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Annual Plant Reviews, Plant Epigenetics (Volume 19)

publisher: Wiley-Blackwell, published: 2005-10-01
ASIN: 1405129778
EAN: 9781405129770
sales rank: 4800985
With the discovery of RNAi pathways and the histone code, epigenetics has become a popular and fast evolving research topic. Plant science has made a number of elementary contributions to this field, and the common elements of epigenetic systems have linked research groups interested in plant, fungal and animal systems.

This volume provides a comprehensive overview epigenetic mechanisms and biological processes in plants, illustrating the wider relevance of this research to work in other plant science areas and on non-plant systems. It discusses recent advances in our knowledge of basic mechanisms and molecular components that control transcriptional and post-transcriptional silencing, an understanding of which is essential for plant researchers who use transgenic lines for stable expression of a recombinant construct or for targeted inactivation of an endogenous gene. These aspects should be of special interest to the agricultural industry.

The volume illustrates the relevance of epigenetic control systems to gene regulation and plant development, examining paramutation, genomic imprinting and microRNA-based gene regulation mechanisms. Finally, it demonstrates the significance of epigenetic systems to viral defence and genome organisation.

The volume is directed at researchers and professionals in plant molecular genetics, plant biochemistry and plant developmental biology.

Mechanisms of Memory, Second Edition

by: J. David Sweatt
publisher: Academic Press, published: 2009-12-07
ASIN: 0123749514
EAN: 9780123749512
sales rank: 1274506
Many who work on the cellular and molecular processes of learning and memory are tempted to throw up their hands in frustration and conclude that the problem is insoluble. Human learning and memory is likely the most highly evolved and sophisticated biological process in existence. This book represents the first step at beginning to put together the complex puzzle of the molecular basis of memory. Sweatt creates a framework of thinking about synaptic plasticity and memory at the molecular level; one which recognizes and begins to incorporate this extreme biochemical complexity into our thinking about memory. Now in its second edition this is currently the only book on the market that takes this approach.

All chapters are fully revised, and four new chapters have been added. The book is adaptable for courses for senior level undergraduates and, first and second year graduate students. It will be of use to students interested in the medical professions and graduate students interested in translational aspects of basic memory research at a time when translational research is becoming a priority area for research funding agencies in the US and internationally.
More than 25% new content, particularly expanding the scope to include new findings in translational research.
Unique in its depth of coverage of molecular and cellular mechanisms
Extensive cross-referencing to Comprehensive Learning and Memory
Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples

Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma (Current Clinical Pathology)

publisher: Humana Press, published: 2011-12-01
ASIN: 1607614324
EAN: 9781607614326
sales rank: 1661141
This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

DNA Methylation: Methods and Protocols (Methods in Molecular Biology)

publisher: Humana Press, published: 2010-12-01
ASIN: 1617379387
EAN: 9781617379383
sales rank: 2957453
Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.

Nuclear Dynamics

publisher: Springer, published: 2007-01-12
ASIN: 4431300546
EAN: 9784431300540
sales rank: 5706718
The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Harrison's Principles of Internal Medicine: Volumes 1 and 2, 18th Edition

by: Dan Longo
publisher: McGraw-Hill Professional, published: 2011-07-21
ASIN: 007174889X
EAN: 9780071748896
sales rank: 1634

The most trusted textbook in medicine -- featuring the acclaimed Harrison's DVD with 57 additional chapters and exclusive video and tutorials

Now presented in TWO VOLUMES

Extensively revised and expanded by the world’s leading physicians, Harrison’s Principles of Internal Medicine, 18e continues to set the standard as the pinnacle of current medical knowledge and practice, offering the definitive review of disease mechanisms and management.

CURRENT
All chapters have been completely updated to reflect the latest knowledge and evidence, and important new chapters have been added, including: "Systems Biology in Health and Disease," "The Human Microbiome," "The Biology of Aging," and "Neuropsychiatric Illnesses in War Veterans."

CONNECTED
Harrison's covers more global aspects of medicine than any other textbook, and features such chapters as "Global Issues in Medicine," by Jim Yong Kim, Paul Farmer, and Joseph Rhatigan, and new to the 18th edition, "Primary Care in Low and Middle Income Countries."

COMPREHENSIVE
No other resource delivers coverage of disease mechanisms and management like Harrison's, including world-renowned chapters on HIV/AIDS, STEMI and non-STEMI myocardial infarction, cancer biology, multiple sclerosis, and diabetes.

