Related books on 'transcriptional-regulation'
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publisher: Springer, published: 2010-12-10 ASIN: 1441978224 EAN: 9781441978226 sales rank: 992036 Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book. |
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by: Rudolfs K. Zalups publisher: CRC Press, published: 2010-05-21 ASIN: 1420059971 EAN: 9781420059977 sales rank: 3194392 With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic. This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function. The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level. |
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publisher: Springer, published: 2004-06-17 ASIN: 0306483769 EAN: 9780306483769 sales rank: 935296 Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of niches, including the soil, the plant rhizosphere and phylosphere, and animal tissues; more recently they have attracted attention because of their capacity to form biofilms, a characteristic with potentially important medical and environmental implications. The three volumes cover the following topics: - Taxonomy, - Genomics, - Life styles, - Cell Architecture, - Virulence, - Regulation, - Macromolecules, - Alternative Respiratory Substrates, - Catabolism and Biotransformations. Pseudomonas will be of use to all researchers working on these bacteria, particularly those studying microbiology, plant crops, pathogenesis, and chemical engineering. Advanced students in biology, medicine and agronomy will also find these three volumes a valuable reference during their studies. |
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publisher: Academic Press, published: 1999-11-12 ASIN: 0126366705 EAN: 9780126366709 sales rank: 1020272 This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. Key Features: * Reactive species as intracellular messengers * Redox regulation of cellular responses * Clinical implications of redox signaling and antioxidant therapy |
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publisher: CRC Press, published: 2008-11-18 ASIN: 0849380308 EAN: 9780849380303 sales rank: 1822754 In the 40 years since the classic review of osmotic and ionic regulation written by Potts and Parry, there has been astonishing growth in scientific productivity, a marked shift in the direction and taxonomic distribution of research, and amazing changes in the technology of scientific research "…It is indicative of the growth of the subject that as time passes the number of authors needed to review the subject grows exponentially. The time is ripe for a new survey of the subject and Dr. Evans is to be congratulated on the expert crew that he has recruited." —From the foreword by W.T.W. Potts Osmotic and Ionic Regulation: Cells and Animals not only fills a gap in the literature, but delineates the new approaches, outlooks, and findings that define how the field has changed. Providing the first comprehensive summary of the fundamentally important mechanisms of ionic and osmotic regulation in 40 years, it ties the new findings to the older work of Potts and Parry. This book, written by accepted leaders in this field dealing with the ecology to the molecular biology of the processes and the taxa, provides background information in a broad range of disciplines such as zoology, evolutionary biology, physiology, ichthyology, aquaculture, marine biology, entomology, herpetology, avian biology, human nephrology, conservation biology, and pharmacology. |
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publisher: Springer, published: 2006-03-16 ASIN: 3540239685 EAN: 9783540239680 sales rank: 1681686 The Myc/Mad/Mad network is defined by, and functions through, the interactions between individual Myc and Mad family proteins with Max as well as by interactions between Myc and Mad family proteins with higher order co-repressor and co-activator complexes. The chapters included in this volume illustrate the complexities of the Myc/Max/Mad network and how its functions impinge on fundamental biological processes through regulation of transcription. |
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publisher: Elsevier Science Ltd, published: 1982-10 ASIN: 0444007601 EAN: 9780444007605 |
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publisher: CRC Press, published: 2011-12-05 ASIN: 1439844526 EAN: 9781439844526 sales rank: 1731479 The notion of matching diet with an individual’s genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and gene function. What is emerging is a complex system of interactions that make the human genome exquisitely sensitive to our nutritional environment. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease provides an integrated view of how genomic and epigenetic processes modulate the impact of dietary factors on health. Written as a resource for researchers, nutrition educators, and policy makers, this book contains the latest scientific findings on the mechanisms of action underlying diet-genome interactions. It presents a unique perspective on the fundamentals of nutritional genomics from genomics, transcriptomics, proteomics, and metabolomics. Contributing authors introduce the important areas of cell signaling and transduction, the intricate regulation of gene expression, and alteration of gene-linked chronic diseases, such as obesity-induced inflammation, insulin resistance, metabolic syndrome, cardiovascular disease, and cancer. The authors detail significant areas of interest within nutritional genomics—including plant-based foods as epigenetic modifiers of gene function and the effects of bioactive phytochemicals on inherited genotype and expressed phenotypes. They also discuss the role of vitamin D in various cancer risks and the gastrointestinal tract as a defense system. Given the key role played by agriculture and the food industry to produce foods to meet personalized health needs, the book also addresses agricultural breeding efforts to enhance nutritional value and the use of technology to increase bioactive ingredients in the food supply. The final chapters discuss manufacturing practices and novel processing techniques for retention of nutrients and bioactive components, as well as the need for regulatory oversight and proper labeling to establish assurance of safety and benefit. An excellent resource for this exciting field, the book identifies future directions for research and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet. |
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by: Alexander Bürkle publisher: Springer, published: 2006-05-09 ASIN: 0387333711 EAN: 9780387333717 sales rank: 603747 This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts. |
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by: Jun Ma publisher: Springer, published: 2006-07-27 ASIN: 0387332081 EAN: 9780387332086 sales rank: 2087022 This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches. |