is a key element of cellular and organ regulation. This volume covers structure and function of all major elements associated with transcription. *Mechanism of RNA polymerase I Transcription *Structure and function of RNA Polymerase II *Structure and function of the TFIID complex *Functional properties of Chromatin Remodeling Enzymes *Posttranslational modification |