epigenetics chromatin books

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Keywords and Concepts in Evolutionary Developmental Biology (Harvard University Press Reference Library)

publisher: Harvard University Press, published: 2006-09-01
ASIN: 0674022408
EAN: 9780674022409
sales rank: 1296381

The new field of evolutionary developmental biology is one of the most exciting areas of contemporary biology. The fundamental principle of evolutionary developmental biology ("evo-devo") is that evolution acts through inherited changes in the development of the organism. "Evo-devo" is not merely a fusion of the fields of developmental and evolutionary biology, the grafting of a developmental perspective onto evolutionary biology, or the incorporation of an evolutionary perspective into developmental biology. Evo-devo strives for a unification of genomic, developmental, organismal, population, and natural selection approaches to evolutionary change. It draws from development, evolution, paleontology, ecology, and molecular and systematic biology, but has its own set of questions, approaches, and methods.
Keywords and Concepts in Evolutionary Developmental Biology is the first comprehensive reference work for this expanding field. Covering more than fifty central terms and concepts in entries written by leading experts, Keywords offers an overview of all that is embraced by this new subdiscipline of biology, providing the core insights and ideas that show how embryonic development relates to life-history evolution, adaptation, and responses to and integration with environmental factors.
(20031101)

Centromere: Structure and Evolution (Progress in Molecular and Subcellular Biology)

publisher: Springer, published: 2009-05-27
ASIN: 3642001815
EAN: 9783642001819
sales rank: 3139854
The centromere is a chromosomal locus that regulates the proper pairing and segregation of the chromosomes during cell division. Despite their conserved, essential function, centromeres are characterized by the rapid evolution of both centromeric DNA and proteins. This book presents current views on centromere structure and identity. It deals with the epigenetic concept of centromere establishment and maintenance as well as with the role of DNA and centromeric transcripts in centromere formation and function. Special emphasis is placed on centromere evolution: different evolutionary models are discussed in detail and the latest research on the evolution of new centromeres and neocentromeres is presented.

Body by Science: A Research Based Program to Get the Results You Want in 12 Minutes a Week

by: John Little
publisher: McGraw-Hill, published: 2008-12-11
ASIN: 0071597174
EAN: 9780071597173
sales rank: 2072

Building muscle has never been faster or easier than with this revolutionary once-a-week training program

In Body By Science, bodybuilding powerhouse John Little teams up with fitness medicine expert Dr. Doug McGuff to present a scientifically proven formula for maximizing muscle development in just 12 minutes a week. Backed by rigorous research, the authors prescribe a weekly high-intensity program for increasing strength, revving metabolism, and building muscle for a total fitness experience.

The Scientific American Brave New Brain: How Neuroscience, Brain-Machine Interfaces, Neuroimaging, Psychopharmacology, Epigenetics, the Internet, and ... and Enhancing the Future of Mental Power

by: Judith Horstman
publisher: Jossey-Bass, published: 2010-04-05
ASIN: 0470376244
EAN: 9780470376249
sales rank: 182725
This fascinating and highly accessible book presents fantastic but totally feasible projections of what your brain may be capable of in the near future. It shows how scientific breakthroughs and amazing research are turning science fiction into science fact. In this brave new book, you'll explore:
How partnerships between biological sciences and technology are helping the deaf hear, the blind see, and the paralyzed communicate.
How our brains can repair and improve themselves, erase traumatic memories
How we can stay mentally alert longer—and how we may be able to halt or even reverse Alzheimers
How we can control technology with brain waves, including prosthetic devices, machinery, computers—and even spaceships or clones.
Insights into how science may cure fatal diseases, and improve our intellectual and physical productivity
Judith Horstman presents a highly informative and entertaining look at the future of your brain, based on articles from Scientific American and Scientific American Mind magazines, and the work of today’s visionary neuroscientists.

Environmental Epigenomics in Health and Disease (Epigenetics and Human Health)

publisher: Springer, published: 2012-07-28
ASIN: 3642233791
EAN: 9783642233791
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Chromatin and Disease (Subcellular Biochemistry)

publisher: Springer, published: 2007-04-04
ASIN: 1402054653
EAN: 9781402054655
sales rank: 2470076
This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.

DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment)

publisher: Springer, published: 2011-01-11
ASIN: 9048169178
EAN: 9789048169177
sales rank: 3317414
This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.

