A First Course in Pharmacokinetics and Biopharmaceutics

An online tutorial written by David Bourne, Ph.D. Contents are also available in CD.

Content
1. Introduction to Course
* Staff
* Grading
* Coursework
* Laboratory Experiments
* Textbook
* Other References
* Journals
* 2. Background Material
* Exponents
* Logarithms
* Semi-log graph paper
* Calculus
* Differential Calculus
* Integral Calculus
* Spreadsheet Calculations
* Spectrophotometric Analysis
* 3. Pharmacokinetic Introduction
* 4. One Compartment I.V. Bolus
* Assumptions
* First-order kinetics
* Plasma data
* Area under the Curve
* Half-life
* 5. Analysis of Urine Data
* Excretion Unchanged - No Metabolism
* Metabolism and Excretion - Parallel Pathways
* Clearance, CL
* 6. Intravenous Infusion
* Continuous infusion - steady state
* Combined Infusion and bolus administration
* Combined slow and fast infusion
* Post infusion
* 7. Routes of Drug Administration
* Oral
* Buccal/Sublingual
* Rectal
* Intravenous
* Subcutaneous
* Intramuscular
* Inhalation
* Topical
* Other ROA's
* 8. Pharmacokinetics of Oral Administration
* Differential equation
* Integrated equation
* Absorption rate constant, ka
* Extent of absorption
* 9. Calculation of Bioavailability Parameters
* Calculation of ka
* Calculation of F
* 10. Bioavailability Studies
* Definitions
* Past bioavailability problems
* Reasons for bioequivalence requirements
* Bioavailability study characteristics
* 11. Physiological Factors Affecting Oral Absorption
* Membrane physiology
* Gastrointestinal physiology
* 12. Physical-Chemical Factors Affecting Oral Absorption
* pH - partition
* Drug dissolution
* 13. Formulation Factors
* Solutions
* Suspensions
* Capsules
* Tablets
* Sustained release tablets
* In vitro dosage form testing
* 14. Multiple IV Bolus Dose Administration
* Single dose summary
* IV bolus
* IV infusion
* Oral administration
* Multiple IV bolus
* Independent doses
* Accumulating doses
* Development of general equation
* Cpmax and Cpmin equations

* 15. Multiple Oral Dose Administration
* Cpmin equation
* Average Cp equation
* Non-uniform dosing intervals
* 16. Routes of Excretion
* Renal excretion
* Hemodialysis
* Biliary excretion
* Pulmonary excretion
* Salivary excretion
* Renal disease considerations
* Dose adjustment
* Average Cp calculations
* Cpmax/Cpmin calculations

* 17. Metabolism
* Metabolic reactions
* Phase I
* Phase II
* Induction
* Inhibition
* Hepatic clearance
* Systemic availability
* 18. Drug Distribution
* Drug distribution patterns
* Factors affecting drug distribution
* Rate of distribution
* Extent of distribution
* Weight considerations
* Protein binding interactions
* 19. Multi-Compartment Pharmacokinetic Models
* Intravenous administration
* Scheme or diagram
* Differential equation
* Integrated equation
* Parameter determination
* Effect of k12 and k21
* Apparent volumes of distribution
* Dosage calculations
* Oral administration
* Non Compartmental Analysis
* 20. Non-Linear Pharmacokinetic Models
* Scheme or diagram
* Differential equation
* Parallel pathway
* Dosing approaches
* 21. Clinical Applications of Pharmacokinetics
* Therapeutic drug monitoring
* Pediatric considerations
* Geriatric considerations
* 22. Laboratory Assignments
* Introduction
* Analysis of drugs by visible spectroscopy
* Extraction of salicylic acid
* One compartment model - IV bolus
* One compartment model - IV infusion
* One compartment model - Oral
* Computer simulation - single dose
* Student presentation concerning Biopharmaceutics
* One compartment model-IV bolus- multiple dose
* Computer simulation - multiple dose
* Computer simulation - two compartment models
* Student presentations on Pharmacokinetics
* Pharmacokinetic simulations using MacDope

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Last update 12-Apr-2005, Rating Good of 13 votes.