apoptosis books

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Apoptosis in Inflammation (Progress in Inflammation Research)

publisher: Birkhäuser Basel, published: 1999-07-30
ASIN: 3764357959
EAN: 9783764357955
sales rank: 7842455
Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.

Apoptosis and Cancer

by: Seamus J. (ed.) Martin
publisher: S Karger Pub, published: 1997-08
ASIN: 3805565798
EAN: 9783805565790
sales rank: 8633449
This is an up-to-date overview of knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. The book synthesizes developments in this area and places them in perspective. It gives a basic introduction to the cell death machinery and its role in tumour development and progression and also explores aspects of apoptosis research, including the involvement of cell cycle-related proteins ( for example cyclin-dependent kinases) in apoptosis, the role of Bcl-Abl, Rb, p53 and myc in the regulation of cell death and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukaemia and neuroblastoma. The book also discusses how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells.

Apoptosis And Its Relevance to Autoimmunity (Current Directions in Autoimmunity)

publisher: S Karger Pub, published: 2005-12-31
ASIN: 3805580363
EAN: 9783805580366
sales rank: 6505754
Over the last 15 years, apoptosis has become a dominant focus of medical research in the field of immunology. This publication discusses the three major areas of apoptosis research: extrinsic death receptor pathways, intrinsic cell death pathways and the mechanisms responsible for apoptotic cell clearance. Each section delineates the proteins and signal transduction pathways and describes genetic alterations that lead to autoimmune diseases. Although most cell death abnormalities have been associated with systemic autoimmune disorders such as lupus erythematosus and lymphoproliferative syndromes, it is evident that regulation of cell death is also pertinent to disease expression in many organ-specific diseases such as rheumatoid arthritis and glomerulonephritis.This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of disease. It is of special interest to cell biologists, immunologists and clinicians.

Growth, Proliferation, and Apoptosis of Hepatocytes

publisher: Springer, published: 2001-12-07
ASIN: 4431703233
EAN: 9784431703235
sales rank: 5840534
To gain a better understanding of the pathology of liver disease, the signaling system controlling hepatocyte differentiation, proliferation, and apoptosis was selected as the theme of the 12th Yamaguchi Symposium on Liver Diseases. Ten leading researchers presented their latest experimental results. Focusing on apoptosis, guest speaker Professor D.A. Brenner, USA, spoke on the regulation of tumor necrosis factor alpha and Fas ligand-induced hepatic apoptosis by nerve factor-kappa B. Other researchers covered the molecular basis for clonal deletion therapy in hepatocellular carcinoma, hepatitis C virus induction of proliferation signals, helix-loop-helix protein in liver-specific gene expression, and reconstitution of hepatic tissues using liver stem cells, among other topics of current interest. These proceedings thus serve as a useful resource for all involved in hepatology research.

Chemo-Immunosensitization of Resistant Tumor Cells to Cell Death by Apoptosis 2006

by: Edited by Benjamin Bonavida
publisher: Transworld Research Network, published: 2006-01-01
ASIN: 8178952424
EAN: 9788178952420
This volume has been conceived to provide different approaches used to overcome resistance through the use of chemo or immunosensitizing agents, used in combination with cytotoxic drugs. This volume has been divided arbitrarily into two sections, namely, chemosensitization and immunosensitization. Chemosensitization refers to the use of sensitizing agents that can reverse resistance to chemotherapeutic drugs. Immunosensitization refers to agents that can sensitize tumor cells through cytotoxic mechanisms mediated by host immune cells and/or corresponding cytotoxic factors. The authors in this volume are well established investigators in the field of sensitization and represent expertise in novel approaches used for sensitization. This volume is by no means all inclusive and primarily represents some examples that have been selected for reference.