The Harrison’s Multi-Media DVD— Better Than Ever!
The Harrison’s DVD has been expanded to include an extensive video demonstration of the neurological physical examination, and video tutorials on how to perform essential clinical procedures, including:

Thoracentesis
Abdominal Paracentesis
Endotracheal Intubation
Central Venous Catheter Placement

57 additional chapters and more than 2,000 images make the companion DVD an essential part of every physician's education, practice, and lifelong learning.The DVD also features PowerPoint presentations from fifty chapters to facilitate classroom lectures, and a free trial subscription to AccessMedicine.com (including Harrison's Online).

Harrison’s 18e is proud to present a tribute to longtime editor, Eugene Braunwald, MD for his outstanding and continuing contributions to medical knowledge and practice.

Pathophysiology, 4e

by: Lee-Ellen C. Copstead-Kirkhorn PhD RN
publisher: Saunders, published: 2009-02-02
ASIN: 1416055436
EAN: 9781416055433
sales rank: 10622
With dynamic full-color illustrations and an easy-to-read writing style, Pathophysiology, 4th Edition explores the etiology, pathogenesis, clinical manifestation, and treatment of disease. Each unit covers a specific body system and begins with an illustrated review of anatomy and normal physiology to prepare you for disease processes and abnormalities discussions. Coverage of the latest developments in pathophysiology and a wealth of student-friendly learning resources will help you understand all of the major degenerative, neoplastic, metabolic, immunologic and infectious diseases.
Highlighted Key Points focus you on the most important information.
Key Terms bolded within the text help you identify and understand new and important terms.
Key Questions for every chapter emphasize important concepts and develop critical thinking skills needed for practice.
Additional content on the Companion CD and the companion Evolve website provide more opportunities for learning with case study worksheets, additional exercises, animations, and much more.
Geriatric Considerations boxes discuss the age-related changes associated with each body system.
Frontiers in Research essays introduce each unit with an informative commentary on the history of scientific investigation, the current understanding, and potential future breakthroughs.
Revised content includes the most current information and research on RNA molecules in cell function, guidelines, heart failure, alzheimers, and more to keep you at the cutting-edge of pathophysiology.
A new focus on general introductory principles and data measurement in clinical practice provides a solid beginning to pathophysiology study.

Evolution: A View from the 21st Century (FT Press Science)

by: James A. Shapiro
publisher: FT Press, published: 2011-06-22
ASIN: 0132780933
EAN: 9780132780933
sales rank: 154390
James A. Shapiro's Evolution: A View from the 21st Century proposes an important new paradigm for understanding biological evolution. Shapiro demonstrates why traditional views of evolution are inadequate to explain the latest evidence, and presents a compelling alternative. His information- and systems-based approach integrates advances in symbiogenesis, epigenetics, and mobile genetic elements, and points toward an emerging synthesis of physical, information, and biological sciences.

Ovarian Cancer: State of the Art and Future Directions in Translational Research (Advances in Experimental Medicine and Biology)

publisher: Springer, published: 2010-11-19
ASIN: 1441923969
EAN: 9781441923967
sales rank: 4880046
Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. The Symposium on Ovarian Cancer: State of the Art and Future Directions intends to bring together international experts interested in the development of novel diagnostic, prognostic and therapeutic tools for ovarian cancer. The meeting will function as a think tank where clinicians, translational and basic scientists, and parties from the biotechnology and pharmaceutical industry will get together to review recent advances in clinical research and translational science in ovarian cancer and define areas of future research opportunities and priorities.

Fluorescence In Situ Hybridization (FISH) - Application Guide

publisher: Springer, published: 2010-11-19
ASIN: 3642089526
EAN: 9783642089527
sales rank: 668218
This FISH application guide provides an overview of the principles and the basic techniques of fluorescence in situ hybridization (FISH) and primed in situ hybridization (PRINS), which are successfully used to study many aspects of genomic behavior and alterations. In 36 chapters, contributed by international experts in their particular field, the nowadays multiple approaches and applications of the powerful techniques are presented and detailed protocols are given. Described here are methods using various cell types and tissues as well as different organisms, such as mammalians, insects, plants and microorganisms. Multicolor FISH procedures and special applications such as the characterization of marker chromosomes, breakpoints, cryptic aberrations, nuclear architecture and epigenetic changes, as well as (array-based) comparative genomic hybridization studies are presented. Overall, the technique of choice is introduced for single cell analysis in human genetics, microbiology, animal and plant sciences.