Neural Control of Development: The Epigenetic Theory of Heredity

by: Nelson R. Cabej
publisher: Albanet, published: 2005-12-06
ASIN: 0971074607
EAN: 9780971074606
sales rank: 2451401
The book presents a novel theory on the epigenetic system of heredity supported by extensive experimental and observational evidence. A control system, with the central nervous system as its controller, is responsible for maintaining the inexorably eroding structure of metazoans, including us humans. During individual development, that same system performs functions of an epigenetic system of heredity, providing trillions of bits of information necessary for erecting metazoan structure. The main topics discussed in the book are: - Hereditary systems as control systems - The integrated control system and the control of gene expression - Manipulative expression of genes in the central nervous system - The epigenetic control of reproduction - The epigenetic system of heredity - The epigenetics of evolutionary change

The Mysterious Epigenome: What Lies Beyond DNA

by: Thomas Woodward
publisher: Kregel Publications, published: 2011-12-01
ASIN: 0825441927
EAN: 9780825441929
sales rank: 32048
In this creative and inventive treatment, authors Thomas E. Woodward and James P. Gills take readers on an exploration of the human epigenome. Acting as tour guides leading visitors through a 3-D model of a human cell, Woodward and Gills bring to life the human molecular makeup. Readers (as visitors) will get up close and personal with the minute details of human molecular structure, including E. coli, flagellum, a DNA helix, an RNA molecule, and more. By seeing it with their own eyes, readers will gain a better understanding of their genetic systems and a better appreciation for the Creator who put this all into place.

Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life (Life and Mind: Philosophical Issues in Biology and Psychology)

by: Eva Jablonka
publisher: The MIT Press, published: 2005-05-01
ASIN: 0262101076
EAN: 9780262101073
sales rank: 1292648
Ideas about heredity and evolution are undergoing a revolutionary change. New findings in molecular biology challenge the gene-centered version of Darwinian theory according to which adaptation occurs only through natural selection of chance DNA variations. In Evolution in Four Dimensions, Eva Jablonka and Marion Lamb argue that there is more to heredity than genes. They trace four "dimensions" in evolution—four inheritance systems that play a role in evolution: genetic, epigenetic (or non-DNA cellular transmission of traits), behavioral, and symbolic (transmission through language and other forms of symbolic communication). These systems, they argue, can all provide variations on which natural selection can act. Evolution in Four Dimensions offers a richer, more complex view of evolution than the gene-based, one-dimensional view held by many today. The new synthesis advanced by Jablonka and Lamb makes clear that induced and acquired changes also play a role in evolution.

After discussing each of the four inheritance systems in detail, Jablonka and Lamb "put Humpty Dumpty together again" by showing how all of these systems interact. They consider how each may have originated and guided evolutionary history and they discuss the social and philosophical implications of the four-dimensional view of evolution. Each chapter ends with a dialogue in which the authors engage the contrarieties of the fictional (and skeptical) "I.M.," or Ifcha Mistabra—Aramaic for "the opposite conjecture"—refining their arguments against I.M.'s vigorous counterarguments. The lucid and accessible text is accompanied by artist-physician Anna Zeligowski's lively drawings, which humorously and effectively illustrate the authors' points.

