Related books on 'methods-in-molecular-biology'
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publisher: Humana Press, published: 2007-08-01 ASIN: 1588291006 EAN: 9781588291004 This book provides the essential protocols for disease gene identification as it describes and evaluates a range of techniques pertinent to the identification of diseases in man. |
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publisher: Humana Press, published: 2012-03-10 ASIN: 1603273360 EAN: 9781603273367 sales rank: 5673088 The modern state of the art in methodology of microarray data analysis based on significance testing is far from satisfactory. However "hot" this methodological research trend has been, it is still in its infancy and a real revolution in the field definitely lies ahead. In particular, the basic statistical problems will remain the same even after new digital technologies produced by Solexa and some other companies have become widely available. This volume "Statistical Methods for Microarray Data Analysis" will include selected papers on this subject that meet a high standard of mathematical rigor. |
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publisher: Springer, published: 2012-03-31 ASIN: 1617376507 EAN: 9781617376504 sales rank: 11135718 Over the past decades, the pathogenesis, diagnosis, treatment and prevention of cardiovascular diseases have been benefited significantly from intensive research activities. In order to provide a comprehensive “manual” in a field that has become as broad and deep as cardiovascular medicine, this volume of “Methods in Molecular Medicine” covers a wide spectrum of in vivo and in vitro techniques encompassing biochemical, pharmacological and molecular biology disciplines which are currently used to assess vascular disease progression. Each chapter included in this volume focuses on a specific vascular biology technique and describes various applications as well as caveats of these techniques. The protocols included here are described in detail, allowing beginners with little experience in the field of vascular biology to embark on new research projects. |
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publisher: Humana Press, published: 2012-02-29 ASIN: 1617795666 EAN: 9781617795664 Today, cells are commonly analyzed en masse, with thousands of cells per sample, yielding results on the average response of the cells. However, cellular heterogeneity implies that in order to learn more about cellular behaviour, it is important to study how individual cells respond, one by one. In Single-Cell Analysis: Methods and Protocols, experts in the field provide an update on the field of single-cell analysis wherein the latest findings and applications are described in detail. The methods described in this book include a few examples of conventional methods and several examples of miniaturized methods. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Single-Cell Analysis: Methods and Protocols encourages readers to explore new ways of studying cells that may help lead to exciting new discoveries. |
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publisher: Humana Press, published: 2012-02-29 ASIN: 1617795933 EAN: 9781617795930 sales rank: 5693161 Estimation of the metabolite complement of plant material involves a wide range of techniques and technologies and that breadth continues to increase. Metabolomics research typically involves multiple sites for material preparation and analysis and most investigations are “high throughput”, meaning that chemical analysis of sample sets are inevitably carried out over an extended period of time. In, Plant Metabolomics: Methods and Protocols expert researchers in the field detail many of the stages which are now commonly used to study plant metabolomics workflow. Stages of this workflow, up to and including the statistical analysis, accurate and detailed collection of meta-data are also essential for good process management, to satisfy reporting requirements and to ensure wider interpretability and reuse results.Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Through and intuitive Plant Metabolomics: Methods and Protocols, seeks to aid scientists in the further study of the methods for all the stages of the plant metabolomics workflow. |
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publisher: Springer, published: 2012-03-31 ASIN: 1617371505 EAN: 9781617371509 sales rank: 11135704 Colin Graham and a team of leading investigators and expert clinical scientists update the acclaimed first edition with a collection of powerful, up-to-date PCR-based methods for DNA sequencing, many suitable for human genome sequencing and mutation detection in human disease. This second edition offers new material on automated DNA sequencers, capillary DNA sequencers, heterozygote mutation detection, web-based sequencing databases and genome sequencing sites, and the human genome project. State-of-the-art and highly practical, DNA Sequencing Protocols, 2nd Edn. constitutes an essential laboratory handbook for geneticists and molecular biologists, offering concise, easy-to-follow methods that will work and impact today's genome sequencing projects. |
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publisher: Humana Press, published: 2010-11-19 ASIN: 1617376760 EAN: 9781617376764 Covering experiment and theory, bioinformatics approaches, and state-of-the-art simulation protocols for better sampling of the conformational space, this volume describes a broad range of techniques to study, predict, and analyze the protein folding process. Protein Folding Protocols also provides sample approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. |
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publisher: Humana Press, published: 2010-03-09 ASIN: 1607615789 EAN: 9781607615781 sales rank: 675168 While there is a wide selection of 'by experts, for experts’ books in statistics and molecular biology, there is a distinct need for a book that presents the basic principles of proper statistical analyses and progresses to more advanced statistical methods in response to rapidly developing technologies and methodologies in the field of molecular biology. Statistical Methods in Molecular Biology strives to fill that gap by covering basic and intermediate statistics that are useful for classical molecular biology settings and advanced statistical techniques that can be used to help solve problems commonly encountered in modern molecular biology studies, such as supervised and unsupervised learning, hidden Markov models, methods for manipulation and analysis of high-throughput microarray and proteomic data, and methods for the synthesis of the available evidences. This detailed volume offers molecular biologists a book in a progressive style where basic statistical methods are introduced and gradually elevated to an intermediate level, while providing statisticians knowledge of various biological data generated from the field of molecular biology, the types of questions of interest to molecular biologists, and the state-of-the-art statistical approaches to analyzing the data. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of meticulous descriptions and implementation advice for diverse topics that are crucial for getting optimal results. Comprehensive but convenient, Statistical Methods in Molecular Biology will aid students, scientists, and researchers along the pathway from beginning strategies to a deeper understanding of these vital systems of data analysis and interpretation within one concise volume. |
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publisher: Humana Press, published: 2010-12-09 ASIN: 1617374741 EAN: 9781617374746 sales rank: 691084 This collection of robust, readily reproducible methods for microarray-based studies includes expert guidance in the optimal data analysis and informatics. On the methods side are proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering. |
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by: Peter Sudbery publisher: Benjamin Cummings, published: 2010-02-21 ASIN: 0132051575 EAN: 9780132051576 sales rank: 1053013 A clear introduction to the complex and fast moving field of Human Molecular Genetics; recommended forstudents studying the subject as part of a general biology, genetics or medical degree. New to the third edition:
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