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	Annual Plant Reviews, Plant Epigenetics (Volume 19) publisher: Wiley-Blackwell, published: 2005-10-01 ASIN: 1405129778 EAN: 9781405129770 sales rank: 4800985 With the discovery of RNAi pathways and the histone code, epigenetics has become a popular and fast evolving research topic. Plant science has made a number of elementary contributions to this field, and the common elements of epigenetic systems have linked research groups interested in plant, fungal and animal systems. This volume provides a comprehensive overview epigenetic mechanisms and biological processes in plants, illustrating the wider relevance of this research to work in other plant science areas and on non-plant systems. It discusses recent advances in our knowledge of basic mechanisms and molecular components that control transcriptional and post-transcriptional silencing, an understanding of which is essential for plant researchers who use transgenic lines for stable expression of a recombinant construct or for targeted inactivation of an endogenous gene. These aspects should be of special interest to the agricultural industry. The volume illustrates the relevance of epigenetic control systems to gene regulation and plant development, examining paramutation, genomic imprinting and microRNA-based gene regulation mechanisms. Finally, it demonstrates the significance of epigenetic systems to viral defence and genome organisation. The volume is directed at researchers and professionals in plant molecular genetics, plant biochemistry and plant developmental biology.
	Mechanisms of Memory, Second Edition by: J. David Sweatt publisher: Academic Press, published: 2009-12-07 ASIN: 0123749514 EAN: 9780123749512 sales rank: 1274506 Many who work on the cellular and molecular processes of learning and memory are tempted to throw up their hands in frustration and conclude that the problem is insoluble. Human learning and memory is likely the most highly evolved and sophisticated biological process in existence. This book represents the first step at beginning to put together the complex puzzle of the molecular basis of memory. Sweatt creates a framework of thinking about synaptic plasticity and memory at the molecular level; one which recognizes and begins to incorporate this extreme biochemical complexity into our thinking about memory. Now in its second edition this is currently the only book on the market that takes this approach. All chapters are fully revised, and four new chapters have been added. The book is adaptable for courses for senior level undergraduates and, first and second year graduate students. It will be of use to students interested in the medical professions and graduate students interested in translational aspects of basic memory research at a time when translational research is becoming a priority area for research funding agencies in the US and internationally. More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
	Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma (Current Clinical Pathology) publisher: Humana Press, published: 2011-12-01 ASIN: 1607614324 EAN: 9781607614326 sales rank: 1661141 This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
	DNA Methylation: Methods and Protocols (Methods in Molecular Biology) publisher: Humana Press, published: 2010-12-01 ASIN: 1617379387 EAN: 9781617379383 sales rank: 2957453 Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace. Due to this fact, DNA Methylation: Methods and Protocols, Second Edition completely revises, updates, and expands upon the popular first edition with the most current novel techniques, easier to use and more refined by the tested experience of leading experts. This revision reflects contemporary study of the subject: the analysis of gene-specific DNA methylation patterns has been complemented by genome-wide approaches, and epigenomics takes a central place. Written in the highly successful Methods in Molecular Biology™ series format, the chapters in this volume present brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, DNA Methylation: Methods and Protocols, Second Edition is the perfect resource for scientists who wish to further our understanding of the molecular processes that determine the genomic DNA methylation landscape and for those who aim to identify and implement DNA methylation-based biomarkers for clinical and diagnostic applications.
	Nuclear Dynamics publisher: Springer, published: 2007-01-12 ASIN: 4431300546 EAN: 9784431300540 sales rank: 5706718 The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
	Harrison's Principles of Internal Medicine: Volumes 1 and 2, 18th Edition by: Dan Longo publisher: McGraw-Hill Professional, published: 2011-07-21 ASIN: 007174889X EAN: 9780071748896 sales rank: 1634 *The most trusted textbook in medicine -- featuring the acclaimed Harrison's* DVD with 57 additional chapters and exclusive video and tutorials Now presented in TWO VOLUMES** Extensively revised and expanded by the world’s leading physicians, Harrison’s Principles of Internal Medicine, 18e continues to set the standard as the pinnacle of current medical knowledge and practice, offering the definitive review of disease mechanisms and management. CURRENT All chapters have been completely updated to reflect the latest knowledge and evidence, and important new chapters have been added, including: "Systems Biology in Health and Disease," "The Human Microbiome," "The Biology of Aging," and "Neuropsychiatric Illnesses in War Veterans." CONNECTED Harrison's covers more global aspects of medicine than any other textbook, and features such chapters as "Global Issues in Medicine," by Jim Yong Kim, Paul Farmer, and Joseph Rhatigan, and new to the 18th edition, "Primary Care in Low and Middle Income Countries." COMPREHENSIVE No other resource delivers coverage of disease mechanisms and management like Harrison's, including world-renowned chapters on HIV/AIDS, STEMI and non-STEMI myocardial infarction, cancer biology, multiple sclerosis, and diabetes. *The Harrison’s* Multi-Media DVD— Better Than Ever!