Chromatography data system (CDS)

Chromatography data system (CDS)

Acquisition of chromatography data system CDS

Integration of chromatography data system CDS

Identification of chromatography data system CDS

Calibration and Quantitation of chromatography data system CDS

Validation of chromatography data system CDS

Chromatography Data System (CDS) Introduction

Chromatography data system (CDS) is data management system for chromatography in a wide range of situations including stand-alone four-channel chromatography system (workstation) to client-server multi-user, multi-channel environment (client-server distributed system). Chromatography data system generally contains several modules to control instruments, manage user privileges, manage reports and license etc. CDS provides automated solution for chromatography data acquisition, data processing and reporting. Chromatography data are stored in centralized database and can be configured to interact with Laboratory Information Management System (LIMS). CDS from different vendors can support different instrument control types, commonly supported devices including thermostated autosamplers, binary pump, isocratic pump, quaternary pump, degasser, refractive index detector, column heater, variable wavelength detector, diode array detector, fluorescence detector etc.

Chromatography data acquisition

CDS user interface can define the sample acquisition sequence, multiple injection for a given sample, run time, and sampling rate. The sampling run on a connected chromatography device is initiated based on the data acquisition parameters from CDS and the run information including chromatogram is then uploaded to CDS from the device.

Integration of chromatography data

Chromatography data integration can be conducted on CDS to detect chromatogram peaks, measure retention times, areas and height.

Identification of components

Chromatography component identification is the critical step to identify and label chromatogram peaks corresponding to known components using retention time window.

Calibration and quantification of components

Identified components are quantified using the calibration curve generated from internal or external standard.

Validation of chromatography data system CDS

Chromatography data system in R&D and manufacturing environment need to be validated in order to meet internal QA requirements and be compliance with FDA, EU regulations.

Last update 05-Mar-2010, Rating of 0 votes.

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