Cell Engineering: Apoptosis

publisher: Springer, published: 2010-11-10
ASIN: 9048166152
EAN: 9789048166152
The series Cell Engineering is the first and only major reference work on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. This volume on "Apoptosis" is intended to review the state-of-the-art with in-depth assessments of this type of programmed cell death. The aim of the volume is to make the recent developments in apoptotic research readily accessible to biologists, biotechnologists and cellular engineers. The implication of apoptosis in the suppression of diseases and prolonging survival of cells in culture is presented to indicate the great potential of apoptotic research for drug production and the development of human therapies. All chapters are written as self-contained treatments of the important topics in apoptosis that are presented on an essential information basis. Topics covered range from understanding the role of signalling and effector molecules, mathematical modelling of cell death, RNAi tools in apoptosis research, to monitoring and imaging of apoptosis. This volume will be an invaluable resource for biotechnologists and researchers in apoptosis, cell biology, cell culture and molecular medicine.

Apoptosis-related: Webster's Timeline History, 1992 - 2007

by: Icon Group International
publisher: ICON Group International, Inc., published: 2010-05-17
ASIN: B003NE5FLO
Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Apoptosis-related," including when used in literature (e.g. all authors that might have Apoptosis-related in their name). As such, this book represents the largest compilation of timeline events associated with Apoptosis-related when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Apoptosis-related, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification

publisher: Springer, published: 2002-06-15
ASIN: 0896038904
EAN: 9780896038905
sales rank: 4201715
Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.

Apoptosis in Health and Disease (New Horizons in Therpeutics : Smithkline Beecham Pharmaceuticals U.S. Research Symposia Series)

publisher: CRC Press, published: 2000-09-15
ASIN: 9058230864
EAN: 9789058230867
sales rank: 9957384
The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society.
Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.

Apoptosis: Methods and Protocols, Second Edition (Methods in Molecular Biology)

publisher: Humana Press, published: 2009-07-15
ASIN: 1603270167
EAN: 9781603270168
sales rank: 2263199
The ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modifications of apoptotic proteins during apoptosis, the analysis of its major regulators, as well as analysis of apoptosis in different organs and in model organisms. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Apoptosis: Methods and Protocols, Second Edition constitutes a key technical reference to the significant methodologies used in the field, and offers beginners and experienced researchers powerful tools to illuminate the phenomena of programmed cell death.