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	Keywords and Concepts in Evolutionary Developmental Biology (Harvard University Press Reference Library) publisher: Harvard University Press, published: 2006-09-01 ASIN: 0674022408 EAN: 9780674022409 sales rank: 1296381 The new field of evolutionary developmental biology is one of the most exciting areas of contemporary biology. The fundamental principle of evolutionary developmental biology ("evo-devo") is that evolution acts through inherited changes in the development of the organism. "Evo-devo" is not merely a fusion of the fields of developmental and evolutionary biology, the grafting of a developmental perspective onto evolutionary biology, or the incorporation of an evolutionary perspective into developmental biology. Evo-devo strives for a unification of genomic, developmental, organismal, population, and natural selection approaches to evolutionary change. It draws from development, evolution, paleontology, ecology, and molecular and systematic biology, but has its own set of questions, approaches, and methods. Keywords and Concepts in Evolutionary Developmental Biology is the first comprehensive reference work for this expanding field. Covering more than fifty central terms and concepts in entries written by leading experts, Keywords offers an overview of all that is embraced by this new subdiscipline of biology, providing the core insights and ideas that show how embryonic development relates to life-history evolution, adaptation, and responses to and integration with environmental factors. (20031101)
	Centromere: Structure and Evolution (Progress in Molecular and Subcellular Biology) publisher: Springer, published: 2009-05-27 ASIN: 3642001815 EAN: 9783642001819 sales rank: 3139854 The centromere is a chromosomal locus that regulates the proper pairing and segregation of the chromosomes during cell division. Despite their conserved, essential function, centromeres are characterized by the rapid evolution of both centromeric DNA and proteins. This book presents current views on centromere structure and identity. It deals with the epigenetic concept of centromere establishment and maintenance as well as with the role of DNA and centromeric transcripts in centromere formation and function. Special emphasis is placed on centromere evolution: different evolutionary models are discussed in detail and the latest research on the evolution of new centromeres and neocentromeres is presented.
	Body by Science: A Research Based Program to Get the Results You Want in 12 Minutes a Week by: John Little publisher: McGraw-Hill, published: 2008-12-11 ASIN: 0071597174 EAN: 9780071597173 sales rank: 2072 Building muscle has never been faster or easier than with this revolutionary once-a-week training program In Body By Science, bodybuilding powerhouse John Little teams up with fitness medicine expert Dr. Doug McGuff to present a scientifically proven formula for maximizing muscle development in just 12 minutes a week. Backed by rigorous research, the authors prescribe a weekly high-intensity program for increasing strength, revving metabolism, and building muscle for a total fitness experience.
	The Scientific American Brave New Brain: How Neuroscience, Brain-Machine Interfaces, Neuroimaging, Psychopharmacology, Epigenetics, the Internet, and ... and Enhancing the Future of Mental Power by: Judith Horstman publisher: Jossey-Bass, published: 2010-04-05 ASIN: 0470376244 EAN: 9780470376249 sales rank: 182725 This fascinating and highly accessible book presents fantastic but totally feasible projections of what your brain may be capable of in the near future. It shows how scientific breakthroughs and amazing research are turning science fiction into science fact. In this brave new book, you'll explore: How partnerships between biological sciences and technology are helping the deaf hear, the blind see, and the paralyzed communicate. How our brains can repair and improve themselves, erase traumatic memories How we can stay mentally alert longer—and how we may be able to halt or even reverse Alzheimers How we can control technology with brain waves, including prosthetic devices, machinery, computers—and even spaceships or clones. Insights into how science may cure fatal diseases, and improve our intellectual and physical productivity Judith Horstman presents a highly informative and entertaining look at the future of your brain, based on articles from Scientific American and Scientific American Mind magazines, and the work of today’s visionary neuroscientists.
	Environmental Epigenomics in Health and Disease (Epigenetics and Human Health) publisher: Springer, published: 2012-07-28 ASIN: 3642233791 EAN: 9783642233791 There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.
	Chromatin and Disease (Subcellular Biochemistry) publisher: Springer, published: 2007-04-04 ASIN: 1402054653 EAN: 9781402054655 sales rank: 2470076 This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.
	DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment) publisher: Springer, published: 2011-01-11 ASIN: 9048169178 EAN: 9789048169177 sales rank: 3317414 This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.
	Neural Control of Development: The Epigenetic Theory of Heredity by: Nelson R. Cabej publisher: Albanet, published: 2005-12-06 ASIN: 0971074607 EAN: 9780971074606 sales rank: 2451401 The book presents a novel theory on the epigenetic system of heredity supported by extensive experimental and observational evidence. A control system, with the central nervous system as its controller, is responsible for maintaining the inexorably eroding structure of metazoans, including us humans. During individual development, that same system performs functions of an epigenetic system of heredity, providing trillions of bits of information necessary for erecting metazoan structure. The main topics discussed in the book are: - Hereditary systems as control systems - The integrated control system and the control of gene expression - Manipulative expression of genes in the central nervous system - The epigenetic control of reproduction - The epigenetic system of heredity - The epigenetics of evolutionary change
	The Mysterious Epigenome: What Lies Beyond DNA by: Thomas Woodward publisher: Kregel Publications, published: 2011-12-01 ASIN: 0825441927 EAN: 9780825441929 sales rank: 32048 In this creative and inventive treatment, authors Thomas E. Woodward and James P. Gills take readers on an exploration of the human epigenome. Acting as tour guides leading visitors through a 3-D model of a human cell, Woodward and Gills bring to life the human molecular makeup. Readers (as visitors) will get up close and personal with the minute details of human molecular structure, including E. coli, flagellum, a DNA helix, an RNA molecule, and more. By seeing it with their own eyes, readers will gain a better understanding of their genetic systems and a better appreciation for the Creator who put this all into place.
	Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life (Life and Mind: Philosophical Issues in Biology and Psychology) by: Eva Jablonka publisher: The MIT Press, published: 2005-05-01 ASIN: 0262101076 EAN: 9780262101073 sales rank: 1292648 Ideas about heredity and evolution are undergoing a revolutionary change. New findings in molecular biology challenge the gene-centered version of Darwinian theory according to which adaptation occurs only through natural selection of chance DNA variations. In Evolution in Four Dimensions, Eva Jablonka and Marion Lamb argue that there is more to heredity than genes. They trace four "dimensions" in evolution—four inheritance systems that play a role in evolution: genetic, epigenetic (or non-DNA cellular transmission of traits), behavioral, and symbolic (transmission through language and other forms of symbolic communication). These systems, they argue, can all provide variations on which natural selection can act. Evolution in Four Dimensions offers a richer, more complex view of evolution than the gene-based, one-dimensional view held by many today. The new synthesis advanced by Jablonka and Lamb makes clear that induced and acquired changes also play a role in evolution. After discussing each of the four inheritance systems in detail, Jablonka and Lamb "put Humpty Dumpty together again" by showing how all of these systems interact. They consider how each may have originated and guided evolutionary history and they discuss the social and philosophical implications of the four-dimensional view of evolution. Each chapter ends with a dialogue in which the authors engage the contrarieties of the fictional (and skeptical) "I.M.," or Ifcha Mistabra—Aramaic for "the opposite conjecture"—refining their arguments against I.M.'s vigorous counterarguments. The lucid and accessible text is accompanied by artist-physician Anna Zeligowski's lively drawings, which humorously and effectively illustrate the authors' points.