BITOLA - Biomedical Discovery Support System

BITOLA is an interactive literature-based biomedical discovery support system (available in either cgi-bin version or java applet version). The purpose of the system is to help the biomedical researchers make new discoveries by discovering potentially new relations between biomedical concepts. The set of concepts currently contains MeSH (Medical Subject Heading), which is used to index Medline, and around 22000 human genes from HUGO and LocusLink. The potentially new relations are discovered by mining the Medline database (currently around 11000000 citations from 1966 to end of 2001).


Reference:

Using literature-based discovery to identify disease candidate genes.

Hristovski D, Peterlin B, Mitchell JA, Humphrey SM.

Institute of Biomedical Informatics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2/2 1104 Ljubljana, Slovenia; Lister Hill National Center for Biomedical Communications, National Library of Medicine, Bethesda, USA.

We present BITOLA, an interactive literature-based biomedical discovery support system. The goal of this system is to discover new, potentially meaningful relations between a given starting concept of interest and other concepts, by mining the bibliographic database MEDLINE((R)). To make the system more suitable for disease candidate gene discovery and to decrease the number of candidate relations, we integrate background knowledge about the chromosomal location of the starting disease as well as the chromosomal location of the candidate genes from resources such as LocusLink and Human Genome Organization (HUGO). BITOLA can also be used as an alternative way of searching the MEDLINE database. The system is available at http://www.mf.uni-lj.si/bitola/.

PMID: 15694635 [PubMed - in process]

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Last update 27-Feb-2005, Rating n/a of 0 votes.