A First Course in Pharmacokinetics and Biopharmaceutics

An online tutorial written by David Bourne, Ph.D. Contents are also available in CD.

Content
1. Introduction to Course
* Staff
* Grading
* Coursework
* Laboratory Experiments
* Textbook
* Other References
* Journals
* 2. Background Material
* Exponents
* Logarithms
* Semi-log graph paper
* Calculus
* Differential Calculus
* Integral Calculus
* Spreadsheet Calculations
* Spectrophotometric Analysis
* 3. Pharmacokinetic Introduction
* 4. One Compartment I.V. Bolus
* Assumptions
* First-order kinetics
* Plasma data
* Area under the Curve
* Half-life
* 5. Analysis of Urine Data
* Excretion Unchanged - No Metabolism
* Metabolism and Excretion - Parallel Pathways
* Clearance, CL
* 6. Intravenous Infusion
* Continuous infusion - steady state
* Combined Infusion and bolus administration
* Combined slow and fast infusion
* Post infusion
* 7. Routes of Drug Administration
* Oral
* Buccal/Sublingual
* Rectal
* Intravenous
* Subcutaneous
* Intramuscular
* Inhalation
* Topical
* Other ROA's
* 8. Pharmacokinetics of Oral Administration
* Differential equation
* Integrated equation
* Absorption rate constant, ka
* Extent of absorption
* 9. Calculation of Bioavailability Parameters
* Calculation of ka
* Calculation of F
* 10. Bioavailability Studies
* Definitions
* Past bioavailability problems
* Reasons for bioequivalence requirements
* Bioavailability study characteristics
* 11. Physiological Factors Affecting Oral Absorption
* Membrane physiology
* Gastrointestinal physiology
* 12. Physical-Chemical Factors Affecting Oral Absorption
* pH - partition
* Drug dissolution
* 13. Formulation Factors
* Solutions
* Suspensions
* Capsules
* Tablets
* Sustained release tablets
* In vitro dosage form testing
* 14. Multiple IV Bolus Dose Administration
* Single dose summary
* IV bolus
* IV infusion
* Oral administration
* Multiple IV bolus
* Independent doses
* Accumulating doses
* Development of general equation
* Cpmax and Cpmin equations

* 15. Multiple Oral Dose Administration
* Cpmin equation
* Average Cp equation
* Non-uniform dosing intervals
* 16. Routes of Excretion
* Renal excretion
* Hemodialysis
* Biliary excretion
* Pulmonary excretion
* Salivary excretion
* Renal disease considerations
* Dose adjustment
* Average Cp calculations
* Cpmax/Cpmin calculations

* 17. Metabolism
* Metabolic reactions
* Phase I
* Phase II
* Induction
* Inhibition
* Hepatic clearance
* Systemic availability
* 18. Drug Distribution
* Drug distribution patterns
* Factors affecting drug distribution
* Rate of distribution
* Extent of distribution
* Weight considerations
* Protein binding interactions
* 19. Multi-Compartment Pharmacokinetic Models
* Intravenous administration
* Scheme or diagram
* Differential equation
* Integrated equation
* Parameter determination
* Effect of k12 and k21
* Apparent volumes of distribution
* Dosage calculations
* Oral administration
* Non Compartmental Analysis
* 20. Non-Linear Pharmacokinetic Models
* Scheme or diagram
* Differential equation
* Parallel pathway
* Dosing approaches
* 21. Clinical Applications of Pharmacokinetics
* Therapeutic drug monitoring
* Pediatric considerations
* Geriatric considerations
* 22. Laboratory Assignments
* Introduction
* Analysis of drugs by visible spectroscopy
* Extraction of salicylic acid
* One compartment model - IV bolus
* One compartment model - IV infusion
* One compartment model - Oral
* Computer simulation - single dose
* Student presentation concerning Biopharmaceutics
* One compartment model-IV bolus- multiple dose
* Computer simulation - multiple dose
* Computer simulation - two compartment models
* Student presentations on Pharmacokinetics
* Pharmacokinetic simulations using MacDope

Last update 12-Apr-2005, Rating of 16 votes.

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	By ALSON Sylvain Giovani on 22-Dec-2008 je viens d'obtenir mon DEA en pharmacologie, option pharmacocinetique et je souhaite poursuivre mes études en Doctorat dans ce domaine. pourrai-je trouver un laboratoire d'accueil pour cela? et qu'est ce que je dois faire pour cela? Merçi de votre compréhension. Rating: Reply

	By patel on 18-Sep-2008 i want to know the equation for calulating the dose for the sustained release tablet. Rating: Reply

	By Detroja chetan on 06-Sep-2008 Respected Sir, i would like to know about Factorial design Rating: Reply

	By khalid shaukat on 22-Aug-2008 respected sir,i being confused after studying compartment model of pharmacokinetics,will u explain multiple compartment model for me,plz Rating: Reply

	By Naren on 15-Aug-2008 sir, I want detailed information about of non-compartment modeling and its application in clinical pharmacokinetics and research. Rating: Reply

	By rajatkumarkar on 01-Apr-2008 Sir, I want to know about multiple regression in fectorial design Rating: Reply

	By shanker on 16-Jan-2008 respected sir, i want dose calculation for buccal drug delivery Rating: Reply

	By praveen kumar.y on 21-Aug-2007 ok nice,good but iam not getting full matter about one compartment model technique iv bolus and iv infusion Rating: Reply

	By Anan Udombhornprabha on 02-Aug-2007 The outline tutorials are very systematic and I find it very useful. Rating: Reply

	By akabir mohieldin on 20-May-2007 dr David Bourne i'm a pharmacy semifinal student in Ribat Universityin Sudan,i would like you to sugest some subjects for my final year research. Rating: Reply

	By Aminul Islam on 02-May-2007 sir, i m doing my PhD in Pharmacokinetics of some formulation ,doing enzyme assay,in Jadavpur University,Kolkata.India. sir, can you send me some articles about this Topic. Anticipating in a favourable reply. thanking you. Rating: Reply

	By Veena Somasundaram on 04-Jul-2006 I am a student of MSc Biotechnology in Tamil Nadu, India. I want to extract salicylic acid from turmeric. Is there a protocol available for that? Hoping for a positive correspondence. veena Rating: Reply

	By ashish verma on 01-Mar-2006 sir, i m doing my M.pharm second year project work in Oral mucosal Drug delivery system from Mahatma Gandhi University,College Of Pharmaceutical sciences,cheruvandoor campus,Kottayam,India. sir, can you send me some articles about this Topic. Anticipating in a favourable reply. thanking you. Rating: Reply

	By Abhishek Chanchal on 03-Aug-2005 It is the ultimate outline tutorial, really very good Rating: Reply

	By Hira on 16-Jun-2005 what should be the order of reaction for intra venous bolus injection Rating: Reply

	By Uday Harle on 12-Apr-2005 It is a potential contents of pharmacokinetics at all level. Rating: Reply

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