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	Apoptosis in Inflammation (Progress in Inflammation Research) publisher: Birkhäuser Basel, published: 1999-07-30 ASIN: 3764357959 EAN: 9783764357955 sales rank: 7842455 Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.
	Apoptosis and Cancer by: Seamus J. (ed.) Martin publisher: S Karger Pub, published: 1997-08 ASIN: 3805565798 EAN: 9783805565790 sales rank: 8633449 This is an up-to-date overview of knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. The book synthesizes developments in this area and places them in perspective. It gives a basic introduction to the cell death machinery and its role in tumour development and progression and also explores aspects of apoptosis research, including the involvement of cell cycle-related proteins ( for example cyclin-dependent kinases) in apoptosis, the role of Bcl-Abl, Rb, p53 and myc in the regulation of cell death and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukaemia and neuroblastoma. The book also discusses how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells.
	Apoptosis And Its Relevance to Autoimmunity (Current Directions in Autoimmunity) publisher: S Karger Pub, published: 2005-12-31 ASIN: 3805580363 EAN: 9783805580366 sales rank: 6505754 Over the last 15 years, apoptosis has become a dominant focus of medical research in the field of immunology. This publication discusses the three major areas of apoptosis research: extrinsic death receptor pathways, intrinsic cell death pathways and the mechanisms responsible for apoptotic cell clearance. Each section delineates the proteins and signal transduction pathways and describes genetic alterations that lead to autoimmune diseases. Although most cell death abnormalities have been associated with systemic autoimmune disorders such as lupus erythematosus and lymphoproliferative syndromes, it is evident that regulation of cell death is also pertinent to disease expression in many organ-specific diseases such as rheumatoid arthritis and glomerulonephritis.This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of disease. It is of special interest to cell biologists, immunologists and clinicians.
	Growth, Proliferation, and Apoptosis of Hepatocytes publisher: Springer, published: 2001-12-07 ASIN: 4431703233 EAN: 9784431703235 sales rank: 5840534 To gain a better understanding of the pathology of liver disease, the signaling system controlling hepatocyte differentiation, proliferation, and apoptosis was selected as the theme of the 12th Yamaguchi Symposium on Liver Diseases. Ten leading researchers presented their latest experimental results. Focusing on apoptosis, guest speaker Professor D.A. Brenner, USA, spoke on the regulation of tumor necrosis factor alpha and Fas ligand-induced hepatic apoptosis by nerve factor-kappa B. Other researchers covered the molecular basis for clonal deletion therapy in hepatocellular carcinoma, hepatitis C virus induction of proliferation signals, helix-loop-helix protein in liver-specific gene expression, and reconstitution of hepatic tissues using liver stem cells, among other topics of current interest. These proceedings thus serve as a useful resource for all involved in hepatology research.
	Chemo-Immunosensitization of Resistant Tumor Cells to Cell Death by Apoptosis 2006 by: Edited by Benjamin Bonavida publisher: Transworld Research Network, published: 2006-01-01 ASIN: 8178952424 EAN: 9788178952420 This volume has been conceived to provide different approaches used to overcome resistance through the use of chemo or immunosensitizing agents, used in combination with cytotoxic drugs. This volume has been divided arbitrarily into two sections, namely, chemosensitization and immunosensitization. Chemosensitization refers to the use of sensitizing agents that can reverse resistance to chemotherapeutic drugs. Immunosensitization refers to agents that can sensitize tumor cells through cytotoxic mechanisms mediated by host immune cells and/or corresponding cytotoxic factors. The authors in this volume are well established investigators in the field of sensitization and represent expertise in novel approaches used for sensitization. This volume is by no means all inclusive and primarily represents some examples that have been selected for reference.
	Cell Engineering: Apoptosis publisher: Springer, published: 2010-11-10 ASIN: 9048166152 EAN: 9789048166152 The series Cell Engineering is the first and only major reference work on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. This volume on "Apoptosis" is intended to review the state-of-the-art with in-depth assessments of this type of programmed cell death. The aim of the volume is to make the recent developments in apoptotic research readily accessible to biologists, biotechnologists and cellular engineers. The implication of apoptosis in the suppression of diseases and prolonging survival of cells in culture is presented to indicate the great potential of apoptotic research for drug production and the development of human therapies. All chapters are written as self-contained treatments of the important topics in apoptosis that are presented on an essential information basis. Topics covered range from understanding the role of signalling and effector molecules, mathematical modelling of cell death, RNAi tools in apoptosis research, to monitoring and imaging of apoptosis. This volume will be an invaluable resource for biotechnologists and researchers in apoptosis, cell biology, cell culture and molecular medicine.
	Apoptosis-related: Webster's Timeline History, 1992 - 2007 by: Icon Group International publisher: ICON Group International, Inc., published: 2010-05-17 ASIN: B003NE5FLO Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Apoptosis-related," including when used in literature (e.g. all authors that might have Apoptosis-related in their name). As such, this book represents the largest compilation of timeline events associated with Apoptosis-related when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This "data dump" results in a comprehensive set of entries for a bibliographic and/or event-based timeline on the proper name Apoptosis-related, since editorial decisions to include or exclude events is purely a linguistic process. The resulting entries are used under license or with permission, used under "fair use" conditions, used in agreement with the original authors, or are in the public domain.
	Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification publisher: Springer, published: 2002-06-15 ASIN: 0896038904 EAN: 9780896038905 sales rank: 4201715 Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
	Apoptosis in Health and Disease (New Horizons in Therpeutics : Smithkline Beecham Pharmaceuticals U.S. Research Symposia Series) publisher: CRC Press, published: 2000-09-15 ASIN: 9058230864 EAN: 9789058230867 sales rank: 9957384 The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society. Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.
	Apoptosis: Methods and Protocols, Second Edition (Methods in Molecular Biology) publisher: Humana Press, published: 2009-07-15 ASIN: 1603270167 EAN: 9781603270168 sales rank: 2263199 The ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modifications of apoptotic proteins during apoptosis, the analysis of its major regulators, as well as analysis of apoptosis in different organs and in model organisms. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Apoptosis: Methods and Protocols, Second Edition constitutes a key technical reference to the significant methodologies used in the field, and offers beginners and experienced researchers powerful tools to illuminate the phenomena of programmed cell death.