Related books on 'signal-transduction'
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publisher: Humana Press, published: 1997-10-10 ASIN: 0896034739 EAN: 9780896034730 sales rank: 4515437 Prominent researchers and clinicians dissect the signaling pathways of an array of neuroprotective factors, ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5) to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur with injured neurons independently of intercellular signals. In elucidating the molecular cascades evolved by the nervous system to protect itself, the contributors lay the basis for powerful new drug discovery and gene therapy strategies, and shed light on potential effective strategies for preventing neuron degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. |
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publisher: Humana Press, published: 2011-06-27 ASIN: 1617791253 EAN: 9781617791253 sales rank: 4547987 As our understanding of G protein-coupled receptor (GPCR) signal transduction continues to grow, we cannot help but be struck by the emerging complexity and the ability of this receptor superfamily to continually surprise us as new facets are discovered. In this third edition of Receptor Signal Transduction Protocols, the expert contributors have taken into account the constant evolution of the GPCR field and dealt with methods that allow researchers to address many of the important rising issues. Serving as a companion to the previous editions, this volume contains thorough revisions of some core chapters, the complete rewriting of others to encompass new technological developments since the publication of the prior editions, and the commissioning of brand new, cutting-edge chapters to expand on previous coverage. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to the respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Receptor Signal Transduction Protocols, Third Edition serves the scientific community with a broad collection of the current, practical methodologies in this highly promising field. |
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publisher: Springer, published: 2000-11-13 ASIN: 4431702105 EAN: 9784431702108 sales rank: 4685770 The past decade has seen remarkable advances in understanding the workings of the brain, and an essential part of that progress has resulted from important discoveries about signal transduction. Research in neuroscience has led to new insights into the relation between affective disorders and neural signaling. That research has not been widely integrated with clinical psychiatry, however, and until now a comprehensive presentation of research findings has not been published. This monograph brings together in one volume a review of the work of Japanese scientists in the fields of basic and clinical neuroscience. The papers compiled here are from the Symposium on Affective Disorders and Neuronal Signal Transduction and from the 11th Sapporo Neuroscience Meeting, both held in Sapporo, Japan, in 1996. The result is a comprehensive view of signal transduction in the brain and the pathophysiology of affective disorders as well as a review of the mechanisms of antidepressants. |
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by: Yehuda Gutman publisher: CRC Press, published: 1997-05-01 ASIN: 9057020785 EAN: 9789057020780 sales rank: 3913931 Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage. This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field. The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications. |
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publisher: Springer, published: 2010-11-24 ASIN: 1441927034 EAN: 9781441927033 This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, Bacterial Signal Transduction: Networks and Drug Targets. The aim of this book is to provide an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs. |
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by: Charles G. Cochrane publisher: Academic Pr, published: 1992-06 ASIN: 0121504034 EAN: 9780121504038 sales rank: 10112397 Intended for all researchers concerned with the immunological responses of inflammatory cells, this volume focuses on stimulus-induced signal-transduction in cells. These collected essays report on the current status of the essential elements of early events in signal transduction. |
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by: Masayori Inouye publisher: Academic Press, published: 2002-11-26 ASIN: 0123724848 EAN: 9780123724847 sales rank: 4729442 Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions. Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes. An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool. Key Features * The first comprehensive book on the roles of histidine kinases in cells * 23 in-depth chapters written by leading experts in the field * Describes the most recent advances in the field of signal transduction |
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publisher: Springer, published: 1993-12-31 ASIN: 0306445832 EAN: 9780306445835 sales rank: 6269396 |
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publisher: Springer, published: 2006-05-24 ASIN: 0387313354 EAN: 9780387313351 sales rank: 5587728 Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference. |
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publisher: Springer, published: 1995-02-28 ASIN: 0792333640 EAN: 9780792333647 sales rank: 10981368 Plants offer exciting opportunities to understand major biological questions, i.e. the regulation of development and morphogenesis. How are changes of the environment, developmental cues, and other signals perceived and transduced in physiological responses? What are the elements of plant signalling pathways and what is their organization? The panoply of molecular tools and techniques as well as the blossoming field of plant genetics are providing an exciting ground for major breakthroughs in unravelling the fundamental mechanisms of plant signalling. The present book establishes a state-of-the-art framework spanning the wide spectrum of perception, signal transduction events and transport processes, including cell proliferation and cell cycle regulation, embryogenesis, and flowering. Moreover, the volume emphasizes the role of the major plant signalling substances known to date (the phytohormones and more recently studied substances) and summarizes what we know on their molecular mechanisms of action. The book emphasizes how the use of molecular technology has made plant signalling processes accessible to experimental test. |