Gene dosage

Gene dosage determination are techniques to accurately detect the number of copies of a specified gene per somatic cell. Commonly used gene dosage detection techniques include PCR (real-time quantitative PCR) and southern blot analysis.

Mesh definition: The number of copies of a given gene present in a cell or nucleus. An increase in gene dosage can result in the formation of higher levels of gene product, provided that the gene is not subject to autogenous regulation.

References:

Precise gene dosage determination by polymerase chain reaction: theory, methodology, and statistical approach (Lubin et.al). Mol Cell Probes. 1991 Aug;5(4):307-17.

Determining Gene Dosage (Prior TW). Clinical Chemistry. 1998;44:703-704

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