Related books on 'signal-transduction'
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publisher: Humana Press, published: 2010-11-05 ASIN: 1617375128 EAN: 9781617375125 sales rank: 4560745 Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. |
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publisher: Wiley-Blackwell, published: 2007-05-22 ASIN: 1573316458 EAN: 9781573316453 sales rank: 3090658 Keynote speakers at the cell signaling meeting in Luxembourg have provided chapters on hypoxia signal transduction, phosphoserine/threonine-binding domains, targeting of polycomb repressive complexes, conserved signaling mechanisms in innate immunity, and signal transduction by stress-activated MAP kinases. Other topics included among these reports on recent research are receptor signaling, protein kinase cascades as therapeutic targets, cell death in cancer, inflammation-specific signaling, cell signaling pathways leading to regulated chromatin modifications, and transcriptional control. The chapters have been published in four volumes (Part A to D), offering a comprehensive overview about this exciting topic. This first volume focuses on basic research, and the chapters are divided into the following sections: apoptotic cell signaling mechanisms, extracellular matrix interactions, and MAP kinases. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member |
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publisher: Springer, published: 2010-11-10 ASIN: 1617374482 EAN: 9781617374487 sales rank: 6891123 Carrying on the high standards of the much-acclaimed first edition, highly experienced investigators have extensively updated the first edition with many of the new approaches that have been transforming the field. Included in this new edition are readily reproducible immunoassays, fluorescence-based assays, high-throughput methods, protein modification assays, lipid second messenger assays, and chromatin immunoprecipitation techniques. Wherever possible, protocols for the assay of general classes of signal transduction components have been identified so they can be adapted to the assay of any member of that class. |
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publisher: Wiley-IEEE Press, published: 2001-01-01 ASIN: 0780360109 EAN: 9780780360105 sales rank: 400565 "IEEE Press is proud to present the first selected reprint volume devoted to the new field of intelligent signal processing (ISP). ISP differs fundamentally from the classical approach to statistical signal processing in that the input-output behavior of a complex system is modeled by using "intelligent" or "model-free" techniques, rather than relying on the shortcomings of a mathematical model. Information is extracted from incoming signal and noise data, making few assumptions about the statistical structure of signals and their environment. Intelligent Signal Processing explores how ISP tools address the problems of practical neural systems, new signal data, and blind fuzzy approximators. The editors have compiled 20 articles written by prominent researchers covering 15 diverse, practical applications of this nascent topic, exposing the reader to the signal processing power of learning and adaptive systems. This essential reference is intended for researchers, professional engineers, and scientists working in statistical signal processing and its applications in various fields such as humanistic intelligence, stochastic resonance, financial markets, optimization, pattern recognition, signal detection, speech processing, and sensor fusion. Intelligent Signal Processing is also invaluable for graduate students and academics with a background in computer science, computer engineering, or electrical engineering. About the Editors Simon Haykin is the founding director of the Communications Research Laboratory at McMaster University, Hamilton, Ontario, Canada, where he serves as university professor. His research interests include nonlinear dynamics, neural networks and adaptive filters and their applications in radar and communications systems. Dr. Haykin is the editor for a series of books on "Adaptive and Learning Systems for Signal Processing, Communications and Control" (Publisher) and is both an IEEE Fellow and Fellow of the Royal Society of Canada. Bart Kosko is a past director of the University of Southern California's (USC) Signal and Image Processing Institute. He has authored several books, including Neural Networks and Fuzzy Systems, Neural Networks for Signal Processing (Publisher, copyright date) and Fuzzy Thinking (Publisher, copyright date), as well as the novel Nanotime (Publisher, copyright date). Dr. Kosko is an elected governor of the International Neural Network Society and has chaired many neural and fuzzy system conferences. Currently, he is associate professor of electrical engineering at USC." |
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publisher: Springer, published: 2010-11-19 ASIN: 3642068340 EAN: 9783642068348 sales rank: 5587973 This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs? |
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publisher: Humana Press, published: 2011-08-30 ASIN: 1617791598 EAN: 9781617791598 sales rank: 1535954 It is increasingly clear that signal transduction is a highly organized and integrated process. Divided into two convenient sections, Signal Transduction Protocols, Third Edition focuses on experimental approaches to better understand the complexity of signal transduction. Introductory chapters provide perspective on several of the challenges involved in signal transduction research and offer guidance on selecting the best approaches to various types of questions. The individual chapters provide detailed experimental protocols covering various topics, from the effects of ligand binding on receptor conformation and effector coupling, to moving inside the cell in order to capture the spatial and temporal characteristics of signaling events. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Signal Transduction Protocols serves as an ideal guide to scientists of all backgrounds and is a valuable resource for future progress in the field of signal transduction research. |
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publisher: Elsevier Science, published: 2005-07-20 ASIN: 0444515003 EAN: 9780444515001 sales rank: 3855598 Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin. |
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publisher: CRC Press, published: 2005-11-21 ASIN: 0849327830 EAN: 9780849327834 sales rank: 3542107 The first edition of James Putney’s Calcium Signaling offered readers a comprehensive view of the fascinating diversity of technologies that the new field of calcium signaling employed. And while that work is still regarded as a premier text on the basics of calcium signaling, progress has been so dramatic that an update is now required. In Calcium Signaling, Second Edition, Putney focuses on those processes that generate calcium signals to compile the first comprehensive exploration of calcium signaling research from a methodological standpoint. This new edition deals with methods for studying calcium from a variety of perspectives. Several chapters discuss calcium indicators and other tools, and look at microscopic and electrophysiological techniques, as well as other special methodological aspects of calcium signaling research. Other chapters examine the study of different systems, ranging from those found in yeast to those found in mammals, and several more are devoted to the cellular and molecular basis for calcium signaling, including explorations of receptors, calcium pumps, apoptosis, and drug delivery. Once again, Putney has called upon top researchers from across the globe to contribute their expertise. Several new chapters have been added and in many cases, where chapters from the first edition were retained, new researchers were recruited to offer a fresh perspective.
As calcium signaling involves such a breadth of technical approaches and a wide range of applications, this work contains invaluable information for established researchers, as well as those graduate students and scientists just beginning to find a direction in cellular calcium signaling. |
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by: David A. Kendall publisher: Humana Press, published: 1995-04-04 ASIN: 0896032981 EAN: 9780896032989 sales rank: 3591757 This collection of self-contained, "hands-on" descriptions of established laboratory protocols concentrates on receptor-mediated cell signaling, with particular attention devoted to those receptors that are part of the G-protein-linked superfamily. It offers those already working in the field as well as those in related areas the opportunity to expand their range of experimental techniques and to carry out successful investigations without needing to refer to any other methodological source. |
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publisher: Springer, published: 2011-07-29 ASIN: 9048162165 EAN: 9789048162161 sales rank: 4192742 This exciting area of research will benefit from the pulling together of the work from hard-core chemists and free radical aficionados along with that of signaling enthusiasts and cell biologist devotees. This was the idea behind the conception of this new book. Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles provides relevant chemistry that can be applied across signaling systems and summarizes the current state of knowledge in the area of redox signaling, including controversies when they exist and future directions. ROS and RNS have been implicated in inflammation, aging and cancer and their novel role in signal transduction may offer new clues to their participation in these processes. This volume should be of great interest to researchers involved in a large range of scientific fields from biochemistry and physiology to pharmacology. |