Information hyperlinked over proteins (archive)
A publicly accessible server for protein-protein interaction annotation. The full text reference can be downloaded from iHOP site.
Reference:
A gene network for navigating the literature
A network of genes and proteins extends through the scientific literature, touching on phenotypes, pathologies and gene function. We report the development of an information system that provides this network as a natural way of accessing the more than ten million abstracts in PubMed. By using genes and proteins as hyperlinks between sentences and abstracts, we convert the information in PubMed into one navigable resource and bring all the advantages of the internet to scientific literature investigation.
Moreover, this literature network can be superimposed on experimental interaction data (e.g. yeast two-hybrid data from Drosophila melanogaster and Caenorhabditis elegans) to make possible a simultaneous analysis of new and existing knowledge. The network, called Information Hyperlinked over Proteins (iHOP), contains half a million sentences and 30,000 different genes from humans, mice, D. melanogaster, C. elegans, zebrafish, Arabidopsis thaliana, yeast and Escherichia coli.
The iHOP server is publicly accessible at http://www.pdg.cnb.uam.es/UniPub/iHOP/.
Hoffmann, R., Valencia, A. A gene network for navigating the literature. Nature Genetics 36, 664 (2004).
Update from the author:
1. Entrez Gene linking to iHOP (Information Hyperlinked over Proteins)
With October 2005 the U.S. National Institute of Health started to include the iHOP-resource officially in its LinkOut program. Users of the prominent Entrez web portal (http://www.ncbi.nlm.nih.gov/) can now get directly from Entrez-Gene records to corresponding entries in iHOP. See for example: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=ExternalLink&list_uids=852088
2. Address Change
The official address of iHOP (Information Hyperlinked over Proteins) has changed. Its new address is http://www.ihop-net.org/UniPub/iHOP/
(The old address will be discontinued.)
Last update 18-Apr-2005, Rating n/a of 0 votes.
