recombinant-protein books

Related books on 'recombinant-protein'

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Purification and Analysis of Recombinant Proteins (Biotechnology and Bioprocessing)

by: R. Seetharam
publisher: CRC Press, published: 1991-01-07
ASIN: 0824782771
EAN: 9780824782771
sales rank: 4796692
Covering both new and traditional topics in the purification and analysis of recombinant proteins, this volume demonstrates how to overcome problems in protein research and presents practical methods used in protein work, explaining their theoretical bases. The collection also explores innovative co

Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena

publisher: Wiley, published: 2009-11-23
ASIN: 0470041382
EAN: 9780470041383
sales rank: 496275
A consolidated and comprehensive reference on ligand-binding assays
Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field.
Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include:
A general discussion of challenges and proven approaches in the development of ligand-binding assays
More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline
A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules
A practical approach to "fit-for-purpose" validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies
Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.

Biosystems Engineering II: Linking Cellular Networks and Bioprocesses (Advances in Biochemical Engineering Biotechnology)

publisher: Springer, published: 2010-09-02
ASIN: 3642138659
EAN: 9783642138652
sales rank: 5266350
-Morphology of Filamentous Fungi: Linking Cellular Biology to Process Engineering Using Aspergillus niger, By Rainer Krull, Christiana Cordes, Harald Horn, Ingo Kampen, Arno Kwade, Thomas R. Neu, and Bernd Nörtemann; -Multi-Scale Spatio-Temporal Modeling: Lifelines of Microorganisms in Bioreactors and Tracking Molecules in Cells, By Alexei Lapin, Michael Klann, and Matthias Reuss; -Impact of Profiling Technologies in the Understanding of Recombinant Protein Production, By Chandran Vijayendran and Erwin Flaschel -Engineering the Escherichia coli Fermentative Metabolism, By M. Orencio-Trejo, J. Utrilla, M.T. Fernàndez-Sandoval, G. Huerta-Beristain, G. Gosset, and A. Martinez; -Modeling Languages for Biochemical Network Simulation: Reaction vs Equation Based Approaches, By Wolfgang Wiechert, Stephan Noack, and Atya Elsheikh; -Impact of Thermodynamic Principles in Systems Biology, By J.J. Heijnen;

Cell Culture and Upstream Processing

publisher: Taylor & Francis, published: 2007-05-25
ASIN: 0415399696
EAN: 9780415399692
sales rank: 243812

Upstream processing refers to the production of proteins by cells genetically engineered to contain the human gene which will express the protein of interest. The demand for large quantities of specific proteins is increasing the pressure to boost cell culture productivity, and optimizing bioreactor output has become a primary concern for most pharmaceutical companies. Each chapter in Cell Culture and Upstream Processing is taken from presentations at the highly acclaimed IBC conferences as well as meetings of the European Society for Animal Cell Technology (ESACT) and Protein Expression in Animal Cells (PEACe) and describes how to improve yield and optimize the cell culture production process for biopharmaceuticals, by focusing on safety, quality, economics and operability and productivity issues.

Cell Culture and Upstream Processing will appeal to a wide scientific audience, both professional practitioners of animal cell technology as well as students of biochemical engineering or biotechnology in graduate or high level undergraduate courses at university.

Process Scale Purification of Antibodies

publisher: Wiley-Interscience, published: 2009-02-09
ASIN: 0470209623
EAN: 9780470209622
sales rank: 174712
Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.

Exploring Proteins: A student's guide to experimental skills and methods

by: Nicholas Price
publisher: Oxford University Press, USA, published: 2009-04-15
ASIN: 0199205701
EAN: 9780199205707
sales rank: 2079693
Exploring Proteins offers a complete course in developing the skills - and self-confidence - to be able to understand the way proteins behave and the basis of the methods used to separate, identify and characterise them.

Finding out about biological molecules and systems is a hands-on, experimental task: Exploring Proteins equips the reader with the skills they need to plan and carry out this experimental work, and to understand, analyse, and present the data their work generates.

