Vector-based siRNA delivery strategies for high-throughput screening of novel target genes

An open access review article downloadable in pdf format on vector based siRNA delivery strategies published on Journal of RNAi and Gene Silencing.

Journal of RNAi and Gene Silencing (2005), 1(1), 5-11

Meihong Chen, Quan Du, Hong-Yan Zhang, Claes Wahlestedt and Zicai Liang

ABSTRACT

Application of siRNA in high-throughput fashion is still in its early phase although the principle has been established for three years. In this review, we outline the different vector-based siRNA delivery platforms as well as resources that are becoming available for high-throughput applications, and some initial outcomes of vector siRNA high-throughput screening efforts using vector encoded siRNA. It is expected that further im-provement of the siRNA technology and availability of the siRNA resources will help to materialize the po-tential of siRNA for functional genomics and drug target validation.

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