** The Harrison’s DVD has been expanded to include an extensive video demonstration of the neurological physical examination, and video tutorials on how to perform essential clinical procedures, including: Thoracentesis Abdominal Paracentesis Endotracheal Intubation Central Venous Catheter Placement 57 additional chapters and more than 2,000 images make the companion DVD an essential part of every physician's education, practice, and lifelong learning.The DVD also features PowerPoint presentations from fifty chapters to facilitate classroom lectures, and a free trial subscription to AccessMedicine.com (including Harrison's Online). Harrison’s 18e is proud to present a tribute to longtime editor, Eugene Braunwald, MD for his outstanding and continuing contributions to medical knowledge and practice.
	Pathophysiology, 4e by: Lee-Ellen C. Copstead-Kirkhorn PhD RN publisher: Saunders, published: 2009-02-02 ASIN: 1416055436 EAN: 9781416055433 sales rank: 10622 With dynamic full-color illustrations and an easy-to-read writing style, Pathophysiology, 4th Edition explores the etiology, pathogenesis, clinical manifestation, and treatment of disease. Each unit covers a specific body system and begins with an illustrated review of anatomy and normal physiology to prepare you for disease processes and abnormalities discussions. Coverage of the latest developments in pathophysiology and a wealth of student-friendly learning resources will help you understand all of the major degenerative, neoplastic, metabolic, immunologic and infectious diseases. Highlighted Key Points focus you on the most important information. Key Terms bolded within the text help you identify and understand new and important terms. Key Questions for every chapter emphasize important concepts and develop critical thinking skills needed for practice. Additional content on the Companion CD and the companion Evolve website provide more opportunities for learning with case study worksheets, additional exercises, animations, and much more. Geriatric Considerations boxes discuss the age-related changes associated with each body system. Frontiers in Research essays introduce each unit with an informative commentary on the history of scientific investigation, the current understanding, and potential future breakthroughs. Revised content includes the most current information and research on RNA molecules in cell function, guidelines, heart failure, alzheimers, and more to keep you at the cutting-edge of pathophysiology. A new focus on general introductory principles and data measurement in clinical practice provides a solid beginning to pathophysiology study.
	Evolution: A View from the 21st Century (FT Press Science) by: James A. Shapiro publisher: FT Press, published: 2011-06-22 ASIN: 0132780933 EAN: 9780132780933 sales rank: 154390 James A. Shapiro's Evolution: A View from the 21st Century proposes an important new paradigm for understanding biological evolution. Shapiro demonstrates why traditional views of evolution are inadequate to explain the latest evidence, and presents a compelling alternative. His information- and systems-based approach integrates advances in symbiogenesis, epigenetics, and mobile genetic elements, and points toward an emerging synthesis of physical, information, and biological sciences.
	Ovarian Cancer: State of the Art and Future Directions in Translational Research (Advances in Experimental Medicine and Biology) publisher: Springer, published: 2010-11-19 ASIN: 1441923969 EAN: 9781441923967 sales rank: 4880046 Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. The Symposium on Ovarian Cancer: State of the Art and Future Directions intends to bring together international experts interested in the development of novel diagnostic, prognostic and therapeutic tools for ovarian cancer. The meeting will function as a think tank where clinicians, translational and basic scientists, and parties from the biotechnology and pharmaceutical industry will get together to review recent advances in clinical research and translational science in ovarian cancer and define areas of future research opportunities and priorities.
	Fluorescence In Situ Hybridization (FISH) - Application Guide publisher: Springer, published: 2010-11-19 ASIN: 3642089526 EAN: 9783642089527 sales rank: 668218 This FISH application guide provides an overview of the principles and the basic techniques of fluorescence in situ hybridization (FISH) and primed in situ hybridization (PRINS), which are successfully used to study many aspects of genomic behavior and alterations. In 36 chapters, contributed by international experts in their particular field, the nowadays multiple approaches and applications of the powerful techniques are presented and detailed protocols are given. Described here are methods using various cell types and tissues as well as different organisms, such as mammalians, insects, plants and microorganisms. Multicolor FISH procedures and special applications such as the characterization of marker chromosomes, breakpoints, cryptic aberrations, nuclear architecture and epigenetic changes, as well as (array-based) comparative genomic hybridization studies are presented. Overall, the technique of choice is introduced for single cell analysis in human genetics, microbiology, animal and plant sciences.