With a focus throughout on active learning, the book blends background information on proteins and protein biochemistry, with the methods used to study them, featuring extensive worked examples and questions throughout to help the reader check their understanding, and develop critical data-handling skills for themselves.

It also offers complete flexibility - with sample data sets for readers without access to a lab, and suggested protocols for use where students can be given the opportunity to collect data for themselves.

Mammary Gland Transgenesis: Therapeutic Protein Production (Biotechnology Intelligence Unit)

publisher: Springer, published: 1998-05-15
ASIN: 3540637125
EAN: 9783540637127
sales rank: 9802809
This book presents the latest in mammary gland transgenesis, the exploitation of transgenic technology for the production of therapeutic proteins by routine or conventional methods. Following a section with an overview of all relevant methodologies, readers will find relevant information on the regulation of milk gene expression and bioreactor species such as cattle, rabbits and pigs.

PNH and the GPI-Linked Proteins

publisher: Academic Press, published: 2000-02-25
ASIN: 0123908019
EAN: 9780123908018
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays-based on the chemistry of the proteins-can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.

Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives

by: Roland Kontermann
publisher: Wiley-Blackwell, published: 2012-04-03
ASIN: 3527328491
EAN: 9783527328499
sales rank: 1346288
For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.

Vaccines against Allergies (Current Topics in Microbiology and Immunology)

publisher: Springer, published: 2011-08-31
ASIN: 3642200532
EAN: 9783642200533
sales rank: 6024445
We are celebrating this year the hundred years´ anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin” by administering increasing doses of grass pollen extract before the grass pollen season to allergic patients. Although it was unknown at that time that allergy represents an immunological hypersensitivity disease, the treatment was effective and many observations made by Noon remained valid until today. Today allergen-specific immunotherapy is well established as the only allergen-specific and disease-modifying treatment for IgE-mediated allergies and has long-lasting effects. In fact, more than 25% of the population suffer from IgE-mediated allergies which therefore represent a major health burden of our society, particularly because untreated allergy often progresses to severe disabling forms of disease, such as asthma and sometimes kills sensitized people through anaphylaxis.

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	Purification and Analysis of Recombinant Proteins (Biotechnology and Bioprocessing) by: R. Seetharam publisher: CRC Press, published: 1991-01-07 ASIN: 0824782771 EAN: 9780824782771 sales rank: 4796692 Covering both new and traditional topics in the purification and analysis of recombinant proteins, this volume demonstrates how to overcome problems in protein research and presents practical methods used in protein work, explaining their theoretical bases. The collection also explores innovative co
	Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena publisher: Wiley, published: 2009-11-23 ASIN: 0470041382 EAN: 9780470041383 sales rank: 496275 A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to "fit-for-purpose" validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
	Biosystems Engineering II: Linking Cellular Networks and Bioprocesses (Advances in Biochemical Engineering Biotechnology) publisher: Springer, published: 2010-09-02 ASIN: 3642138659 EAN: 9783642138652 sales rank: 5266350 -Morphology of Filamentous Fungi: Linking Cellular Biology to Process Engineering Using Aspergillus niger, By Rainer Krull, Christiana Cordes, Harald Horn, Ingo Kampen, Arno Kwade, Thomas R. Neu, and Bernd Nörtemann; -Multi-Scale Spatio-Temporal Modeling: Lifelines of Microorganisms in Bioreactors and Tracking Molecules in Cells, By Alexei Lapin, Michael Klann, and Matthias Reuss; -Impact of Profiling Technologies in the Understanding of Recombinant Protein Production, By Chandran Vijayendran and Erwin Flaschel -Engineering the Escherichia coli Fermentative Metabolism, By M. Orencio-Trejo, J. Utrilla, M.T. Fernàndez-Sandoval, G. Huerta-Beristain, G. Gosset, and A. Martinez; -Modeling Languages for Biochemical Network Simulation: Reaction vs Equation Based Approaches, By Wolfgang Wiechert, Stephan Noack, and Atya Elsheikh; -Impact of Thermodynamic Principles in Systems Biology, By J.J. Heijnen;
	Cell Culture and Upstream Processing publisher: Taylor & Francis, published: 2007-05-25 ASIN: 0415399696 EAN: 9780415399692 sales rank: 243812 Upstream processing refers to the production of proteins by cells genetically engineered to contain the human gene which will express the protein of interest. The demand for large quantities of specific proteins is increasing the pressure to boost cell culture productivity, and optimizing bioreactor output has become a primary concern for most pharmaceutical companies. Each chapter in Cell Culture and Upstream Processing is taken from presentations at the highly acclaimed IBC conferences as well as meetings of the European Society for Animal Cell Technology (ESACT) and Protein Expression in Animal Cells (PEACe) and describes how to improve yield and optimize the cell culture production process for biopharmaceuticals, by focusing on safety, quality, economics and operability and productivity issues. Cell Culture and Upstream Processing will appeal to a wide scientific audience, both professional practitioners of animal cell technology as well as students of biochemical engineering or biotechnology in graduate or high level undergraduate courses at university.
	Process Scale Purification of Antibodies publisher: Wiley-Interscience, published: 2009-02-09 ASIN: 0470209623 EAN: 9780470209622 sales rank: 174712 Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.
	Exploring Proteins: A student's guide to experimental skills and methods by: Nicholas Price publisher: Oxford University Press, USA, published: 2009-04-15 ASIN: 0199205701 EAN: 9780199205707 sales rank: 2079693 Exploring Proteins offers a complete course in developing the skills - and self-confidence - to be able to understand the way proteins behave and the basis of the methods used to separate, identify and characterise them. Finding out about biological molecules and systems is a hands-on, experimental task: Exploring Proteins equips the reader with the skills they need to plan and carry out this experimental work, and to understand, analyse, and present the data their work generates. With a focus throughout on active learning, the book blends background information on proteins and protein biochemistry, with the methods used to study them, featuring extensive worked examples and questions throughout to help the reader check their understanding, and develop critical data-handling skills for themselves. It also offers complete flexibility - with sample data sets for readers without access to a lab, and suggested protocols for use where students can be given the opportunity to collect data for themselves.
	Mammary Gland Transgenesis: Therapeutic Protein Production (Biotechnology Intelligence Unit) publisher: Springer, published: 1998-05-15 ASIN: 3540637125 EAN: 9783540637127 sales rank: 9802809 This book presents the latest in mammary gland transgenesis, the exploitation of transgenic technology for the production of therapeutic proteins by routine or conventional methods. Following a section with an overview of all relevant methodologies, readers will find relevant information on the regulation of milk gene expression and bioreactor species such as cattle, rabbits and pigs.
	PNH and the GPI-Linked Proteins publisher: Academic Press, published: 2000-02-25 ASIN: 0123908019 EAN: 9780123908018 Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays-based on the chemistry of the proteins-can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.
	Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives by: Roland Kontermann publisher: Wiley-Blackwell, published: 2012-04-03 ASIN: 3527328491 EAN: 9783527328499 sales rank: 1346288 For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
	Vaccines against Allergies (Current Topics in Microbiology and Immunology) publisher: Springer, published: 2011-08-31 ASIN: 3642200532 EAN: 9783642200533 sales rank: 6024445 We are celebrating this year the hundred years´ anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work “Prophylactic inoculation against hay fever” describing his attempts to achieve active immunity against “grass pollen toxin” by administering increasing doses of grass pollen extract before the grass pollen season to allergic patients. Although it was unknown at that time that allergy represents an immunological hypersensitivity disease, the treatment was effective and many observations made by Noon remained valid until today. Today allergen-specific immunotherapy is well established as the only allergen-specific and disease-modifying treatment for IgE-mediated allergies and has long-lasting effects. In fact, more than 25% of the population suffer from IgE-mediated allergies which therefore represent a major health burden of our society, particularly because untreated allergy often progresses to severe disabling forms of disease, such as asthma and sometimes kills sensitized people through anaphylaxis.